Bulletin of the Korean Chemical Society

  • 제34권2호
  • /
  • Pages.585-589
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  • 2013
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Microwave Synthesis of Chiral N-Benzyl-2-methyl-2H-benzo[b][1,4]oxazin/thiazin-3(4H)-ones via Smiles Rearrangement and their Biological Evaluation

  • Meng, Li-Juan (Departments of Chemistry and Physics, Changwon National University) ;
  • Zuo, Hua (College of Pharmaceutical Sciences, Southwest University) ;
  • Vijaykumar, B.V.D. (Departments of Chemistry and Physics, Changwon National University) ;
  • Dupati, Gautam (Departments of Chemistry and Physics, Changwon National University) ;
  • Choi, Kyung-Min (Departments of Chemistry and Physics, Changwon National University) ;
  • Jang, Kiwan (Departments of Chemistry and Physics, Changwon National University) ;
  • Yoon, Yong-Jin (Department of Chemistry, Gyeongsang National University) ;
  • Shin, Dong-Soo (Departments of Chemistry and Physics, Changwon National University)
  • 투고 : 2012.10.10
  • 심사 : 2012.11.29
  • 발행 : 2013.02.20
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초록

Optically active N-benzyl-2-methyl-2H-benzo[b][1,4]oxazin-3(4H)-ones and N-benzyl-2-methyl-2H-benzo[b][1,4]thiazin-3(4H)-ones with potential synthetic and pharmacological interest were prepared via Smiles rearrangement in conventional as well as microwave irradiation conditions in one-pot from inexpensive (S)-2-chloropropionic acid. Most of the compounds displayed good inhibition against Gram positive bacteria and fungi in the antibiotic test.

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