Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Buckwheat Extract Increases Resistance to Oxidative Stress and Lifespan in Caenorhabditis elegans

꼬마선충에서 메밀 추출물에 의한 산화성 스트레스 저항성 증가 및 수명 연장 효과

  • Kim, Chul Kyu (Department of Medical Biotechnology, Soonchunhyang University) ;
  • Park, Sang Kyu (Department of Medical Biotechnology, Soonchunhyang University)
  • 김철규 (순천향대학교 의료생명공학과) ;
  • 박상규 (순천향대학교 의료생명공학과)
  • Received : 2012.10.31
  • Accepted : 2012.12.27
  • Published : 2013.02.28
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Abstract

Buckwheat (Fagopyrum esculentum) has been known for having strong anti-oxidant, anti-mutagenic, and anti-carcinogenic activities. The free radical theory of aging, also known as the oxidative stress theory of aging, claims that cellular oxidative damage accumulated with time is a major causal factor of aging. In the present study, we investigated the effect of buckwheat extracts on resistance to oxidative stress and aging using Caenorhabditis elegans as a model system. Survival under an oxidative-stress condition induced by paraquat increased markedly following 500mg/L buckwheat extracts treatment, suggesting lower cellular oxidative damage by buckwheat extracts. A lifespan assay also revealed that treatment of buckwheat extracts significantly extended both the mean and maximum lifespan in C. elegans. Interestingly, this lifespan-extension by buckwheat extracts was not accompanied by reduced fertility. These findings suggest that buckwheat extracts can confer longevity phenotype to C. elegans through its strong anti-oxidant activity and support the aging theory which emphasizes a pivotal role of oxidative stress during aging.

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References

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