Asian Pacific Journal of Cancer Prevention

  • 제14권10호
  • /
  • Pages.5631-5635
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  • 2013
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Radiation-induced Cochlea Hair Cell Death: Mechanisms and Protection

  • Tan, Pei-Xin (Department of Radiation Oncology, Nanfang Hospital, Southern Medical University) ;
  • Du, Sha-Sha (Department of Radiation Oncology, Nanfang Hospital, Southern Medical University) ;
  • Ren, Chen (Department of Radiation Oncology, Nanfang Hospital, Southern Medical University) ;
  • Yao, Qi-Wei (Department of Radiation Oncology, Nanfang Hospital, Southern Medical University) ;
  • Yuan, Ya-Wei (Department of Radiation Oncology, Nanfang Hospital, Southern Medical University)
  • 발행 : 2013.10.30
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초록

Cochlea hair cell death is regarded to be responsible for the radiation-induced sensorineural hearing loss (SNHL), which is one of the principal complications of radiotherapy (RT) for head and neck cancers. In this mini-review, we focus on the current progresses trying to unravel mechanisms of radiation-induced hair cell death and find out possible protection. P53, reactive oxygen species (ROS) and c-Jun N-terminal kinase (JNK) pathways have been proposed as pivotal in the processes leading to radiation hair cell death. Potential protectants, such as amifostine, N-acetylcysteine (NAC) and epicatechin (EC), are claimed to be effective at reducing radiation-inducedhair cell death. The RT dosage, selection and application of concurrent chemotherapy should be pre-examined in order to minimize the damage to cochlea hair cells.

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