IMMUNE NETWORK

  • 제13권1호
  • /
  • Pages.34-41
  • /
  • 2013
  • /
  • 1598-2629(pISSN)
  • /
  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
권호 표지
DOI QR코드

DOI QR Code

Modulation of Humoral and Cell-Mediated Immunity Against Avian Influenza and Newcastle Disease Vaccines by Oral Administration of Salmonella enterica Serovar Typhimurium Expressing Chicken Interleukin-18

  • Rahman, Md Masudur (College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University) ;
  • Uyangaa, Erdenebileg (College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University) ;
  • Eo, Seong Kug (College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University)
  • 투고 : 2013.01.22
  • 심사 : 2013.02.08
  • 발행 : 2013.02.28
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Interleukin-18 (IL-18) has been known to induce interferon-${\gamma}$ (IFN-${\gamma}$) production and promote Th1 immunity. Although mammalian IL-18 has been characterized in great detail, the properties and application of chicken IL-18 remain largely uninvestigated as of yet. In this study, we evaluated the immunomodulatory properties of Salmonella enterica serovar Typhimurium expressing chicken interleukin-18 (chIL-18) on immune responses induced by avian influenza (AI) and Newcastle disease (ND) vaccines. After oral administration of S. enterica serovar Typhimurium expressing chIL-18, chickens were vaccinated intramuscularly with the recommended dose of either inactivated AI H9N2 vaccine or ND (B1 strain) vaccine. Chickens receiving a primary vaccination were boosted using the same protocol 7 days later. Humoral and cell-mediated immune responses were evaluated in terms of HI antibody titers and proliferation and mRNA expression of IFN-${\gamma}$ and IL-4 of peripheral blood mononuclear cells (PBMC) in response to specific antigen stimulation. According to our results, oral administration of S. enterica serovar Typhimurium expressing chIL-18 induced enhanced humoral and Th1-biased cell-mediated immunity against AI and ND vaccines, compared to that of chickens received S. enterica serovar Typhimurium harboring empty vector. Therefore, we conclude that our proposed vaccination regimen using inactivated AI and ND viruses along with oral administration of S. enterica serovar Typhimurium expressing chIL-18 may provide a novel approach in protecting chicken from currently circulating AI and ND virus strains.

키워드

참고문헌

  1. Fouchier, R. A., V. Munster, A. Wallensten, T. M. Bestebroer, S. Herfst, D. Smith, G. F. Rimmelzwaan, B. Olsen, and A. D. Osterhaus. 2005. Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from black-headed gulls. J. Virol. 79: 2814-2822. https://doi.org/10.1128/JVI.79.5.2814-2822.2005
  2. Alexander, D. J. 2000. A review of avian influenza in different bird species. Vet. Microbiol. 74: 3-13. https://doi.org/10.1016/S0378-1135(00)00160-7
  3. Butt, K. M., G. J. Smith, H. Chen, L. J. Zhang, Y. H. Leung, K. M. Xu, W. Lim, R. G. Webster, K. Y. Yuen, J. S. Peiris, and Y. Guan. 2005. Human infection with an avian H9N2 influenza A virus in Hong Kong in 2003. J. Clin. Microbiol. 43: 5760-5767. https://doi.org/10.1128/JCM.43.11.5760-5767.2005
  4. Li, K. S., K. M. Xu, J. S. Peiris, L. L. Poon, K. Z. Yu, K. Y. Yuen, K. F. Shortridge, R. G. Webster, and Y. Guan. 2003. Characterization of H9 subtype influenza viruses from the ducks of southern China: a candidate for the next influenza pandemic in humans? J. Virol. 77: 6988-6994. https://doi.org/10.1128/JVI.77.12.6988-6994.2003
  5. Alexander, D. J. 2003. Newcastle disease, other avian Paramyxoviruses, and Pneumovirusinfections. In Y. M. Saif, ed. Diseases of poultry, 11th ed. IowaState Press, IA. p. 63-87.
  6. Senne, D. A., D. J. King, and D. R. Kapczynski. 2004. Control of Newcastle disease by vaccination. Dev. Biol. (Basel). 119: 165-170.
  7. van Boven, M., A. Bouma, T. H. Fabri, E. Katsma, L. Hartog, and G. Koch. 2008. Herd immunity to Newcastle disease virus in poultry by vaccination. Avian. Pathol. 37: 1-5. https://doi.org/10.1080/03079450701772391
  8. Kapczynski, D. R. and D. J. King. 2005. Protection of chickens against overt clinical disease and determination of viral shedding following vaccination with commercially available Newcastle disease virus vaccines upon challenge with highly virulent virus from the California 2002 exotic Newcastle disease outbreak. Vaccine 23: 3424-3433. https://doi.org/10.1016/j.vaccine.2005.01.140
  9. van Oirschot, J. T. 1999. Diva vaccines that reduce virus transmission. J. Biotechnol. 73: 195-205. https://doi.org/10.1016/S0168-1656(99)00121-2
  10. Kaiser, P. 2010. Advances in avian immunology--prospects for disease control: a review. Avian. Pathol. 39: 309-324. https://doi.org/10.1080/03079457.2010.508777
  11. Akira, S. 2000. The role of IL-18 in innate immunity. Curr. Opin. Immunol. 12: 59-63. https://doi.org/10.1016/S0952-7915(99)00051-5
  12. Rahman, M. M., E. Uyangaa, Y. W. Han, S. B. Kim, J. H. Kim, J. Y. Choi, and S. K. Eo. 2012. Enhancement of Th1-biased protective immunity against avian influenza H9N2 virus via oral co-administration of attenuated Salmonella enterica serovar Typhimurium expressing chicken interferon-α and interleukin-18 along with an inactivated vaccine. BMC Vet. Res. 8: 105. https://doi.org/10.1186/1746-6148-8-105
  13. Rahman, M. M., E. Uyangaa, Y. W. Han, S. B. Kim, J. H. Kim, J. Y. Choi, and S. K. Eo. 2012. Oral co-administration of live attenuated Salmonella enterica serovar Typhimurium expressing chicken interferon-$\alpha$ and interleukin-18 enhances the alleviation of clinical signs caused by respiratory infection with avian influenza virus H9N2. Vet. Microbiol. 157: 448-455. https://doi.org/10.1016/j.vetmic.2011.12.029
  14. Hung, L. H., H. P. Li, Y. Y. Lien, M. L. Wu, and H. C. Chaung. 2010. Adjuvant effects of chicken interleukin-18 in avian Newcastle disease vaccine. Vaccine 28: 1148-1155. https://doi.org/10.1016/j.vaccine.2009.11.042
  15. Lim, K. L., S. D. Jazayeri, S. K. Yeap, N. B. Alitheen, M. H. Bejo, A. Ideris, and A. R. Omar. 2012. Co-administration of avian influenza virus H5 plasmid DNA with chicken IL-15 and IL-18 enhanced chickens immune responses. BMC Vet. Res. 8: 132. https://doi.org/10.1186/1746-6148-8-132
  16. Ding, A. H., C. F. Nathan, and D. J. Stuehr. 1988. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J. Immunol. 141: 2407-2412.
  17. Rahman, M. M., E. Uyangaa, Y. W. Han, S. B. Kim, J. H. Kim, J. Y. Choi, D. J. Yoo, J. T. Hong, S. B. Han, B. Kim, K. Kim, and S. K. Eo. 2011. Oral administration of live attenuated Salmonella enterica serovar Typhimurium expressing chicken interferon-α alleviates clinical signs caused by respiratory infection with avian influenza virus H9N2. Vet. Microbiol. 154: 140-151. https://doi.org/10.1016/j.vetmic.2011.06.034
  18. Pollock, K. G., M. Conacher, X. Q. Wei, J. Alexander, and J. M. Brewer. 2003. Interleukin-18 plays a role in both the alum-induced T helper 2 response and the T helper 1 response induced by alum-adsorbed interleukin-12. Immunology 108: 137-143. https://doi.org/10.1046/j.1365-2567.2003.01581.x
  19. Schneider, K., F. Puehler, D. Baeuerle, S. Elvers, P. Staeheli, B. Kaspers, and K. C. Weining. 2000. cDNA cloning of biologically active chicken interleukin-18. J. Interferon. Cytokine. Res. 20: 879-883. https://doi.org/10.1089/10799900050163244
  20. Göbel, T. W., K. Schneider, B. Schaerer, I. Mejri, F. Puehler, S. Weigend, P. Staeheli, and B. Kaspers. 2003. IL-18 stimulates the proliferation and IFN-gamma release of CD4+ T cells in the chicken: conservation of a Th1-like system in a nonmammalian species. J. Immunol. 171: 1809-1815. https://doi.org/10.4049/jimmunol.171.4.1809
  21. Degen, W. G., H. I. van Zuilekom, N. C. Scholtes, N. van Daal, and V. E. Schijns. 2005. Potentiation of humoral immune responses to vaccine antigens by recombinant chicken IL-18 (rChIL-18). Vaccine 23: 4212-4218. https://doi.org/10.1016/j.vaccine.2005.04.003
  22. Su, B. S., P. C. Shen, L. H. Hung, J. P. Huang, H. S. Yin, and L. H. Lee. 2011. Potentiation of cell-mediated immune responses against recombinant HN protein of Newcastle disease virus by recombinant chicken IL-18. Vet. Immunol. Immunopathol. 141: 283-292. https://doi.org/10.1016/j.vetimm.2011.03.018
  23. Kim, S. J., S. B. Kim, Y. W. Han, E. Uyangaa, J. H. Kim, J. Y. Choi, K. Kim, and S. K. Eo. 2012. Co-administration of live attenuated Salmonella enterica serovar Typhimurium expressing swine interleukin-18 and interferon-$\alpha$ provides enhanced Th1-biased protective immunity against inactivated vaccine of pseudorabies virus. Microbiol. Immunol. 56: 529-540 https://doi.org/10.1111/j.1348-0421.2012.00473.x
  24. Lee, B. M., Y. W. Han, S. B. Kim, M. M. Rahman, E. Uyangaa, J. H. Kim, Y. S. Roh, B. Kim, S. B. Han, J. T. Hong, K. Kim, and S. K. Eo. 2011. Enhanced protection against infection with transmissible gastroenteritis virus in piglets by oral co-administration of live attenuated Salmonella enterica serovar Typhimurium expressing swine interferon-$\alpha$ and interleukin-18. Comp. Immunol. Microbiol. Infect. Dis. 34: 369-380. https://doi.org/10.1016/j.cimid.2011.05.001
  25. Beal, R. K., C. Powers, T. F. Davison, P. A. Barrow, and A. L. Smith. 2006. Clearance of enteric Salmonella enterica serovar Typhimurium in chickens is independent of B-cell function. Infect. Immun. 74: 1442-1444. https://doi.org/10.1128/IAI.74.2.1442-1444.2006
  26. Beal, R. K., P. Wigley, C. Powers, S. D. Hulme, P. A. Barrow, and A. L. Smith. 2004. Age at primary infection with Salmonella enterica serovar Typhimurium in the chicken influences persistence of infection and subsequent immunity to re-challenge. Vet. Immunol. Immunopathol. 100: 151-164. https://doi.org/10.1016/j.vetimm.2004.04.005
  27. Steidler, L., S. Neirynck, N. Huyghebaert, V. Snoeck, A. Vermeire, B. Goddeeris, E. Cox, J. P. Remon, and E. Remaut. 2003. Biological containment of genetically modified Lactococcus lactis for intestinal delivery of human interleukin-10. Nat. Biotechnol. 21: 785-789. https://doi.org/10.1038/nbt840
  28. Rupa, P., V. Monedero, and B. N. Wilkie. 2008. Expression of bioactive porcine interferon-gamma by recombinant Lactococcus lactis. Vet. Microbiol. 129: 197-202. https://doi.org/10.1016/j.vetmic.2007.11.010

피인용 문헌

  1. Modulation of systemic and mucosal immunity against an inactivated vaccine of Newcastle disease virus by oral co-administration of live attenuated Salmonella enterica serovar Typhimurium expressing vol.77, pp.4, 2013, https://doi.org/10.1292/jvms.14-0495
  2. Initiation and regulation of immune responses to immunization with whole inactivated vaccines prepared from two genetically and antigenically distinct lineages of Egyptian influenza A virus subtype H5 vol.161, pp.10, 2016, https://doi.org/10.1007/s00705-016-2989-2
  3. THE IMMUNOSTIMULAN POTENTIAL OF TENGGULUN (PROTIUM JAVANICUM) LEAVES TOWARDS T CELL CD4+ AND IFNγ SECRETION ON PBMC CHICKEN vol.6, pp.3, 2017, https://doi.org/10.20473/ijtid.v6i3.2992