IMMUNE NETWORK

  • 제13권5호
  • /
  • Pages.218-221
  • /
  • 2013
  • /
  • 1598-2629(pISSN)
  • /
  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
권호 표지
DOI QR코드

DOI QR Code

B Cells Promote Th1- Skewed NKT Cell Response by CD1d-TCR Interaction

  • Shin, Jung Hoon (School of Life Sciences and Biotechnology, Korea University) ;
  • Park, Se-Ho (School of Life Sciences and Biotechnology, Korea University)
  • 투고 : 2013.09.11
  • 심사 : 2013.10.07
  • 발행 : 2013.10.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

CD1d expressing dendritic cells (DCs) are good glyco-lipid antigen presenting cells for NKT cells. However, resting B cells are very weak stimulators for NKT cells. Although ${\alpha}$-galactosylceramide (${\alpha}$-GalCer) loaded B cells can activate NKT cells, it is not well defined whether B cells interfere NKT cell stimulating activity of DCs. Unexpectedly, we found in this study that B cells can promote Th1-skewed NKT cell response, which means a increased level of IFN-${\gamma}$ by NKT cells, concomitant with a decreased level of IL-4, in the circumstance of co-culture of DCs and B Cells. Remarkably, the response promoted by B cells was dependent on CD1d expression of B cells.

키워드

참고문헌

  1. Bendelac, A., M. N. Rivera, S. H. Park, and J. H. Roark. 1997. Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu. Rev. Immunol. 15: 535-562. https://doi.org/10.1146/annurev.immunol.15.1.535
  2. De Libero, G. and L. Mori. 2005. Recognition of lipid antigens by T cells. Nat. Rev. Immunol. 5: 485-496. https://doi.org/10.1038/nri1631
  3. Bendelac, A., P. B. Savage, and L. Teyton. 2007. The biology of NKT cells. Annu. Rev. Immunol. 25: 297-336. https://doi.org/10.1146/annurev.immunol.25.022106.141711
  4. Shin, Y., C. Hong, H. Lee, J. H. Shin, S. Hong, and S. H. Park. 2010. NKT cell-dependent regulation of secondary antigen- specific, conventional CD4+ T cell immune responses. J. Immunol. 184: 5589-5594. https://doi.org/10.4049/jimmunol.0903121
  5. Hong, C., H. Lee, M. Oh, C. Y. Kang, S. Hong, and S. H. Park. 2006. CD4+ T cells in the absence of the CD8+ cytotoxic T cells are critical and sufficient for NKT cell-dependent tumor rejection. J. Immunol. 177: 6747-6757. https://doi.org/10.4049/jimmunol.177.10.6747
  6. Hong, C., H. Lee, Y. K. Park, J. Shin, S. Jung, H. Kim, S. Hong, and S. H. Park. 2009. Regulation of secondary antigen- specific CD8(+) T-cell responses by natural killer T cells. Cancer Res. 69: 4301-4308. https://doi.org/10.1158/0008-5472.CAN-08-1721
  7. Fujii, S., K. Shimizu, M. Kronenberg, and R. M. Steinman. 2002. Prolonged IFN-gamma-producing NKT response induced with alpha-galactosylceramide-loaded DCs. Nat. Immunol. 3: 867-874. https://doi.org/10.1038/ni827
  8. Bezbradica, J. S., A. K. Stanic, N. Matsuki, H. Bour-Jordan, J. A. Bluestone, J. W. Thomas, D. Unutmaz, L. Van Kaer, and S. Joyce. 2005. Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo. J. Immunol. 174: 4696-4705. https://doi.org/10.4049/jimmunol.174.8.4696
  9. Leadbetter, E. A., M. Brigl, P. Illarionov, N. Cohen, M. C. Luteran, S. Pillai, G. S. Besra, and M. B. Brenner. 2008. NK T cells provide lipid antigen-specific cognate help for B cells. Proc. Natl. Acad. Sci. 105: 8339-8344. https://doi.org/10.1073/pnas.0801375105
  10. Barral, P., J. Eckl-Dorna, N. E. Harwood, C. De Santo, M. Salio, P. Illarionov, G. S. Besra, V. Cerundolo, and F. D. Batista. 2008. B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo. Proc. Natl. Acad. Sci. USA. 105: 8345-8350. https://doi.org/10.1073/pnas.0802968105
  11. King, I. L., A. Fortier, M. Tighe, J. Dibble, G. F. Watts, N. Veerapen, A. M. Haberman, G. S. Besra, M. Mohrs, M. B. Brenner, and E. A. Leadbetter. 2011. Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner. Nat. Immunol. 13: 44-50. https://doi.org/10.1038/ni.2172
  12. Chung, Y., B. S. Kim, Y. J. Kim, H. J. Ko, S. Y. Ko, D. H. Kim, and C. Y. Kang. 2006. CD1d-restricted T cells license B cells to generate long-lasting cytotoxic antitumor immunity in vivo. Cancer Res. 66: 6843-6850. https://doi.org/10.1158/0008-5472.CAN-06-0889
  13. Kim, Y. J., H. J. Ko, Y. S. Kim, D. H. Kim, S. Kang, J. M. Kim, Y. Chung, and C. Y. Kang. 2008. alpha-Galactosylceramide- loaded, antigen-expressing B cells prime a wide spectrum of antitumor immunity. Int. J. Cancer. 122: 2774-2783. https://doi.org/10.1002/ijc.23444
  14. Diaz-de-Durana, Y., G. T. Mantchev, R. J. Bram, and A. Franco. 2006. TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo. Blood 107: 594-601. https://doi.org/10.1182/blood-2004-12-4708
  15. Bialecki, E., C. Paget, J. Fontaine, M. Capron, F. Trottein, and C. Faveeuw. 2009. Role of marginal zone B lymphocytes in invariant NKT cell activation. J. Immunol. 182: 6105-6113. https://doi.org/10.4049/jimmunol.0802273
  16. Chuang, Y. H., T. C. Wang, H. Y. Jen, A. L. Yu, and B. L. Chiang. 2011. alpha-Galactosylceramide-induced airway eosinophilia is mediated through the activation of NKT cells. J. Immunol. 186: 4687-4692. https://doi.org/10.4049/jimmunol.1003659
  17. Hachem, P., M. Lisbonne, M. L. Michel, S. Diem, S. Roongapinun, J. Lefort, G. Marchal, A. Herbelin, P. W. Askenase, M. Dy, and M. C. Leite-de-Moraes. 2005. Alphagalactosylceramide- induced iNKT cells suppress experimental allergic asthma in sensitized mice: role of IFN-gamma. Eur. J. Immunol. 35: 2793-2802. https://doi.org/10.1002/eji.200535268
  18. Matsuda, H., T. Suda, J. Sato, T. Nagata, Y. Koide, K. Chida, and H. Nakamura. 2005. alpha-Galactosylceramide, a ligand of natural killer T cells, inhibits allergic airway inflammation. Am. J. Respir. Cell. Mol. Biol. 33: 22-31. https://doi.org/10.1165/rcmb.2004-0010OC

피인용 문헌

  1. NKT cells mediate the recruitment of neutrophils by stimulating epithelial chemokine secretion during colitis vol.474, pp.2, 2013, https://doi.org/10.1016/j.bbrc.2016.04.024