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A Case of Acute Leukoencephalopathy Patient with Akinetic Mutism and Cognitive Dysfunctions

무동무언증과 인지기능장애를 주소로 하는 급성 백질뇌증 환자 치험 1례

  • Kim, Bo-Eun (Department of Oriental Neuropsychiatry, College of Oreintal Medicine, Daegu Hanny University) ;
  • Chung, Dae-Kyoo (Department of Oriental Neuropsychiatry, College of Oreintal Medicine, Daegu Hanny University) ;
  • Kim, Sang-Ho (Department of Oriental Neuropsychiatry, College of Oreintal Medicine, Daegu Hanny University) ;
  • Lee, Kyung-Suk (Department of Oriental Neuropsychiatry, College of Oreintal Medicine, Daegu Hanny University)
  • 김보은 (대구한의대학교 한의과대학 신경정신과교실) ;
  • 정대규 (대구한의대학교 한의과대학 신경정신과교실) ;
  • 김상호 (대구한의대학교 한의과대학 신경정신과교실) ;
  • 이경석 (대구한의대학교 한의과대학 신경정신과교실)
  • Received : 2013.11.12
  • Accepted : 2013.12.16
  • Published : 2013.12.30

Abstract

This case report presents a 34-year-old female patient. Her chief complaints are akinetic mutism and cognitive dysfunctions. We have diagnosed her with leukoencephalopathy. She was treated with Korean traditional herbal medicines (Joojackwhan) for 33 days continuously. The effects of treatment were measured by the Korean Mini - Mental State Examination and Modified Bathel Index. After treatment, her chief complaints have been improved. Furthermore, the K-MMSE, MBI scores increased. From this case, we deduced that the Korean traditional herbal medicines (Joojackwhan) could be effective for cognitive dysfunctions and akinetic mutism caused by leukoencephalopathy.

Keywords

References

  1. Wheatley CJ. Occupational Theraphy Practice Skills of Physical Dysfunction. St. Louis: Mosby; 2001;456-64.
  2. Mateer CA. Cognitive Neurorehabilitaion. Cambridge: Cambridge University Press; 1999;314-32.
  3. Michael JA, Robert BD. Encyclopeia of the Neurological Sciences. Boston: Academic Press; 2003.
  4. Bakheit AMO, Fletcher K, Brennan A. Successful Treatment of Severe Abulia with Co-beneldopa. NeuroRehabilitation. 2011;29:347-51.
  5. Jug SW, Rhee KH, Lee JE, Kwon YS, Kim SK, Son BK. Acute Leukoencephalopathy during Cyclosporin A Therapy in a Pediatric Patient with Nephrotic Syndrome. J Korean Soc Pediatr Nephrol. 2005;9(1):91-6.
  6. Jin ST. Seokshilbirok. Seoul: Seowon-Dang; 1984.
  7. Jeon GH. Bianzhenggimun. Taipei: Gandhi Publisher; 1990.
  8. The Textbook Compilation Commitee of Neuropsychiatry of Oriental Medical Shools in Nation. The Neuropsychiatry of Oriental Medicine. Seoul: Jipmoon-Dang; 2011.
  9. Lee C. Introduction to Medicine. Seoul: Bubin Publisher; 2009;1892.
  10. Yamanaka K, Fukuyama H, Kimura J. Abulia from Unilateral Capsular Genu Infarction: Report of Two Cases. Journal of the Neurological Sciences. 1996;143:181-4. https://doi.org/10.1016/S0022-510X(96)00201-8
  11. Alexander MP. Chronicc Akinetic Mutism after Mesencephalicdiencephalicinfarction: Remediated with Dopaminetgic Medications. NeurorehabilNeural Repair. 2001;15:151-6. https://doi.org/10.1177/154596830101500208
  12. American Congress of Rehabilitation Medicine. Recommendations for Use of Uniform Nomenclature Pertinent to Patients with Severe Alterations in Consciousness. Arch Phys Med Rehabil. 1995;76:205-9. https://doi.org/10.1016/S0003-9993(95)80031-X
  13. Ure J, Facio E, Videla H, Caccuri R, Giudice F, Ollari J, Diez M. Akinetic Mutism: A Report of Three Cases. Acta Neurol Scand. 1998;98:439-44. https://doi.org/10.1111/j.1600-0404.1998.tb07327.x
  14. Textbook Compilation Commitee of Herbology of Oriental Medical Shools in Nation. Herbology. Seoul: Younglim-Sa; 2005.
  15. The Compilation Commitee of Encyclopedia of Chinse Herbal Medicine. Encyclopedia of Chinse Herbal Medicine. Seoul: Jungdam; 1998.
  16. Hugel HM, Jackson N, May BH, Xue CC. Chinese Herbs for Dementia Diseases. Mini Rev Med Chem. 2012;12:371-9. https://doi.org/10.2174/138955712800493951
  17. Lin Z, Gu J, Xiu J, Mi T, Dong J, Tiwari JK. Traditional Chinese Medicine for Senile Dementia. Evid Based Complement Alternat Med. 2012;2012:692621.
  18. Cai M, Shin BY, Kim DH, et al. Neuroprotective Effects of a Traditional Herbal Prescription on Transient Cerebral Global Ischemia in Gerbils. J Ethnopharmacol. 2011;138:723-30. https://doi.org/10.1016/j.jep.2011.10.016
  19. Shi J, Tian JZ, Zhu AH, et al. The Influence of CGE on Expression of IL-1beta and c-fos Protein in the Hippocampus Region in Rats Following Cerebral ischemia-reperfusion. Zhongguo Zhong Yao Za Zhi. 2004;29:570-5.
  20. Zhang G, Liu A, Zhou Y, San X, Jin T, Jin Y. Panax Ginseng Ginsenoside-Rg2 Protects Memory Impairment via Anti-apoptosis in a Rat Model with Vascular Dementia. J Ethnopharmacol. 2008;115:441-8. https://doi.org/10.1016/j.jep.2007.10.026
  21. Lee MS, Yang EJ, Kim JI, Ernst E. Ginseng for Cognitive Function in Alzheimer's Disease: A Systematic Review. J Alzheimers Dis. 2009;18:339-44.
  22. Kim BE. Cognition and Motor Function Recovery Effects of Joojakwhan, A Traditional Korean Polyherbal Drug on the Mild Rat Stroke, Transient Middle Cerebral Artery Occlusion Dissertation. Kyunsan: Daegu Haany University; 2013.
  23. Kim EJ, Lee DW. A Case of Akinetic Mutism is Revealed during Contraction of Catatonc Schizophrena. J of Oriental Neuropsychiatry. 2001;12(1):193-200.