Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Cardiopulmonary and Oxidative Stress Effects of Lung Lobectomy in Dogs; Comparison of Open and Thoracoscopic Surgery

개에서 폐엽절제가 심폐기능 및 산화 스트레스 상태에 미치는 영향; 일반개흉 및 흉강경을 통한 폐엽절제술 비교

  • Lee, Jae Yeon (Department of Veterinary Surgery, College of Veterinary Medicine.Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Myung Cheol (Department of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University)
  • 이재연 (충북대학교 수의과대학.동물의학연구소) ;
  • 김명철 (충남대학교 수의과대학)
  • Accepted : 2013.12.09
  • Published : 2013.12.31
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Abstract

In the present study, we investigated and compared the cardiopulmonary and oxidative stress effects of dogs undergoing open and thoracoscopic lung lobectomy. Ten healthy dogs, 5-8 years old, weighing 9-12 kg were used. The animals were randomly assigned to one of two groups according to the type of surgical procedure; open (group 1, n=5) or thoracoscopic lung lobectomy (group 2, n=5). Cardiopulmonary parameters, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) concentrations were measured. There were statistically significant changes in arterial blood gases values in both groups. Total anesthesia and surgical times were significantly shorter in thoracoscopic lobectomy group compared with open surgery group. Increases in plasma SOD and CAT levels, and decreases in GPx levels were observed in both groups after surgery. Significant difference in GPx levels was found when the groups were compared. The GPx level was significantly lower in the thoracoscopic lobectomy group compared with the open surgery group.

본 연구에서는 개에서 일반 개흉술을 통한 폐엽절제술과 흉강경을 이용한 폐엽절제술에서 심폐기능 및 생체 내 산화스트레스 상태에 미치는 영향을 비교 연구 하였다. 10 마리의 건강한 혼혈종을 사용하였고 일반 개흉술을 통한 폐엽절제술군 (group 1, n=5)과 흉강경을 이용한 폐엽절제술군 (group 2, n=5)으로 분류하였다. 심혈관계 측정 항목 및 superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx)의 농도를 측정하였다. 두 군에서 동맥혈액 가스의 유의적인 변화를 관찰 할 수 있었다. 총 마취 및 수술 시간은 개흉수술군에 비해 흉강경 폐엽 절제술군에서 유의하게 짧았다. 혈장 SOD와 CAT 수준의 증가, 그리고 GPX 수준의 감소는 수술 후 두 군 모두에서 관찰되었다. 두 군을 비교했을 때 GPX 수준에서 유의한 차이가 발견되었다. GPX 수준은 개흉 수술 군과 비교 흉강경 폐엽 절제술 군에서 유의하게 낮았다.

Keywords

References

  1. Borenstein N, Behr L, Chetboul V, Tessier D, Nicole A, Jacquet J, Carlos C, Retortillo J, Fayolle P, Pouchelon JL, Daniel P, Laborde F. Minimally invasive patent ductus arteriosus occlusion in 5 dogs. Vet Surg 2004; 33: 309-313. https://doi.org/10.1111/j.1532-950X.2004.04045.x
  2. Dupre GP, Corlouer JP, Bouvy B. Thoracoscopic pericardectomy performed without pulmonary exclusion in 9 dogs. Vet Surg 2001; 30: 21-27. https://doi.org/10.1053/jvet.2001.20344
  3. Hazelrigg SR, Landreneau RJ, Boley TM, Priesmeyer M, Schmaltz RA, Nawarawong W, Johnson JA, Walls JT, Curtis JJ. The effect of muscle-sparing versus standard posterolateral thoracotomy on pulmonary function, muscle strength, and postoperative pain. J Thorac Cardiovasc Surg 1991; 101: 394-401.
  4. Isakow K, Fowler D, Walsh P. Video-assisted thoracoscopic division of the ligamentum arteriosum in two dogs with persistent right aortic arch. J Am Vet Med Assoc 2000; 217: 1333-1337. https://doi.org/10.2460/javma.2000.217.1333
  5. Koksal H, Kurban S. Total oxidant status, total antioxidant status, and paraoxonase and arylesterase activities during laparoscopic cholecystectomy. Clinics 2010; 65: 285-290. https://doi.org/10.1590/S1807-59322010000300008
  6. Landreneau RJ, Hazelrigg SR, Mack MJ, Dowling RD, Burke D, Gavlick J, Perrino MK, Ritter PS, Bowers CM, DeFino J. Postoperative pain-related morbidity: Video-assisted thoracic surgery versus thoracotomy. Ann Thorac Surg 1993; 56: 1285-1289. https://doi.org/10.1016/0003-4975(93)90667-7
  7. Lansdowne JL, Monnet E, Twedt DC, Dernell WS. Thoracoscopic lung lobectomy for treatment of lung tumors in dogs. Vet Surg 2005; 34: 530-535. https://doi.org/10.1111/j.1532-950X.2005.00080.x
  8. Lin J, Iannettoni MD. The role of thoracoscopy in the management of lung cancer. Surg Oncol 2003; 12: 195-200. https://doi.org/10.1016/S0960-7404(03)00029-X
  9. MacPhail CM, Monnet E, Twedt DC. Thoracoscopic correction of persistent right aortic arch in a dog. J Am Anim Hosp Assoc 2001; 37: 577-581. https://doi.org/10.5326/15473317-37-6-577
  10. Michels C, Raes M, Toussaint O, Remacle J. Importance of Se-glutathione peroxidase, catalase, and Cu/Zn SOD for cell survival against oxidative stress. Free Radic Biol Med 1994; 17: 235-248. https://doi.org/10.1016/0891-5849(94)90079-5
  11. Radlinsky MG, Mason DE, Biller DS, Biller DS, Olsen D. Thoracoscopic visualization and ligation of the thoracic duct in dogs. Vet Surg 2002; 31: 138-146. https://doi.org/10.1053/jvet.2002.31062
  12. Roviaro G, Varoli F, Vergani C, Maciocco M. State of the art in thoracoscopic surgery. Surg Endoscopy 2002; 16: 881-892. https://doi.org/10.1007/s00464-001-8153-3
  13. Roviaro G, Varoli F, Vergani C, Nucca O, Maciocco M, Grignani F. Long-term survival after videothoracoscopic lobectomy for stage I lung cancer. Chest 2004; 126: 725-732. https://doi.org/10.1378/chest.126.3.725
  14. Sies, H. Oxidative stress: oxidants and antioxidants. Exp Physiol 1997; 82: 291-295. https://doi.org/10.1113/expphysiol.1997.sp004024
  15. Stipancic I, Zarkovic N, Servis D, Sabolovic S, Tatzber F, Busic Z. Oxidative stress markers after laparoscopic and open cholecystectomy. J Laparoendosc Adv Surg Tech A 2005; 15: 347-352. https://doi.org/10.1089/lap.2005.15.347
  16. Stobie D, Caywood DD, Rozanski EA, Bing DR, Dhokarikar P, Raffe MR, Kannan MS, King VL, Hegstad RL, Randall DA. Evaluation of pulmonary function and analgesia in dogs after intercostals thoracotomy and use of morphine administered intramuscularly or intrapleurally and bupivacaine administered intrapleurally. Am J Vet Res 1995; 56: 1098-1109.
  17. Swanson SJ, Batirel HF. Video-assisted thoracic surgery (VATS) resection for lung cancer. Surg Clin North Am 2002; 82: 541-559. https://doi.org/10.1016/S0039-6109(02)00015-4
  18. Thompson SE, Johnson JM. Analgesia in dogs after intercostals thoracotomy: a comparison of morphine, selective intercostals nerve block, and interpleural regional analgesia with bupivacaine. Vet Surg 1991; 20: 73-77. https://doi.org/10.1111/j.1532-950X.1991.tb00309.x
  19. Walsh PJ, Remedios AM, Ferguson JF, Walker DD, Cantwell S, Duke T. Thoracoscopic versus open partial pericardectomy in dogs: comparison of postoperative pain and morbidity. Vet Surg 1999; 28: 472-479. https://doi.org/10.1111/j.1532-950X.1999.00472.x