Genomics & Informatics

  • 제11권4호
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  • Pages.180-185
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  • 2013
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  • 1598-866X(pISSN)
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  • 2234-0742(eISSN)
한국유전체학회 (Korea Genome Organization)
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Genomic Profiling of Liver Cancer

  • Lee, Ju-Seog (Department of Systems Biology, The University of Texas MD Anderson Cancer Center)
  • 투고 : 2013.10.23
  • 심사 : 2013.11.21
  • 발행 : 2013.12.31
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초록

Development of liver cancers is driven largely by genomic alterations that deregulate signaling pathways, influencing growth and survival of cancer cells. Because of the hundreds or thousands of genomic/epigenomic alterations that have accumulated in the cancer genome, it is very challenging to find and test candidate genes driving tumor development and progression. Systematic studies of the liver cancer genome have become available in recent years. These studies have uncovered new potential driver genes, including those not previously known to be involved in the development of liver cancer. Novel approaches combining multiple datasets from patient tissues have created an unparalleled opportunity to uncover potential new therapeutic targets and prognostic/predictive biomarkers for personalized therapy that can improve clinical outcomes of the patients with liver cancer.

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참고문헌

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피인용 문헌

  1. Relatively Small Contribution of Methylation and Genomic Copy Number Aberration to the Aberrant Expression of Inflammation-Related Genes in HBV-Related Hepatocellular Carcinoma vol.10, pp.5, 2015, https://doi.org/10.1371/journal.pone.0126836
  2. Integrative transcriptome analysis of liver cancer profiles identifies upstream regulators and clinical significance of ACSM3 gene expression vol.40, pp.3, 2017, https://doi.org/10.1007/s13402-017-0321-0