Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Evaluation of the Systemic Oxidative Stress Status during Major Orthopedic Surgery in Dogs: A Clinical Study

개에서 정형외과 수술에 따른 전신 산화스트레스 상태의 평가

  • 이재연 (충남대학교 수의과대학.동물의과학연구소) ;
  • 원흥석 (마크로 24시 동물병원) ;
  • 황학균 (케나인 동물병원) ;
  • 정성목 (충남대학교 수의과대학.동물의과학연구소) ;
  • 김명철 (충남대학교 수의과대학.동물의과학연구소)
  • Accepted : 2013.02.14
  • Published : 2013.02.28
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Abstract

The present study evaluated the systemic oxidative stress status during major orthopedic surgery in dogs. Sixteen dogs presented with various orthopedic diseases involving fractures or luxation of limbs. All patients underwent orthopedic surgery for treatment of fractures or luxation of limbs. A significant increase in the plasma total oxidant status (TOS) and oxidative stress index (OSI) levels in dogs after surgery was observed. Plasma total antioxidant status (TAS) levels were significantly decreased in dogs after surgery. The results of this study suggested that association or relationship in serum between TOS or TAS levels and redox imbalance were caused by surgical trauma in orthopedic disease conditions.

본 연구는 개에서 주요 정형외과 수술에 따른 전신 산화 스트레스 상태를 평가하였다. 16 마리의 골절이나 사지의 탈구 질환을 포함하는 환축을 대상으로 연구를 실시하였고 모든 환축은 골절이나 탈구의 치료를 위해 다양한 정형외과 수술을 받았다. 수술 후 혈장 총 산화상태(total oxidant status, TOS) 및 산화스트레스 지수(oxidative stress index, OSI)에서 유의적인 증가가 확인되었다. 수술 후 혈장 총 항산화상태(total antioxidant status, TAS)에서 유의적인 감소를 확인하였다. 본 연구를 통해 정형외과 수술외상에 따른 혈장 내 총 산화 및 항산화 상태가 산화스트레스와 관련 있음을 확인 할 수 있었다.

Keywords

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