DOI QR코드

DOI QR Code

Effect of Orally Administered Lactobacillus brevis HY7401 in a Food Allergy Mouse Model

  • Lee, Jeongmin (Laboratory of Immunology, College of Veterinary Medicine, Seoul National University) ;
  • Bang, Jieun (Laboratory of Immunology, College of Veterinary Medicine, Seoul National University) ;
  • Woo, Hee-Jong (Laboratory of Immunology, College of Veterinary Medicine, Seoul National University)
  • Received : 2013.06.19
  • Accepted : 2013.08.27
  • Published : 2013.11.28

Abstract

We had found that orally administered Lactobacillus species were effective immune modulators in ovalbumin (OVA)-sensitized mice. To validate these findings, we investigated the effects of orally administered Lactobacillus brevis HY7401 in OVA-T cell receptor transgenic mice. This strain showed a tendency to induce Th1 cytokines and inhibit Th2 cytokines. All assayed isotypes of OVA-specific antibody were effectively reduced. Systemic anaphylaxis was also relatively reduced with the probiotic administration. These results reveal that L. brevis HY7401 might be useful to promote anti-allergic processes through oral administration.

Keywords

References

  1. Borchers AT, Selmi C, Meyers FJ, Keen CL, Gershwin ME. 2009. Probiotics and immunity. J. Gastroenterol. 44: 26-46. https://doi.org/10.1007/s00535-008-2296-0
  2. Frossard CP, Eigenmann PA. 2008. The role of IL-10 in preventing food-induced anaphylaxis. Expert Opin. Biol. Ther. 8: 1309-1317. https://doi.org/10.1517/14712598.8.9.1309
  3. Gajewski TF, Goldwasser E, Fitch FW. 1988. Anti-proliferative effect of IFN-gamma in immune regulation. II. IFN-gamma inhibits the proliferation of murine bone marrow cells stimulated with IL-3, IL-4, or granulocyte-macrophage colonystimulating factor. J. Immunol. 141: 2635-2642.
  4. Gill H, Prasad J. 2008. Probiotics, immunomodulation, and health benefits. Adv. Exp. Med. Biol. 606: 423-454. https://doi.org/10.1007/978-0-387-74087-4_17
  5. Huang J, Zhong Y, Cai W, Zhang H, Tang W, Chen B. 2010. The effects of probiotics supplementation timing on an ovalbumin-sensitized rat model. FEMS Immunol. Med. Microbiol. 60: 132-141. https://doi.org/10.1111/j.1574-695X.2010.00727.x
  6. Kim H, Kwack K, Kim DY, Ji GE. 2005. Oral probiotic bacterial administration suppressed allergic responses in an ovalbumin-induced allergy mouse model. FEMS Immunol. Med. Microbiol. 45: 259-267. https://doi.org/10.1016/j.femsim.2005.05.005
  7. Kim H, Lee SY, Ji GE. 2005. Timing of Bifidobacterium administration influences the development of allergy to ovalbumin in mice. Biotechnol. Lett. 27: 1361-1367. https://doi.org/10.1007/s10529-005-3682-9
  8. Kim JY, Choi YO, Ji GE. 2008. Effect of oral probiotics (Bifidobacterium lactis AD011 and Lactobacillus acidophilus AD031) administration on ovalbumin-induced food allergy mouse model. J. Microbiol. Biotechnol. 18: 1393-1400.
  9. Lee J, Bang J, Woo HJ. 2013. Immunomodulatory and antiallergic effects of orally administered Lactobacillus species in ovalbumin-sensitized mice. J. Microbiol. Biotechnol. 23: 724-730. https://doi.org/10.4014/jmb.1211.11079
  10. McCaskill AC, Hosking CS, Hill DJ. 1984. Anaphylaxis following intranasal challenge of mice sensitized with ovalbumin. Immunology 51: 669-677.
  11. Murphy KM, Heimberger AB, Loh DY. 1990. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science 250: 1720-1723. https://doi.org/10.1126/science.2125367
  12. Ohno H, Tsunemine S, Isa Y, Shimakawa M, Yamamura H. 2005. Oral administration of Bifidobacterium bifidum G9-1 suppresses total and antigen specific immunoglobulin E production in mice. Biol. Pharm. Bull. 28: 1462-1466. https://doi.org/10.1248/bpb.28.1462
  13. Okamoto A, Kawamura T, Kanbe K, Kanamaru Y, Ogawa H, Okumura K, et al. 2005. Suppression of serum IgE response and systemic anaphylaxis in a food allergy model by orally administered high-dose TGF-beta. Int. Immunol. 17: 705-712. https://doi.org/10.1093/intimm/dxh250
  14. Pene J, Rousset F, Briere F, Chretien I, Wideman J, Bonnefoy JY, et al. 1988. Interleukin 5 enhances interleukin 4-induced IgE production by normal human B cells. The role of soluble CD23 antigen. Eur. J. Immunol. 18: 929-935. https://doi.org/10.1002/eji.1830180615
  15. Peng S, Lin JY, Lin MY. 2007. A ntiallergic effect of m ilk fermented with lactic acid bacteria in a murine animal model. J. Agric. Food Chem. 55: 5092-5096. https://doi.org/10.1021/jf062869s
  16. Poulsen OM, Hau J, Kollerup J. 1987. Effect of homogenization and pasteurization on the allergenicity of bovine milk analysed by a murine anaphylactic shock model. Clin. Allergy 17: 449-458. https://doi.org/10.1111/j.1365-2222.1987.tb02039.x
  17. Powrie F, Coffman RL. 1993. Cytokine regulation of T-cell function: potential for therapeutic intervention. Immunol. Today 14: 270-274. https://doi.org/10.1016/0167-5699(93)90044-L
  18. Shida K, Hachimura S, Ametani A, Ishimori M, Ling M, Hashiguchi M, et al. 2000. Serum IgE response to orally ingested antigen: a novel IgE response model with allergenspecific T-cell receptor transgenic mice. J. Allergy Clin. Immunol. 105: 788-795.
  19. Shida K, Takahashi R, Iwadate E, Takamizawa K, Yasui H, Sato T, et al. 2002. Lactobacillus casei strain Shirota suppresses serum immunoglobulin E and immunoglobulin G1 responses and systemic anaphylaxis in a food allergy model. Clin. Exp. Allergy 32: 563-570. https://doi.org/10.1046/j.0954-7894.2002.01354.x
  20. Sokol CL, Barton GM, Farr AG, Medzhitov R. 2008. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat. Immunol. 9: 310-318. https://doi.org/10.1038/ni1558
  21. Temblay JN, Bertelli E, Arques JL, Regoli M, Nicoletti C. 2007. Production of IL-12 by Peyer patch-dendritic cells is critical for the resistance to food allergy. J. Allergy Clin. Immunol. 120: 659-665.

Cited by

  1. Allergy and the microbiome of the intestine - part II vol.58, pp.4, 2013, https://doi.org/10.1016/s0415-6412(15)30066-7
  2. SLE: Another Autoimmune Disorder Influenced by Microbes and Diet? vol.6, pp.None, 2015, https://doi.org/10.3389/fimmu.2015.00608
  3. Induction of Regulatory Dendritic Cells by Lactobacillus paracasei L9 Prevents Allergic Sensitization to Bovine β-Lactoglobulin in Mice vol.25, pp.10, 2013, https://doi.org/10.4014/jmb.1503.03022
  4. Probiotics and diseases of altered IgE regulation: A short review vol.13, pp.2, 2013, https://doi.org/10.3109/1547691x.2015.1044053
  5. The regulation of immune cells by Lactobacilli: a potential therapeutic target for anti-atherosclerosis therapy vol.8, pp.35, 2013, https://doi.org/10.18632/oncotarget.18346
  6. Preventive Effects of a Probiotic Mixture in an Ovalbumin-Induced Food Allergy Model vol.28, pp.1, 2013, https://doi.org/10.4014/jmb.1708.08051
  7. A Comprehensive Review on Natural Bioactive Compounds and Probiotics as Potential Therapeutics in Food Allergy Treatment vol.11, pp.None, 2013, https://doi.org/10.3389/fimmu.2020.00996
  8. Immune-Inflammation in Atherosclerosis: A New Twist in an Old Tale vol.20, pp.4, 2013, https://doi.org/10.2174/1871530319666191016095725
  9. Dietary Supplementation of Probiotic Lactobacillus acidophilus Modulates Cholesterol Levels, Immune Response, and Productive Performance of Laying Hens vol.10, pp.9, 2013, https://doi.org/10.3390/ani10091588