DOI QR코드

DOI QR Code

Association Between Colon Diverticulosis and Development of Colorectal Cancer

대장게실과 대장암 발생과의 상관관계

  • Kim, Tae-Oh (Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine)
  • 김태오 (인제대학교 의과대학 해운대백병원 내과)
  • Published : 2013.12.01

Abstract

The prevalence of colorectal cancer (CRC) and diverticular disease has increased in recent years. Both have common risk factors such as age and a lack of dietary fiber. A causal relationship between diverticulosis and CRC has been suggested in different studies. Despite common epidemiological trends and risk factors, there are conflicting data concerning the association between diverticular disease and CRC. Such discrepancy could be referred to the highly heterogeneous study design and setting in the diff erent epidemiologic series. Unravelling the dilemma seems to be clinically relevant, because a different screening and/or surveillance protocol for CRC could be scheduled in patients with diverticula. The present review aimed to perform a comprehensive evaluation of the available data.

Keywords

References

  1. Stollman NH, Raskin JB. Diverticular disease of the colon. J Clin Gastroenterol 1999;29:241-252. https://doi.org/10.1097/00004836-199910000-00004
  2. Parra-Blanco A. Colonic diverticular disease: pathophysiology and clinical picture. Digestion 2006;73(Suppl 1):47-57.
  3. Heise CP. Epidemiology and pathogenesis of diverticular disease. J Gastrointest Surg 2008;12:1309-1311. https://doi.org/10.1007/s11605-008-0492-0
  4. Wagner DE, Zollinger RW. Diverticulitis of the cecum and ascending colon. Arch Surg 1961;83:436-443. https://doi.org/10.1001/archsurg.1961.01300150110014
  5. Burkitt DP, Walker AR, Painter NS. Effect of dietary fibre on stools and the transit-times, and its role in the causation of disease. Lancet 1972;30:1408-1412.
  6. McCallum A, Eastwood MA, Smith AN, Fulton PM. Colonic diverticulosis in patients with colorectal cancer and in controls. Scand J Gastroenterol 1988;23:284-286. https://doi.org/10.3109/00365528809093866
  7. Morini S, de Angelis P, Manurita L, Colavolpe V. Association of colonic diverticula with adenomas and carcinomas: a colonoscopic experience. Dis Colon Rectum 1988;31:793-796. https://doi.org/10.1007/BF02560109
  8. Stefánsson T, Ekbom A, Sparèn P, Påhlman L. Increased risk of left sided colon cancer in patients with diverticular disease. Gut 1993;34:499-502. https://doi.org/10.1136/gut.34.4.499
  9. Kim KS, Lee KS, Choi SS, Song IS. Recent changes of colonic diverticulosis in Korea. J Korean Radiol Soc 1984; 20:632-638. https://doi.org/10.3348/jkrs.1984.20.3.632
  10. Kim KH, Kim YB, Kang JK, Kim SJ. A clinical study of diverticulosis of the colon. J Korean Med Assoc 1986;29: 63-68.
  11. Kim BH, Lee SH, Lee SS, Oh DJ, Chung ES, Lee SJ. Diverticular disease of the colon in Korea. Korean J Intern Med 1987;2:79-83. https://doi.org/10.3904/kjim.1987.2.1.79
  12. Kwoen YT, Han SI, Chung SK, Bahk YW. Changing incidence of diverticular disease of the colon in Korea: a serial radiologic study (report iii). J Korean Radiol Soc 1988;24:840-843. https://doi.org/10.3348/jkrs.1988.24.5.840
  13. Lee YJ, Kim GW, Ryu BY, et al. The incidence and characteristics of colonic diverticulosis in the west Kangwondo. J Korean Surg Soc 1990;39:121-132.
  14. Son MY, Chang JC, Hwang MS, Kim SW, Park BH, Sim MC. Radiologic analysis of developmental pattern in colonic diverticulosis. Korean J Gastroenterol 1990;22:94-99.
  15. Ko JK, Lee JK, Yun EJ, Moon HJ, Shin HJ. Colonic diverticulosis: evaluation with double contrast barium enema. J Korean Radiol Soc 1997;36:285-289. https://doi.org/10.3348/jkrs.1997.36.2.285
  16. Choi CS, Cho EY, Kweon JH, et al. The prevalence and clinical features of colonic diverticulosis diagnosed with colonscopy. Korean J Gastrointest Endosc 2007;35:146-151.
  17. Smith AN. Colonic muscle in diverticular disease. Clic Gastroenterol 1986;15:917-935.
  18. Ames BN, Gold LS. Too many rodent carcinogens: mitogenesis increases mutagenesis. Science 1990;249:970-971. https://doi.org/10.1126/science.2136249
  19. Choi CS, Choi SC, Seo GS, et al. Association between Diverticulosis and Colonic Neoplasm in Koreans. Korean J Gastroenterol 2007;49:364-368.
  20. Lam TJ, Meurs-Szojda MM, Gundlach L, et al. There is no increased risk for colorectal cancer and adenomas in patients with diverticulitis: a retrospective longitudinal study. Colorectal Dis 2010;12:1122-1126. https://doi.org/10.1111/j.1463-1318.2009.01992.x
  21. Loffeld RJ, Van Der Putten AB. Diverticular disease of the colon and concomitant abnormalities in patients undergoing endoscopic evaluation of the large bowel. Colorectal Dis 2002;4:189-192. https://doi.org/10.1046/j.1463-1318.2002.00328.x
  22. Meurs-Szojda MM, Terhaar sive Droste JS, Kuik DJ, Mulder CJ, Felt-Bersma RJ. Diverticulosis and diverticulitis form no risk for polyps and colorectal neoplasia in 4,241 colonoscopies. Int J Colorectal Dis 2008;23:979-984. https://doi.org/10.1007/s00384-008-0510-4
  23. Granlund J, Svensson T, Granath F, et al. Diverticular disease and the risk of colon cancer-a population-based case-control study. Aliment Pharmacol Ther 2011;34:675-681. https://doi.org/10.1111/j.1365-2036.2011.04782.x
  24. Stefansson T, Ekbom A, Sparen P, Pahlman L. Association between sigmoid diverticulitis and left-sided colon cancer: a nested, population-based, case control study. Scand J Gastroenterol 2004;39:743-747. https://doi.org/10.1080/00365520410003272