Journal of the Korea Academia-Industrial cooperation Society (한국산학기술학회논문지)

The Korea Academia-Industrial cooperation Society (한국산학기술학회)
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Antioxidant Activity and Effects on Brain Tissues After Administering Kudzu Leaf Extract on Rats with Induced Stress Due to Laryngeal Injury

후두 손상으로 스트레스 유발시킨 랫드에 칡잎추출물을 투여 후 항산화작용과 뇌 조직에 미치는 영향

  • Received : 2013.08.21
  • Accepted : 2013.12.05
  • Published : 2013.12.31
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Abstract

To examine the effects of voice disorders after a laryngeal injuryon the changes in stress, this study examined the effects of the changes observed in laboratory animals and on stress reduction effects, by inducing a laryngeal injury in SD type rats after administering a kudzu leaf extract, which has a sedation effect. For testing, a total of 24 rats comprising the normal group, control group and experimental groups (1 and 2 6 rats in each group) were used, and antioxidant experiments and molecular and chemical tests were conducted by administering a specified amount of kudzu teaorally once a day at a set time, 6 times per week for 5 weeks. The control group appeared to be significantly higher than the normal group (p <0.05), whereas the experimental group showed significant decreases compared to the control group (p <0.05), showing a better result than the normal group. The test results showed that the kudzu leaf extract resulted in significant changes compared to the control group. Overall, the administration of kudzu leaf extract has stress reduction effects.

본 연구는 후두 손상 후 목소리 장애로 인해 스트레스변화에 미치는 영향을 알아보고자 SD계 랫드에 후두손상을 유발시킨 후 실험동물에서 나타나는 변화와 스트레스 경감효과에 미치는 영향을 진정작용이 있는 칡잎추출물을 투여 후 변화를 보고자 하였다. 실험은 정상군, 대조군, 실험군(1, 2)으로 하여 군당 6마리씩 총 24마리를 이용하였고, 지정된 용량으로 1일 1회 일정한 시간대에 주 6회씩 5주간 경구투여 후 항산화실험과 분자화학적 검사를 하였다. 결과는 정상군에 비하여 대조군에서는 통계적으로 유의성 있게 높았으며(p<0.05), 실험군에서는 대조군에 비해 통계적 유의성 있게 낮아져(p<0.05), 정상군보다도 좋게 나타났다. 실험결과를 종합해 보면 칡잎추출물은 대조군과 비교 할 때 통계적으로 유의성 있는 변화를 확인하였다. 따라서 칡잎추출물 투여 시 스트레스 경감효과에 효과가 있는 것으로 사료된다.

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