The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Weight Gain and Improvement of Osteoporosis with Anti-TNF Therapy

Anti-TNF-${\alpha}$ 치료받은 강직성 척추염에서 체중 및 골밀도 변화

  • Kim, Tae-Hwan (Hanyang University Hospital for Rheumatic Diseases, Hanyang University College of Medicine) ;
  • Yun, Hyaejin (Hanyang University Hospital for Rheumatic Diseases, Hanyang University College of Medicine)
  • 김태환 (한양대학교 류마티스병원) ;
  • 윤혜진 (한양대학교 류마티스병원)
  • Published : 2013.11.01
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Abstract

Ankylosing spondylitis (AS) is a chronic inflammatory disorder primarily involving the sacroiliac joints and spine. It usually affects young people, and bone formation and resorption are implicated in the pathogenesis of AS. Non-steroidal anti-inflammatory drugs (NSAIDs) are the first line therapy and are very effective in most of patients who have inflammatory back pain. If NSAIDs are not effective, anti-TNF-${\alpha}$ agents are strongly recommended in severe inflammatory back pain. Anti-TNF-${\alpha}$ is very effective in most of AS patients. A study by Lee et al. showed that AS patients who were treated with anti-TNF-${\alpha}$ have weight gain and improvement of osteoporosis. In this editorial, studies on the improvement of weight and osteoporosis with anti-TNF-${\alpha}$ agents are reviewed.

Keywords

References

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