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Nutritional Support in Acute Pancreatitis

급성 췌장염의 영양요법

  • Park, Eun Taek (Department of Internal Medicine, Gospel Hospital, Kosin University College of Medicine)
  • 박은택 (고신대학교 의과대학 복음병원 내과)
  • Published : 2013.08.01

Abstract

Acute pancreatitis is an inflammatory disease of the pancreas. Acute abdominal pain is the most common symptom, and increased concentrations of serum amylase and lipase confirm the diagnosis. Pancreatic injury is mild in 80% of patients, who recover without complications. The remaining patients have a severe disease with local and systemic complications. Acute pancreatitis is a hypercatabolic state resulting in rapid loss of body weight, fat and protein. Nutritional support is an integral part of patient care and is started early in the course of disease. Patients with mild to moderate disease (80% of patients) do not require enteral nutrition (EN) or parenteral nutrition (PN), as they will begin oral feeding within 4 days of presentation. Nutritional support is needed for severe disease, EN is preferred over PN, and use PN when EN is contraindicated or not feasible. Most groups have used nasojejunal feeding, which has difficulties in maintenance of the tube position and patency. Nasogastric feeding in severe acute pancreatitis has shown little difference in terms of clinical outcome from nasojejunal feeding. In this review, we review the role, methods, and clinical implications of nutritional supports in acute pancreatitis and also present recently recommended standard guidelines.

Keywords

References

  1. Kim TH. Medical treatment of acute pancreatitis. Korean J Med 2008;75:280-284.
  2. Kim YT. Medical management of acute pancreatitis and compications. Korean J Gastroenterol 2005;46:339-344.
  3. Lee SK. Medical treatments of necrotizing pancreatitis. Korean J Med 2007;73:237-242.
  4. DiMagno MJ, DiMagno EP. New advances in acute pancreatitis. Curr Opin Gastroenterol 2007;23:494-501.
  5. Frossard JL, Steer ML, Pastor CM. Acute pancreatitis. Lancet 2008;371:143-152. https://doi.org/10.1016/S0140-6736(08)60107-5
  6. Banks PA, Freeman ML; Practice Parameters Committee of the American College of Gastroenterology. Practice guidelines in acute pancreatitis. Am J Gastroenterol 2006;101: 2379-2400. https://doi.org/10.1111/j.1572-0241.2006.00856.x
  7. Talukdar R, Swaroop Vege S. Early management of severe acute pancreatitis. Curr Gastroenterol Rep 2011;13:123-130. https://doi.org/10.1007/s11894-010-0174-4
  8. Qin RY, Qiu FZ. Imaging changes of the pancreas and the occasion of refeeding in patients with acute pancreatitis. Hepatobiliary Pancreat Dis Int 2002;1:290-293.
  9. Jacobson BC, Vander Vliet MB, Hughes MD, Maurer R, McManus K, Banks PA. A prospective, randomized trial of clear liquids versus low-fat solid diet as the initial meal in mild acute pancreatitis. Clin Gastroenterol Hepatol 2007;5: 946-951. https://doi.org/10.1016/j.cgh.2007.04.012
  10. Sathiaraj E, Murthy S, Mansard MJ, Rao GV, Mahukar S, Reddy DN. Clinical trial: oral feeding with a soft diet compared with clear liquid diet as initial meal in mild acute pancreatitis. Aliment Pharmacol Ther 2008;28:777-781. https://doi.org/10.1111/j.1365-2036.2008.03794.x
  11. Eckerwall GE, Tingstedt BB, Bergenzaun PE, Andersson RG. Immediate oral feeding in patients with mild acute pancreatitis is safe and may accelerate recovery: a randomized clinical study. Clin Nutr 2007;26:758-763. https://doi.org/10.1016/j.clnu.2007.04.007
  12. Baik HW. Nutritional therapy in gastrointestinal disease. Korean J Gastroenterol 2004;43:331-340.
  13. Meier R, Ockenga J, Pertkiewicz M, Pap A, Milinic N, Macfie J. ESPEN guidelines on enteral nutrition: pancreas. Clin Nutr 2006;25:275-284. https://doi.org/10.1016/j.clnu.2006.01.019
  14. Gianotti L, Meier R, Lobo DN, et al. ESPEN guidelines on parenteral nutrition: pancreas. Clin Nutr 2009;28:428-435. https://doi.org/10.1016/j.clnu.2009.04.003
  15. Hallay J, Kovacs G, Szatmari K, et al. Early jejunal nutrition and changes in the immunological parameters of patients with acute pancreatitis. Hepatogastroenterology 2001;48: 1488-1492.
  16. Olah A, Belagyi T, Issekutz A, Gamal ME, Bengmark S. Randomized clinical trial of specific lactobacillus and fibre supplement to early enteral nutrition in patients with acute pancreatitis. Br J Surg 2002;89:1103-1107. https://doi.org/10.1046/j.1365-2168.2002.02189.x
  17. Takeda K, Takada T, Kawarada Y, et al. JPN guidelines for the management of acute pancreatitis: medical management of acute pancreatitis. J Hepatobiliary Pancreat Surg 2006; 13:42-47. https://doi.org/10.1007/s00534-005-1050-8
  18. Sekimoto M, Shikata S, Takada T, et al. Changes in management of acute pancreatitis before and after the publication of evidence-based practice guidelines in 2003. J hepatobiliary Pancreat Sci 2010;17:17-23. https://doi.org/10.1007/s00534-009-0212-5
  19. Pezzilli R, Simoni P, Casadei R, Morselli-Labate AM. Exocrine pancreatic function during the early recovery phase of acute pancreatitis. Hepatobiliary Pancreat Dis Int 2009;8:316-319.