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Physical Inactivity, Water Intake and Constipation as Risk Factors for Colorectal Cancer among Adults in Jordan

  • 발행 : 2013.09.30

초록

Background: Physical activity has been found to play a role in cancer prevention. The purpose of this matched case-control study was to investigate the association between physical activity levels, water intake, constipation and colorectal cancer (CRC). Materials and Methods: Two hundred and thirty-two patients diagnosed with CRC (125 male, 107 female) were enrolled in this case-control study. Cases were matched to 271 population controls (137 male, 134 female). Results: Drinking more than 4 cups of water daily decreased the risk of CRC by 33-42%; however, this effect was non-significant. Having constipation was found to be a significant risk factor for developing CRC with an OR=6.284 (95%CI=2.741-14.40). With reference to sedentary behavior, minimum activity (600-3000 Metabolic Equivalents Task (MET)) had 43% protection against CRC and the level of Health Enhancing Physical Activity OR was 0.58 (at 95%CI; 0.37-0.92). A significant negative association was found between CRC and physical activity levels expressed as both METs and MET-hours/week (p for trend=0.017 and 0.03, respectively). Among females, a significant trend of reduction in CRC by 62% was observed with increasing the level of physical activity expressed in MET (p for trend=0.04). Conclusions: The risk of CRC may be reduced by adopting a healthy lifestyle and practicing physically activity regularly, especially among females. Consuming adequate amounts of water and healthy bowel motility could also reduce the risk of CRC.

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참고문헌

  1. Alharbi N, Alshammari M, Almutairi B, Makboul G, El-Shazly M (2012). Knowledge, awareness, and practices concerning breast cancer among Kuwaiti female school teachers. Alexandria J Med, 48, 75-82. https://doi.org/10.1016/j.ajme.2011.10.003
  2. Boutron-Ruault MC, Senesse P, Meance S, Belghiti C, Faivre J (2001). Energy intake, body mass index, physical activity, and the colorectal adenoma-carcinoma sequence. Nutr. Cancer, 39, 50-7. https://doi.org/10.1207/S15327914nc391_7
  3. Breslow R, Sorkin J, Frey C, Kessler L (1997). Americans' knowledge of cancer risk and survival. Prev Med, 26, 170-7. https://doi.org/10.1006/pmed.1996.0136
  4. Campbell P, Cotterchio M, Dicks E, et al (2007). Excess body weight and CRC risk in Canada: associations in subgroups of clinically defined familial risk of cancer. Cancer Epidemiol Biomarkers Prev, 16, 1735-44. https://doi.org/10.1158/1055-9965.EPI-06-1059
  5. Clinton SK, Bostwick DG, Olson LM, Mangian HJ, Visek WJ (1988). Effects of ammonium acetate arid sodium cholate on N-methyl-N0-nitro-N-nitrosocolon colon carcinogenesis of rats. Cancer Res, 48, 3035-9.
  6. Dobrila-Dintinjana R, Trivanovic D, Zelic M, et al (2012). Nutritional support in patients with CRC during chemotherapy: does it work? Hepatogastroenterology, 60, 475-80.
  7. Friedenreich C, Orenstein M (2002). Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr, 132, 3456-64. https://doi.org/10.1093/jn/132.11.3456S
  8. Fu Z, Shrubsole M, Smalley W, et al (2012). Lifestyle factors and their combined impact on the risk of colorectal polyps. Am J Epidemiol, 176, 766-76. https://doi.org/10.1093/aje/kws157
  9. Giovannucci E (1995). Insulin and colon cancer. Cancer Causes Control, 6, 164-79. https://doi.org/10.1007/BF00052777
  10. Iber FL, Parveen S, Vandrunen M, et al (1993). Relation of symptoms to impaired stomach, small bowel, and colon motility in long-standing diabetes. Dig Dis Sci, 38, 45-50. https://doi.org/10.1007/BF01296772
  11. Kotake K, Koyama Y, Nasu J, Fukutomi T, Yamaguchi N (1995). Relation of family history of cancer and environmental factors to the risk of CRC: a case-control study. Jpn J Clin Oncol, 25, 195-202.
  12. Kune GA, Kune S, Watson LF (1990). Body weight and physical activity as predictors of CRC risk. Nutr Cancer, 13, 9-17. https://doi.org/10.1080/01635589009514041
  13. Lee IM, Paffenbarger RS Jr, Hsieh C (1991). Physical activity and risk of developing CRC among college alumni. J Natl Cancer Inst, 83, 1324-9. https://doi.org/10.1093/jnci/83.18.1324
  14. Lee RD, Nieman DC (2010). Nutritional Assessment. 5th ed. New York: McGraw Hill.
  15. Marchand L, Wilkens L, Kolonel L, Hankin J, Lyu LC (1997). Associations of sedentary lifestyle, obesity, smoking, alcohol use, and diabetes with the risk of CRC. Cancer Research, 57, 4787-94.
  16. McKeown-Eyssen G (1994). Epidemiology of CRC revisited: are serum triglycerides and/or plasma glucose associated with risk? Cancer Epidemiol Biomarkers Prev, 3, 687-95.
  17. McTiernan A (2008). Mechanisms linking physical activity with cancer. Nat Rev Cancer, 8, 205-11. https://doi.org/10.1038/nrc2325
  18. Meyerhardt J, Giovannucci E, Holmes M, et al (2006). Physical activity and survival after CRC diagnosis. J Clin Oncol, 24, 3527-34. https://doi.org/10.1200/JCO.2006.06.0855
  19. Nakamura T, Imamura K, Kasai F, et al (1993). Fecal excretions of hydroxy fatty acid and bile acid in diabetic diarrheal patients. J Diabetes Complications, 7, 8-11. https://doi.org/10.1016/1056-8727(93)90017-S
  20. Narisawa T, Magadia NE, Weisburger JH, Wynder EL (1974). Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N'-nitro-Nnitrosoguanidine in rats. J Natl Cancer Inst, 53, 1093-7. https://doi.org/10.1093/jnci/53.4.1093
  21. Nilsen T, Vatten L (2001). Prospective study of CRC risk and physical activity, diabetes, blood glucose and BMI: exploring the hyperinsulinaemia hypothesis. Bri J Cancer, 84, 417-22. https://doi.org/10.1054/bjoc.2000.1582
  22. Peppone L, Hyland A, Moysich K, et al (2009). Examining the association between cigarette smoking and CRC using historical case-control data. Cancer Epidemiol, 33, 182-8. https://doi.org/10.1016/j.canep.2009.07.004
  23. Peters RK, Garabrant DH, Yu MC, Mack T (1989). A casecontrol study of occupational and dietary factors in CRC in young men by subsite. Cancer Res, 49, 5459-68.
  24. Reddy BS, Watanabe K, Weisburger JH, Wynder EL (1977). Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats. Cancer Res, 37, 3238-42.
  25. Roberts M, Millikan R, Galanko J, Martin C, Sandler R (2003). Constipation, laxative use, and colon cancer in a North carolina population. Am J Gastroenterol, 98, 857-64. https://doi.org/10.1111/j.1572-0241.2003.07386.x
  26. Sallis JF, Haskell WL, Wood PD (1985). Physical activity assessment methodology in the five-city project. Am J Epidemiol. 121, 91-106. https://doi.org/10.1093/oxfordjournals.aje.a113987
  27. Sanchez-Lara K, Ugalde-Morales E, Motola-Kuba D, Green D (2013). Gastrointestinal symptoms and weight loss in cancer patients receiving chemotherapy. Br J Nutr, 109, 894-7. https://doi.org/10.1017/S0007114512002073
  28. Shannon J, White E, Shattuck A L, Potter JD (1996). Relationship of food groups and water intake to colon cancer risk. Cancer Epidemiol Biomarkers Prev, 5, 495-502.
  29. Simons C, Hughes L, Engeland M, et al (2013). Physical activity, occupational sitting time, and CRC risk in the Netherlands cohort study. Am J Epidemiol, 177, 514-30. https://doi.org/10.1093/aje/kws280
  30. Slattery ML, Ballard-Barbash R, Edwards S, Caan BJ, Potter JD (2003). Body mass index and colon cancer: an evaluation of the modifying effects of estrogen (United States). Cancer Causes Control, 14, 75-84. https://doi.org/10.1023/A:1022545017867
  31. Slattery M L, Edwards S, Curtin K, et al (2003). Physical activity and CRC. Am J Epidemiol, 158, 214-24. https://doi.org/10.1093/aje/kwg134
  32. Steindorf K, Tobiasz-Adamczyk B, Popiela T, et al (2000). Combined risk assessment of physical activity and dietary habits on the development of CRC. A hospital-based casecontrol study in Poland. Eur J Cancer Prev, 9, 309-16. https://doi.org/10.1097/00008469-200010000-00004
  33. Stewart BW, Kleihues P (2003). World cancer report. Geneva, World Health Organization/Lyon, International Agency for Research on Cancer.
  34. Tang R, Wang J, LO S, Hsieh L (1999). Physical activity, water intake and risk of CRC in Taiwan: a hospital-based casecontrol study. Int J Cancer, 82, 484-9. https://doi.org/10.1002/(SICI)1097-0215(19990812)82:4<484::AID-IJC3>3.0.CO;2-A
  35. Thune I, Lund E (1996). Physical activity and risk of CRC in men and women. Bri J Cancer, 73, 1134-40. https://doi.org/10.1038/bjc.1996.218
  36. Ugajin H (1989). The role of bile acids with physiological concentration in colon carcinogenesis. Nippon Shoukakibyo Gakkai Zasshi, 86, 1627-37.
  37. Whittemore A, Wu-Williams A, Lee M, et al (1990). Diet, physical activity, and CRC among Chinese in North America and China. J Natl Cancer Inst, 82, 915-26. https://doi.org/10.1093/jnci/82.11.915
  38. Wolin K, Tuchman H (2011). Physical activity and gastrointestinal cancer prevention. Recent Results Cancer Res, 186, 73-100.
  39. Wu AH, Paganini-Hill A, Ross RK, Henderson BE (1987). Alcohol, physical activity and other risk factors for CRC: a prospective study. Bri J Cancer, 55, 687-94. https://doi.org/10.1038/bjc.1987.140
  40. Zarkovic M, Qin X, Nakatsuru Y, et al (1993). Tumor promotion by fecapentaene-12 in a rat colon carcinogenesis model. Carcinogenesis, 14, 1261-4. https://doi.org/10.1093/carcin/14.7.1261

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