Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
권호 표지
DOI QR코드

DOI QR Code

Prevalence of rotavirus genotypes in South Korea in 1989-2009: implications for a nationwide rotavirus vaccine program

  • Than, Van Thai (Department of Microbiology, Research Center for Medical Sciences, Chung-Ang University College of Medicine) ;
  • Kim, Wonyong (Department of Microbiology, Research Center for Medical Sciences, Chung-Ang University College of Medicine)
  • 투고 : 2013.04.23
  • 심사 : 2013.08.18
  • 발행 : 2013.11.15
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The epidemiology of human group A rotavirus was analyzed by examining genotypic data acquired from 1989 to 2009 in South Korea. This information was derived from all the available published articles on rotavirus studies in South Korea, retrieved from both the PubMed and KoreaMed databases. Four common G types (G1, G2, G3, and G4) and three common P types (P[8], P[4], and P[6]) accounted for approximately 93% and 99% of the rotavirus reports, respectively. The G9 type was frequently detected after 2000, and because of this prevalence, it is considered to be the fifth most important G type rotavirus after the G1-G4 genotypes. Less common G types of the virus such as G12, G11, and G10 were detected in some geographic settings, and it is important to consider the context of these subtypes and their epidemiological significance. The P[9] virus genotype was observed in the study and has been discussed in many other studies; however, the P[3], P[10] and P[25] genotypes were rarely detected in the epidemiological research. In general, the distributions of the G and P genotypes showed temporal and geographical fluctuations, and a nationwide rotavirus vaccine program that targeted these genotypes demonstrated effectiveness in protecting against the circulating rotavirus strains. However, further analysis is needed to determine the true long-term effectiveness of these vaccines; the analysis should also consider the unexpected effects of vaccinations, such as vaccineinduced diseases, herd immunity, and changes in host susceptibilities.

키워드

참고문헌

  1. Cortese MM, Parashar UD; Centers for Disease Control and Prevention (CDC). Prevention of rotavirus gastroenteritis among infants and children: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2009; 58(RR-2):1-25.
  2. Parashar UD, Burton A, Lanata C, Boschi-Pinto C, Shibuya K, Steele D, et al. Global mortality associated with rotavirus disease among children in 2004. J Infect Dis 2009;200 Suppl 1:S9-15. https://doi.org/10.1086/605025
  3. Patel MM, Steele D, Gentsch JR, Wecker J, Glass RI, Parashar UD. Real-world impact of rotavirus vaccination. Pediatr Infect Dis J 2011;30(1Suppl):S1-5. https://doi.org/10.1097/INF.0b013e3181fefa1f
  4. Matthijnssens J, Otto PH, Ciarlet M, Desselberger U, Van Ranst M, Johne R. VP6-sequence-based cutoff values as a criterion for rotavirus species demarcation. Arch Virol 2012;157:1177-82. https://doi.org/10.1007/s00705-012-1273-3
  5. Estes MK. Rotaviruses. In: Knipe DM, Howley PM, Griffin DE, Martin MA, editors. Fields virology. 5th ed. Philadelphia: Lippincott Williams & Wilkins, 2007;1917-74.
  6. Estes MK, Cohen J. Rotavirus gene structure and function. Microbiol Rev 1989;53:410-49.
  7. Bishop RF, Davidson GP, Holmes IH, Ruck BJ. Detection of a new virus by electron microscopy of faecal extracts from children with acute gastroenteritis. Lancet 1974;1:149-51.
  8. Hasegawa A, Matsuno S, Inouye S, Kono R, Tsurukubo Y, Mukoyama A, et al. Isolation of human rotaviruses in primary cultures of monkey kidney cells. J Clin Microbiol 1982;16:387-90.
  9. Yolken R, Wyatt RG, Kapikian AZ. ELISA for rotavirus. Lancet 1977;2:819.
  10. Haikala OJ, Kokkonen JO, Leinonen MK, Nurmi T, Mantyjarvi R, Sarkkinen HK. Rapid detection of rotavirus in stool by latex agglutination: comparison with radioimmunoassay and electron microscopy and clinical evaluation of the test. J Med Virol 1983; 11:91-7. https://doi.org/10.1002/jmv.1890110202
  11. Kalica AR, Sereno MM, Wyatt RG, Mebus CA, Chanock RM, Kapikian AZ. Comparison of human and animal rotavirus strains by gel electrophoresis of viral RNA. Virology 1978;87:247-55. https://doi.org/10.1016/0042-6822(78)90130-7
  12. Flores J, Boeggeman E, Purcell RH, Sereno M, Perez I, White L, et al. A dot hybridisation assay for detection of rotavirus. Lancet 1983;1:555-8.
  13. Wilde J, Yolken R, Willoughby R, Eiden J. Improved detection of rotavirus shedding by polymerase chain reaction. Lancet 1991;337:323-6. https://doi.org/10.1016/0140-6736(91)90945-L
  14. Seo JK, Sim JG. Overview of rotavirus infections in Korea. Pediatr Int 2000;42:406-10. https://doi.org/10.1046/j.1442-200x.2000.01250.x
  15. Kim KH, Suh IS, Kim JM, Kim CW, Cho YJ. Etiology of childhood diarrhea in Korea. J Clin Microbiol 1989;27:1192-6.
  16. Kim KH, Yang JM, Joo SI, Cho YG, Glass RI, Cho YJ. Importance of rotavirus and adenovirus types 40 and 41 in acute gastroenteritis in Korean children. J Clin Microbiol 1990;28:2279-84.
  17. Huh JW, Kim WH, Moon SG, Lee JB, Lim YH. Viral etiology and incidence associated with acute gastroenteritis in a 5-year survey in Gyeonggi province, South Korea. J Clin Virol 2009;44:152-6. https://doi.org/10.1016/j.jcv.2008.11.016
  18. Koh H, Baek SY, Shin JI, Chung KS, Jee YM. Coinfection of viral agents in Korean children with acute watery diarrhea. J Korean Med Sci 2008;23:937-40. https://doi.org/10.3346/jkms.2008.23.6.937
  19. Saitou N, Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol 1987;4:406-25.
  20. Felsenstein J. PHYLIP (Phylogeny inference package) version 3.5c Seattle: Department of Genetics, University of Washington, 1993.
  21. Jukes TH, Cantor CR. Evolution of protein molecules: mammalian protein metabolism. New York: Academic Press, 1969:21-132.
  22. Bass ES, Pappano DA, Humiston SG. Rotavirus. Pediatr Rev 2007; 28:183-91. https://doi.org/10.1542/pir.28-5-183
  23. Brandt CD, Kim HW, Rodriguez WJ, Thomas L, Yolken RH, Arrobio JO, et al. Comparison of direct electron microscopy, immune electron microscopy, and rotavirus enzyme-linked immunosorbent assay for detection of gastroenteritis viruses in children. J Clin Microbiol 1981;13:976-81.
  24. Flewett TH, Bryden AS, Davies H. Letter: virus particles in gastroenteritis. Lancet 1973;2:1497.
  25. Kapikian AZ, Dienstag JL, Purcell RH. Immune electron microscopy as a method for the detection, identification, and characterization of agents not cultivable in an in vitrosystem. In: Rose NR, Friedman H, editors. Manual of clinical immunology. Washington, DC: American Society for Microbiology, 1976:467-80.
  26. Birch CJ, Rodger SM, Marshall JA, Gust ID. Replication of human rotavirus in cell culture. J Med Virol 1983;11:241-50. https://doi.org/10.1002/jmv.1890110307
  27. Urasawa S, Urasawa T, Taniguchi K. Three human rotavirus serotypes demonstrated by plaque neutralization of isolated strains. Infect Immun 1982;38:781-4.
  28. Yolken RH, Kim HW, Clem T, Wyatt RG, Kalica AR, Chanock RM, et al. Enzyme-linked immunosorbent assay (ELISA) for detection of human reovirus-like agent of infantile gastroenteritis. Lancet 1977;2:263-7.
  29. Taniguchi K, Urasawa T, Morita Y, Greenberg HB, Urasawa S. Direct serotyping of human rotavirus in stools by an enzyme-linked immunosorbent assay using serotype 1-, 2-, 3-, and 4-specific monoclonal antibodies to VP7. J Infect Dis 1987;155:1159-66. https://doi.org/10.1093/infdis/155.6.1159
  30. Greenberg H, McAuliffe V, Valdesuso J, Wyatt R, Flores J, Kalica A, et al. Serological analysis of the subgroup protein of rotavirus, using monoclonal antibodies. Infect Immun 1983;39:91-9.
  31. Sanekata T, Yoshida Y, Okada H. Detection of rotavirus in faeces by latex agglutination. J Immunol Methods 1981;41:377-85. https://doi.org/10.1016/0022-1759(81)90199-X
  32. Espejo RT, Calderon E, Gonzalez N. Distinct reovirus-like agents associated with acute infantile gastroenteritis. J Clin Microbiol 1977;6:502-6.
  33. Matsui SM, Mackow ER, Matsuno S, Paul PS, Greenberg HB. Sequence analysis of gene 11 equivalents from "short" and "super short" strains of rotavirus. J Virol 1990;64:120-4.
  34. Fernandez J, Sandino A, Yudelevich A, Avendano LF, Venegas A, Hinrichsen V, et al. Rotavirus detection by dot blot hybridization assay using a non-radioactive synthetic oligodeoxynucleotide probe. Epidemiol Infect 1992;108:175-84. https://doi.org/10.1017/S0950268800049621
  35. Yamakawa K, Nakagomi O. Improved detection of rotavirus RNA in dot-blot hybridization assay by chromatographic extraction and acid denaturation of double-stranded RNA. Mol Cell Probes 1990;4:415-8. https://doi.org/10.1016/0890-8508(90)90032-U
  36. Buesa J, Colomina J, Raga J, Villanueva A, Prat J. Evaluation of reverse transcription and polymerase chain reaction (RT/PCR) for the detection of rotaviruses: applications of the assay. Res Virol 1996;147:353-61. https://doi.org/10.1016/S0923-2516(97)85127-8
  37. Bishop RF, Masendycz PJ, Bugg HC, Carlin JB, Barnes GL. Epidemiological patterns of rotaviruses causing severe gastroenteritis in young children throughout Australia from 1993 to 1996. J Clin Microbiol 2001;39:1085-91. https://doi.org/10.1128/JCM.39.3.1085-1091.2001
  38. Kang CM. Clinical, epidemiological, and serological observation on human rotavirus gastroenteritis in infants and children. J Korean Pediatr Soc 1985;28:140-6.
  39. Rhee EO, Hwang NJ, Choi YS, Seo SS. Clinical studies of human rotavirus gastroenteritis. J Korean Pediatr Soc 1989;32:1369-76.
  40. Kim H, Kim K, Kim J, Cho Y, Kim D, Choi T. Genomic diversity of human rotaviruses, a cause of diarrhea in Korean children: 1989- 1994. J Korean Soc Microbiol 1997;32:237-44.
  41. Shim SY, Jung YC, Le VP, Son DW, Ryoo E, Shim JO, et al. Genetic variation of G4P[6] rotaviruses: evidence for novel strains circulating between the hospital and community. J Med Virol 2010; 82:700-6. https://doi.org/10.1002/jmv.21698
  42. Le VP, Chung YC, Kim K, Chung SI, Lim I, Kim W. Genetic variation of prevalent G1P[8] human rotaviruses in South Korea. J Med Virol 2010;82:886-96. https://doi.org/10.1002/jmv.21653
  43. Min BS, Noh YJ, Shin JH, Baek SY, Kim JO, Min KI, et al. Surveillance study (2000 to 2001) of G- and P-type human rotaviruses circulating in South Korea. J Clin Microbiol 2004;42: 4297-9. https://doi.org/10.1128/JCM.42.9.4297-4299.2004
  44. Matthijnssens J, Ciarlet M, McDonald SM, Attoui H, Banyai K, Brister JR, et al. Uniformity of rotavirus strain nomenclature proposed by the Rotavirus Classification Working Group (RCWG). Arch Virol 2011;156:1397-413. https://doi.org/10.1007/s00705-011-1006-z
  45. Santos N, Hoshino Y. Global distribution of rotavirus serotypes/ genotypes and its implication for the development and implementation of an effective rotavirus vaccine. Rev Med Virol 2005; 15:29-56. https://doi.org/10.1002/rmv.448
  46. Song MO, Kim KJ, Chung SI, Lim I, Kang SY, An CN, et al. Distribution of human group a rotavirus VP7 and VP4 types circulating in Seoul, Korea between 1998 and 2000. J Med Virol 2003;70:324-8. https://doi.org/10.1002/jmv.10398
  47. Moon SS, Green YS, Song JW, Ahn CN, Kim H, Park KS, et al. Genetic distribution of group A human rotavirus types isolated in Gyunggi province of Korea, 1999-2002. J Clin Virol 2007;38:57-63. https://doi.org/10.1016/j.jcv.2006.10.004
  48. Le VP, Kim JY, Cho SL, Nam SW, Lim I, Lee HJ, et al. Detection of unusual rotavirus genotypes G8P[8] and G12P[6] in South Korea. J Med Virol 2008;80:175-82. https://doi.org/10.1002/jmv.21044
  49. Shim JO, Baek IH, Le VP, Ko EM, Seok WS, Uh Y, et al. Molecular characterization of rotavirus diarrhea among children in South Korea: detection of an unusual G11 strain. Arch Virol 2011;156: 887-92. https://doi.org/10.1007/s00705-010-0911-x
  50. Lee SY, Hong SK, Lee SG, Suh CI, Park SW, Lee JH, et al. Human rotavirus genotypes in hospitalized children, South Korea, April 2005 to March 2007. Vaccine 2009;27 Suppl 5:F97-101. https://doi.org/10.1016/j.vaccine.2009.09.002
  51. Park S, Oh S, Lee J, Park G, Choi S, Chae Y, et al. Genotypes of rotavirus associated with acute gastroenteritis in Seoul, Korea. Microbiol Immunol 2011;55:641-4. https://doi.org/10.1111/j.1348-0421.2011.00366.x
  52. Huh JW, Kim WH, Yoon MH, Lim YH. Genotypic distribution of rotavirus strains causing severe gastroenteritis in Gyeonggi province, South Korea, from 2003 to 2005. Arch Virol 2009;154: 167-70. https://doi.org/10.1007/s00705-008-0275-7
  53. Kang JO, Kilgore P, Kim JS, Nyambat B, Kim J, Suh HS, et al. Molecular epidemiological profile of rotavirus in South Korea, July 2002 through June 2003: emergence of G4P[6] and G9P[8] strains. J Infect Dis 2005;192 Suppl 1:S57-63. https://doi.org/10.1086/431502
  54. Han TH, Kim CH, Chung JY, Park SH, Hwang ES. Genetic characterization of rotavirus in children in South Korea from 2007 to 2009. Arch Virol 2010;155:1663-73. https://doi.org/10.1007/s00705-010-0752-7
  55. Jin Q, Ward RL, Knowlton DR, Gabbay YB, Linhares AC, Rappaport R, et al. Divergence of VP7 genes of G1 rotaviruses isolated from infants vaccinated with reassortant rhesus rotaviruses. Arch Virol 1996;141:2057-76. https://doi.org/10.1007/BF01718215
  56. Kim JS, Kang JO, Cho SC, Jang YT, Min SA, Park TH, et al. Epidemiological profile of rotavirus infection in the Republic of Korea: results from prospective surveillance in the Jeongeub District, 1 July 2002 through 30 June 2004. J Infect Dis 2005;192 Suppl 1:S49-56. https://doi.org/10.1086/431506
  57. Than VT, Kang H, Lim I, Kim W. Molecular characterization of serotype G9 rotaviruses circulating in South Korea between 2005 and 2010. J Med Virol 2013;85:171-8. https://doi.org/10.1002/jmv.23436
  58. Clark HF, Hoshino Y, Bell LM, Groff J, Hess G, Bachman P, et al. Rotavirus isolate WI61 representing a presumptive new human serotype. J Clin Microbiol 1987;25:1757-62.
  59. Kang JO, Kim CR, Kilgore PE, Choi TY. G and P genotyping of human rotavirus isolated in a university hospital in Korea: implications for nosocomial infections. J Korean Med Sci 2006; 21:983-8. https://doi.org/10.3346/jkms.2006.21.6.983
  60. Jeong HS, Lee KB, Jeong AY, Jo MY, Jung SY, Ahn JH, et al. Genotypes of the circulating rotavirus strains in the seven prevaccine seasons from September 2000 to August 2007 in South Korea. Clin Microbiol Infect 2011;17:232-5. https://doi.org/10.1111/j.1469-0691.2010.03232.x
  61. Than VT, Baek IH, Kim W. Whole genomic analysis reveals the coevolutionary phylodynamics of Korean G9P[8] human rotavirus strains. Arch Virol 2013;158:1795-803. https://doi.org/10.1007/s00705-013-1662-2
  62. Pietsch C, Liebert UG. Human infection with G12 rotaviruses, Germany. Emerg Infect Dis 2009;15:1512-5. https://doi.org/10.3201/eid1509.090497
  63. Le VP, Kim JB, Shon DH, Chung IS, Yoon Y, Kim K, et al. Molecular characterization of rare G12P[6] rotavirus isolates closely related to G12 strains from the United States, CAU 195 and CAU 214. Arch Virol 2011;156:511-6. https://doi.org/10.1007/s00705-010-0865-z
  64. Than VT, Le VP, Lim I, Kim W. Complete genomic characterization of cell culture adapted human G12P[6] rotaviruses isolated from South Korea. Virus Genes 2011;42:317-22. https://doi.org/10.1007/s11262-011-0576-x
  65. Hong SK, Lee SG, Lee SA, Kang JH, Lee JH, Kim JH, et al. Characterization of a G11,P[4] strain of human rotavirus isolated in South Korea. J Clin Microbiol 2007;45:3759-61. https://doi.org/10.1128/JCM.01505-07
  66. Kapikian AZ, Hoshino Y, Chanock RM. Rotaviruses. In: Knipe DM, Howley PM, Griffin DE, Martin MA. editors. Fields virology. 5th ed. Philadelphia: Lippincott Williams & Wilkins, 2007;1787-825.
  67. Taniguchi K, Nishikawa K, Urasawa T, Urasawa S, Midthun K, Kapikian AZ, et al. Complete nucleotide sequence of the gene encoding VP4 of a human rotavirus (strain K8) which has unique VP4 neutralization epitopes. J Virol 1989;63:4101-6.
  68. Rotavirus vaccines. WHO position paper - January 2013. Wkly Epidemiol Rec 2013;88:49-64.
  69. O'Ryan M, Linhares AC. Update on Rotarix: an oral human rotavirus vaccine. Expert Rev Vaccines 2009;8:1627-41. https://doi.org/10.1586/erv.09.136
  70. Araujo EC, Clemens SA, Oliveira CS, Justino MC, Rubio P, Gabbay YB, et al. Safety, immunogenicity, and protective efficacy of two doses of RIX4414 live attenuated human rotavirus vaccine in healthy infants. J Pediatr (Rio J) 2007;83:217-24.
  71. Vesikari T, Karvonen A, Prymula R, Schuster V, Tejedor JC, Cohen R, et al. Efficacy of human rotavirus vaccine against rotavirus gastroenteritis during the first 2 years of life in European infants: randomised, double-blind controlled study. Lancet 2007;370:1757-63. https://doi.org/10.1016/S0140-6736(07)61744-9
  72. Salem K, Bdour S, Zeller M, Van Ranst M, Matthijnssens J. Genotypes of rotavirus strains circulating in Amman, Jordan, in 2006/07 and their significance for the potential effectiveness of future rotavirus vaccination. Arch Virol 2011;156:1543-50. https://doi.org/10.1007/s00705-011-1028-6
  73. Kang HY, Kim KH, Kim JH, Kim HM, Kim J, Kim MS, et al. Economic evaluation of the national immunization program of rotavirus vaccination for children in Korea. Asia Pac J Public Health 2013;25:145-58. https://doi.org/10.1177/1010539511416806
  74. Kim JS, Bae CW, Lee KY, Park MS, Choi YY, Kim KN, et al. Immunogenicity, reactogenicity and safety of a human rotavirus vaccine (RIX4414) in Korean infants: a randomized, double-blind, placebo-controlled, phase IV study. Hum Vaccin Immunother 2012;8:806-12. https://doi.org/10.4161/hv.19853
  75. Kim DS, Lee TJ, Kang JH, Kim JH, Lee JH, Ma SH, et al. Immunogenicity and safety of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine in healthy infants in Korea. Pediatr Infect Dis J 2008;27:177-8.

피인용 문헌

  1. Whole-Genome Analysis of a Rare Human Korean G3P Rotavirus Strain Suggests a Complex Evolutionary Origin Potentially Involving Reassortment Events between Feline and Bovine Rotaviruses vol.9, pp.5, 2014, https://doi.org/10.1371/journal.pone.0097127
  2. 로타바이러스 백신 도입 후 로타바이러스 위장관염의 추이: 일개 3차 병원의 후향적 연구 vol.21, pp.3, 2014, https://doi.org/10.14776/kjpid.2014.21.3.167
  3. Characterization of RotaTeq® vaccine‐derived rotaviruses in South Korean infants with rotavirus gastroenteritis vol.87, pp.1, 2013, https://doi.org/10.1002/jmv.23975
  4. Changing patterns of rotavirus strains circulating in Ireland: Re‐emergence of G2P[4] and identification of novel genotypes in Ireland vol.87, pp.5, 2013, https://doi.org/10.1002/jmv.24095
  5. Changing distribution of age, clinical severity, and genotypes of rotavirus gastroenteritis in hospitalized children after the introduction of vaccination: a single center study in Seoul between 2011 vol.16, pp.None, 2016, https://doi.org/10.1186/s12879-016-1623-y
  6. Prevalence and genotypes of group A rotavirus among outpatient children under five years old with diarrhea in Beijing, China, 2011–2016 vol.18, pp.None, 2013, https://doi.org/10.1186/s12879-018-3411-3
  7. Emergence of G8P[6] rotavirus strains in Korean neonates vol.10, pp.None, 2013, https://doi.org/10.1186/s13099-018-0255-8
  8. Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events vol.8, pp.None, 2013, https://doi.org/10.1038/s41598-018-24511-y
  9. Whole-genome analysis of rotavirus G4P[6] strains isolated from Korean neonates: association of Korean neonates and rotavirus P[6] genotypes vol.11, pp.None, 2013, https://doi.org/10.1186/s13099-019-0318-5
  10. Clinical and Environmental Surveillance of Rotavirus Common Genotypes Showed High Prevalence of Common P Genotypes in Egypt vol.12, pp.2, 2020, https://doi.org/10.1007/s12560-020-09426-0
  11. Dynamics of G2P[4] strain evolution and rotavirus vaccination: A review of evidence for Rotarix vol.38, pp.35, 2013, https://doi.org/10.1016/j.vaccine.2020.06.059
  12. Relationship Between Rotavirus P[6] Infection in Korean Neonates and Histo-Blood Group Antigen: a Single-Center Study vol.41, pp.2, 2021, https://doi.org/10.3343/alm.2021.41.2.181
  13. Detection and evaluation of rotavirus surveillance methods as viral indicator in the aquatic environments vol.52, pp.2, 2021, https://doi.org/10.1007/s42770-020-00417-8