동아시아식생활학회지 (Journal of the East Asian Society of Dietary Life)

  • 제23권6호
  • /
  • Pages.713-722
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  • 2013
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  • 1225-6781(pISSN)
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  • 2288-8802(eISSN)
동아시아식생활학회 (The East Asian Society of Dietary Life)
권호 표지

녹차가루가 당뇨 쥐의 골 대사 지표 및 골밀도에 미치는 영향

Effects of Green Tea Powder on Bone Markers and Bone Mineral Density in STZ-Induced Diabetic Rats

  • 최미자 (계명대학교 식품영양학과) ;
  • 조현주 (세계사이버대학 약용건강식품학과)
  • Choi, Mi-Ja (Department of Food and Nutrition, Keimyung University) ;
  • Jo, Hyun-Ju (Dept. of Medicinal Food and Health, World Cyber College)
  • 투고 : 2013.11.26
  • 심사 : 2013.12.30
  • 발행 : 2013.12.31
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초록

The purpose of this study was to examine the effects of dietary green tea powder supplementation on bone metabolism in streptozotocin-induced diabetic rats. Thirty-two male Sprague-Dawley rats (body weight $210{\pm}3g$) were divided into two groups, diabetic and non-diabetic groups. Each group was randomly divided into two subgroups which were fed with the control and 1% green tea powder diets. The serum and urine concentrations of calcium and phosphorus were determined. Serum osteocalcin and ALP and urinary DPD crosslinks value were measured in order to monitor bone formation and resorption. Bone mineral density (BMD) and bone mineral content (BMC) were estimated using PIXImus in the spine and femur. Body weight gain and FER were lower in the diabetic group than in the non-diabetic group regardless of diets. The serum concentration of calcium and phosphorus were not changed among all groups. Urinary calcium and phosphorus excretion were higher in the diabetic group than in the non-diabetic group regardless of diets; however, they were not significantly different by green tea powder intake. Serum alkaline phosphatase (ALP) was increased in the diabetic group than in thenon-diabetic group. Further, there were no significant differences in serum osteocalcin and urinary deoxypyridinoline crosslinks value among all groups. The levels of spine and femur bone mineral density of the diabetic group were significantly lower than that of the non-diabetic group. Within the diabetic group, spine BMD was significantly higher in rats fed with the green tea powder diet than in rats fed the control diet. Therefore, this study suggests that green tea powder has a beneficial effect on bone health, although it is not directly applicable to humans.

키워드

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