Radiation Oncology Journal

The Korean Society for Radiation Oncology (대한방사선종양학회)
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Stereotactic body radiotherapy for solitary spine metastasis

  • Lee, Sunyoung (Department of Radiation Oncology, Sun Medical Center) ;
  • Chun, Mison (Department of Radiation Oncology, Ajou University School of Medicine) ;
  • Lee, MiJo (Department of Radiation Oncology, Eulji Universtiy School of Medicine)
  • Received : 2013.08.09
  • Accepted : 2013.12.06
  • Published : 2013.12.31
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Abstract

A clear consensus has not been established regarding the best treatment for solitary bone metastasis. Here, we reviewed the medical records of patients with a controlled primary malignancy who had only solitary spine metastasis without metastasis to the extraspinal bone or viscera and underwent treatment between April 2007 and December 2012 with stereotactic body radiosurgery using CyberKnife, with a total dose of 24 Gy in three to four fractions. During that time, there were only four cases. This was effective in each case, and all the four patients had no local failure and remained alive at a median follow-up of 68 months (range, 64 to 80 months). Although our experience is limited, this study suggests that stereotactic body radiotherapy could be a feasible, safe, effective, and noninvasive alternative treatment for solitary spine metastasis in patients who are medically inoperable or unsuitable for surgery.

Keywords

References

  1. Rubin P, Brasacchio R, Katz A. Solitary metastases : illusion versus reality. Semin Radiat Oncol 2006;16:120-30. https://doi.org/10.1016/j.semradonc.2005.12.007
  2. Pakos EE, Gartzonikas DN, Tsekeris PG, Xenakis TA. Solitary tibial osteolytic lesion. Case Rep Med 2009;2009:352085.
  3. Tomita K, Kawahara N, Kobayashi T, Yoshida A, Murakami H, Akamaru T. Surgical strategy for spinal metastases. Spine (Phila Pa 1976) 2001;26:298-306. https://doi.org/10.1097/00007632-200102010-00016
  4. Sakaura H, Hosono N, Mukai Y, Ishii T, Yonenobu K, Yoshikawa H. Outcome of total en bloc spondylectomy for solitary metastasis of the thoracolumbar spine. J Spinal Disord Tech 2004;17:297-300. https://doi.org/10.1097/01.bsd.0000096269.75373.9b
  5. Melcher I, Disch AC, Khodadadyan-Klostermann C, et al. Primary malignant bone tumors and solitary metastases of the thoracolumbar spine: results by management with total en bloc spondylectomy. Eur Spine J 2007;16:1193-202. https://doi.org/10.1007/s00586-006-0295-5
  6. Sundaresan N, Rothman A, Manhart K, Kelliher K. Surgery for solitary metastases of the spine: rationale and results of treatment. Spine (Phila Pa 1976) 2002;27:1802-6. https://doi.org/10.1097/00007632-200208150-00021
  7. Chawla S, Abu-Aita R, Philip A, Lundquist T, Okunieff P, Milano MT. Stereotactic radiosurgery for spinal metastases: case report and review of treatment options. Bone 2009;45:817-21. https://doi.org/10.1016/j.bone.2009.06.013
  8. Sahgal A, Larson DA. Chang EL. Stereotactic body radiosurgery for spinal metastases: a critical review. Int J Radiat Oncol Biol Phys 2008;71:652-65. https://doi.org/10.1016/j.ijrobp.2008.02.060
  9. Gerszten PC, Burton SA. Ozhasoglu C, Welch WC. Radiosurgery for spinal metastases: clinical experience in 500 cases from a single institution. Spine (Phila Pa 1976) 2007;32:193-9. https://doi.org/10.1097/01.brs.0000251863.76595.a2
  10. Chang EL, Shiu AS, Mendel E, et al. Phase l/ll study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure. J Neurosurg Spine 2007;7:151-60. https://doi.org/10.3171/SPI-07/08/151
  11. Yamada Y, Bilsky MH, Lovelock DM, et al. High-dose, sing lefraction image-guided intensity-modulated radiotherapy for metastatic spinal lesions. Int J Radiat Oncol Biol Phys 2008;71:484-90. https://doi.org/10.1016/j.ijrobp.2007.11.046
  12. Ryu S, Jin R, Jin JY, et al. Pain control by image-guided radiosurgery for solitary spinal metastasis. J Pain Symptom Manag 2008;35:292-8. https://doi.org/10.1016/j.jpainsymman.2007.04.020
  13. Tokuhashi Y, Matsuzaki H, Toriyama S, Kawano H, Ohsaka S. Scoring system for the preoperative evaluation of metastatic spine tumor prognosis. Spine (Phila Pa 1976) 1990; 15:1110-3. https://doi.org/10.1097/00007632-199011010-00005
  14. Choi D, Crockard A. Bunger C, et al. Review of metastatic spine tumour classification and indications for surgery: the consensus statement of the Global Spine Tumour Study Group. Eur Spine J 2010;19:215-22. https://doi.org/10.1007/s00586-009-1252-x
  15. Wu JS, Wong R, Johnston M, Bezjak A, Whelan T; Cancer Care Ontario Practice Guidelines Initiative Supportive Care Group. Meta-analysis of dose-fractionation radiotherapy trials for the palliation of painful bone metastases. Int J Radiat Oncol Biol Phys 2003;55:594-605. https://doi.org/10.1016/S0360-3016(02)04147-0
  16. Chow E, Harris K, Fan G, Tsao M, Sze WM. Palliative radiotherapy trials for bone metastases: a systematic review. J Clin OncoI 2007;25:1423-36. https://doi.org/10.1200/JCO.2006.09.5281
  17. Lu tz S, Berk L. Chang E, et al. Palliative radiotherapy for bone metastases: an ASTRO evidence-based guideline. Int J Radiat Oncol Biol Phys 2011;79:965-7 6. https://doi.org/10.1016/j.ijrobp.2010.11.026

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