대한한의학회지 (The Journal of Korean Medicine)

  • 제34권4호
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  • Pages.1-11
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  • 2013
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  • 1010-0695(pISSN)
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  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
권호 표지
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Galgeun-tang, an Herbal Formula, Ameliorates Atopic Dermatitis Responses in Dust Mite Extract-treated NC/Nga Mice

  • Ha, Hyekyung (Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine) ;
  • Lee, Jun Kyoung (Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine) ;
  • Lee, Mee-Young (Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine) ;
  • Lim, Hye-Sun (Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine) ;
  • Shin, Hyeunkyoo (Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine)
  • 투고 : 2013.09.10
  • 심사 : 2013.11.28
  • 발행 : 2013.12.30
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초록

Objectives: Galgeun-tang (GGT, gegen-tang, kakkon-to), an herbal formula, is used to treat the common cold, fevers, headaches, hangovers and neck and upper back stiffness. The drugs currently used to treat atopic dermatitis (AD) are limited by the significant adverse effects associated with their long-term usage. The need to efficiently manage the AD response while reducing side effects has led to the development of alternative remedies. Methods: To assess the effects of GGT on AD, the anti-inflammatory and anti-AD properties of GGT were evaluated in both in vitro and in vivo systems. Results: Nitric oxide (NO) and histamine production on lipopolysaccharide (LPS)-treated RAW264.7 cells and phorbol-12 myristate 13-acetate (PMA)/A23187-treated MC/9 cells, respectively, were inhibited by GGT. GGT reduced thymus and activation-regulated chemokine (TARC/CCL17) release on TNF-${\alpha}$/IFN-${\gamma}$ stimulated HaCaT cells in a dose-dependent manner. GGT reduced both plasma levels of IgE and histamine and the dermatitis score in house dust mite induced atopic dermatitis-like lesions on NC/Nga mice. However, there were no significant histopathological differences observed between the GGT group and the AD-induced group, such as AD-like lesions in the dorsal skin or ear or mast cell infiltration in the dorsal skin. Conclusions: These results indicate that GGT inhibits chemokine production by keratinocytes and the atopic dermatitis response in NC/Nga mice, suggesting that GGT may be useful as a therapeutic remedy for treating AD and allergic inflammation-related diseases.

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참고문헌

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피인용 문헌

  1. Galgeun-tang Attenuates Cigarette Smoke and Lipopolysaccharide Induced Pulmonary Inflammation via IκBα/NF-κB Signaling vol.23, pp.10, 2013, https://doi.org/10.3390/molecules23102489
  2. 독성시험관리기준 적용 갈근탕의 안전성 평가 vol.27, pp.3, 2013, https://doi.org/10.7783/kjmcs.2019.27.3.173