Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of Ergosterol and 5,6-Dihydroergosterol Glycosides and Their Inhibitory Activities on Lipopolysaccharide-Induced Nitric Oxide Production

  • Park, HoonGyu (Department of Applied Chemistry, College of Applied Sciences, Kyung Hee University) ;
  • Lee, Tae Hoon (Graduate School of Biotechnology and College of Life Sciences, Skin Biotechnology Center, Kyung Hee University) ;
  • Chang, Fei (Department of Applied Chemistry, College of Applied Sciences, Kyung Hee University) ;
  • Kwon, Hyun Ji (Department of Applied Chemistry, College of Applied Sciences, Kyung Hee University) ;
  • Kim, Jiyoung (Graduate School of Biotechnology and College of Life Sciences, Skin Biotechnology Center, Kyung Hee University) ;
  • Kim, Hakwon (Department of Applied Chemistry, College of Applied Sciences, Kyung Hee University)
  • Received : 2012.12.06
  • Accepted : 2013.02.02
  • Published : 2013.05.20
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Abstract

We have synthesized several glycosyl ergosterols and 5,6-dihydroergosterols (DHE) and examined their effects on production of nitric oxide (NO) and iNOS protein expression in LPS-treated RAW264.7 macrophage cells. Our results showed that DHE derivatives inhibited production of NO and iNOS protein expression more strongly than ergosterol derivative. Especially, DHE-Glc exhibited most potent inhibitory activity without cytotoxicity up to the concentration of $100{\mu}M$.

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References

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