The Korean Journal of Medicine

  • 제84권6호
  • /
  • Pages.802-803
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  • 2013
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  • 1738-9364(pISSN)
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  • 2289-0769(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
권호 표지
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졸피뎀, 과연 안전한 불면증 치료제인가?

Zolpidem, Is it a Safe Drug for Insomnia Management?

  • 박경희 (연세대학교 의과대학 내과학교실, 세브란스병원 지역의약품안전센터) ;
  • 이재현 (연세대학교 의과대학 내과학교실, 세브란스병원 지역의약품안전센터)
  • Park, Kyung Hee (Department of Internal Medicine, Severance Hospital Regional Pharmacovigilance Center, Yonsei University College of Medicine) ;
  • Lee, Jae-Hyun (Department of Internal Medicine, Severance Hospital Regional Pharmacovigilance Center, Yonsei University College of Medicine)
  • 발행 : 2013.06.01
⟨ 이전 논문 다음 논문 ⟩

초록

Zolpidem is one of commonly prescribed hypnotics in worldwide. Zolpidem is more favored than benzodiazepines because of its efficacy and safety profiles. However there were many reports those concerns about adverse drug reactions such as delirium, nightmares and hallucinations. The report of Kim et al. showed that zolpidem induced delirium occurred in 4.0% in inpatients. Moreover, old age and concomitant use of benzodiazepine were risk factors for zolpidem related delirium. Therefore, clinicians carefully consider the risk factors when prescribe zolpidem, and the careful monitoring of patients about various adverse reactions after administration.

키워드

참고문헌

  1. De Haas SL, Schoemaker RC, van Gerven JM, Hoever P, Cohen AF, Dingemanse J. Pharmacokinetics, pharmacodynamics and the pharmacokinetic/ pharmacodynamic relationship of zolpidem in healthy subjects. J Psychopharmacol 2010;24:1619-1629. https://doi.org/10.1177/0269881109106898
  2. Toner LC, Tsambiras BM, Catalano G, Catalano MC, Cooper DS. Central nervous system side effects associated with zolpidem treatment. Clin Neuropharmacol 2000;23: 54-58. https://doi.org/10.1097/00002826-200001000-00011
  3. Brodeur MR, Stirling AL. Delirium associated with zolpidem. Ann Pharmacother 2001;35:1562-1564. https://doi.org/10.1345/aph.10385
  4. Paradis CM, Siegel LA, Kleinman SB. Two cases of zolpidem- associated homicide. Prim Care Companion CNS Disord 2012;14. pii: PCC.12br01363.
  5. Kang DY, Park S, Rhee CW, et al. Zolpidem use and risk of fracture in elderly insomnia patients. J Prev Med Public Health 2012;45:219-226. https://doi.org/10.3961/jpmph.2012.45.4.219
  6. Kolla BP, Lovely JK, Mansukhani MP, Morgenthaler TI. Zolpidem is independently associated with increased risk of inpatient falls. J Hosp Med 2013;8:1-6. https://doi.org/10.1002/jhm.1985
  7. Kim YM, Lee SR, Jung JY, et al. Incidence and Risk Factors of Zolpidem-Induced Delirium. Korean J Med 2013;84: 804-809. https://doi.org/10.3904/kjm.2013.84.6.804
  8. FDA requires lower dosing of zolpidem. Med Lett Drugs Ther 2013;55:5.

피인용 문헌

  1. 황칠(黃漆) 약침이 정신 스트레스를 받은 백서의 수면 관련 호르몬, 인지에 미치는 영향 vol.30, pp.4, 2019, https://doi.org/10.7231/jon.2019.30.4.341