진도견에서 발생한 원발성 결막 비만세포종양 1예

Primary Conjunctival Mast Cell Tumor in a Korean Native Jindo Dog

  • 이재연 (충남대학교 수의과대학.동물의과학연구소) ;
  • 정성목 (충남대학교 수의과대학.동물의과학연구소)
  • Lee, Jae Yeon (College of Veterinary Medicine.Research Institute of Veterinary Medicine, Chungnam National University) ;
  • Jeong, Seong Mok (College of Veterinary Medicine.Research Institute of Veterinary Medicine, Chungnam National University)
  • 심사 : 2013.03.26
  • 발행 : 2013.04.30

초록

9 년령 23 kg의 암컷 진도견이 2개월 동안의 안구 분비물을 주요증상으로 본원에 내원하였다. 초기 안검사에서 좌측 아래 안구 결막 부위에서 크기 2 cm의 길게 돌출 된 종괴를 발견하였다. 다른 안구 및 주위 조직의 이상소견을 확인하기 위해 안구초음파를 실시 하였고 모두 음성으로 판명되었다. 또한 흉 복부에 실시한 X-ray 검사에서도 특이 소견이 관찰되지 않았다. 세포학적 검사에서 다수의 원형세포와 중등도의 호산구 (eosinophils)가 관찰되었다. 종괴는 외과적으로 절제되었고 조직학적 검사를 통해 비만세포종 (mast cell tumor)로 진단되었다. 수술 후 6개월 뒤 실시한 흉복부 X-ray 및 초음파 검사에서 종양의 전이 또는 재발은 관찰되지 않았다.

A 9-year-old, intact female Jindo dog weighing 23 kg was presented to the Veterinary Medical Teaching Hospital of Chungnam National University with a history of two months of ocular discharge. Initial ocular examination showed a 2 cm elongated mass arising from the ventral bulbar conjunctiva of the left eye. Ocular ultrasound, performed to rule out any orbital and intraocular involvement, was negative. Thoracic radiographs and abdominal ultrasonography revealed no abnormalities. Fine needle aspiration (FNA) of mass was performed. Aspiration cytology showed the presence of a round cell population mostly characterized. A moderate amount of eosinophils was present among round cells. The mass was excised and identified hitologically as a mast cell tumor. Six months after surgical treatment, thoracic radiographs and abdominal ultrasonography did not reveal any clinical signs of local recurrence or metastatic disease.

키워드

참고문헌

  1. Bonney CH, Koch SA, Dice PF. Papillomatosis of the conjunctiva and adnexa in dogs. J Am Vet Med Assoc 1980; 176: 48-51.
  2. Boscos CM, Ververidis HN, Tondis DK. Ocular involvement of transmissible venereal tumor in a dog. Vet Ophthalmol 1998; 1: 167-170. https://doi.org/10.1046/j.1463-5224.1998.00012.x
  3. Bostock DE. The prognosis following surgical removal of mastocytomas in dogs. J Small Anim Pract 1973; 14: 27-40. https://doi.org/10.1111/j.1748-5827.1973.tb06891.x
  4. Calvert CA. Canine viral and transmissible neoplasm. In: Greene CE, ed. Clinical microbiology and infectious diseases of the dog and cat. Philadelphia: WB Saunders. 1984: 469-475.
  5. Collins BK, Collier LL, Miller MA. Biological behavior and histologic characteristics of canine conjunctival melanoma. Prog Vet Compar Ophthalmol 1993; 3: 135-140.
  6. Donaldson D, Day MJ. Epitheliotropic lymphoma (mycoses fungoides) presenting as blepharoconjunctivitis in an Irish setter. J Small Animal Practice 2000; 41: 317-320. https://doi.org/10.1111/j.1748-5827.2000.tb03209.x
  7. Fife M, Blocker T, Fife T, Dubielzig RR, Dunn K. Canine conjunctival mast cell tumors: a retrospective study. Vet Ophthalmol 2011; 14: 153-160. https://doi.org/10.1111/j.1463-5224.2010.00857.x
  8. George C, Summers BA. Angiokeratoma: a benign vascular tumor of the dog. J Small Animal Practice 1990; 31: 390-392. https://doi.org/10.1111/j.1748-5827.1990.tb00489.x
  9. Giovanni Barsotti, Veronica Marchetti, Francesca Abramo. Primary conjunctival mast cell tumor in a Labrador Retriever. Vet Ophthalmol 2007; 10: 60-64. https://doi.org/10.1111/j.1463-5224.2007.00502.x
  10. Hallstrom M. Mastocytoma in the third eyelid of a dog. J Small Anim Pract 1970; 11: 469-472. https://doi.org/10.1111/j.1748-5827.1970.tb05597.x
  11. Hargis AM, Lee AC, Thomassen RW. Tumor and tumorlike lesions of perilimbal conjunctiva in laboratory dogs. J Am Vet Med Assoc 1978; 173: 1185-1190.
  12. Hendrix DVH. Diseases and surgery of the canine conjunctiva. In: Veterinary ophthalmology, 3rd ed. Philadelphia: Williams & Wilkins. 1999: 619-634.
  13. Johnson BW, Brightman AH, Whiteley HE. Conjunctival mast cell tumor in two dogs. J Am Anim Hosp Assoc 1988; 24: 439-442.
  14. Mughannam AJ, Hacker DV, Spangler WL. Conjunctival vascular tumors in six dogs. Vet Compar Ophthalmol 1997; 7: 56-59.
  15. Multari D, Vascellari M, Mutinelli F. Hemangiosarcoma of the third eyelid in a cat. Vet Ophthalmol 2002; 5: 273-276. https://doi.org/10.1046/j.1463-5224.2002.00254.x
  16. Scherlie PH, Smedes SL, Feltz T. Ocular manifestations of histiocytosis in a dog. J Am Vet Med Assoc 1992; 201: 1229-1232.
  17. Tams TR, Macy DW. Canine mast cell tumors. Compend Contin Educ Pract Vet 1981; 3: 869-877.
  18. Vascellari M, Multari D, Mutinelli F. Unicentric extranodal lymphoma of the upper eyelid conjunctiva in a dog. Vet Ophthalmol 2005; 8: 67-70. https://doi.org/10.1111/j.1463-5224.2005.04053.x