Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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The Coordination of Pyridyl-N to Pentacyanoferrate for the Electrochemical Detecting Small Organic Molecules

  • Choi, Young-Bong (Department of chemistry, College of Advanced Science, Dankook University) ;
  • Jeon, Won-Yong (Department of Nanobiomedical Science & WCU Research Center, Dankook University Graduate School) ;
  • Kim, Hyug-Han (Department of chemistry, College of Advanced Science, Dankook University)
  • Received : 2012.11.07
  • Accepted : 2012.12.03
  • Published : 2013.02.20
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Abstract

The coordination of pyridyl-N to pentacyanoferrate for the detection of small organic antigens in solution is presented. The unique contribution of this paper is the direct conjugation of pyridyl-N in small organic antigens to pentacyanoferrate. Pentacyanoferrate is promising as an electrochemical label owing to its good electro-chemical properties, which can be utilized to generate an electrical signal in homogeneous electrochemical immunoassays. The facilely synthesized pyridyl-N to pentacyanoferrate was characterized by the electrochemical and spectroscopic methods. Hippuric acid (HA) has been detected competitively on the interaction of free HA and pentacyanoferrate-(4-aminomethylpyridine-hippuric acid) (Fe-HA) to its antibody, with the detection limit of 0.50 ${\mu}g\;mL^{-1}$. While pentacyanoferrate-based immunoassay is in its simplicity and infancy, the proposed immunoassay offers attractive opportunities for developing pyridyl-N-based the electrochemical detection of small organic antigens in the health care area.

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