Journal of agriculture & life science (농업생명과학연구)

Institute of Agriculture & Life Science, Gyeongsang National University (경상대학교 농업생명과학연구원)
권호 표지

Phenolics of Propolis and in vitro Protective Effects against Oxidative Stress Induced Cytotoxicity

  • Jeong, Chang-Ho (Wooyang Frozen Food Co., Ltd.) ;
  • Jeong, Hee-Rok (Dept. of Food Science & Technology(Insti. of Agric. & Life Sci.), Gyeongsang National Univ.) ;
  • Kim, Dae-Ok (Dept. of Food Science & Biotechnology(Insti. of Life Sci. and Resources), Kyung Hee Univ.) ;
  • Choi, Sung-Gil (Dept. of Food Science & Technology(Insti. of Agric. & Life Sci.), Gyeongsang National Univ.) ;
  • Shim, Ki-Hwan (Dept. of Food Science & Technology(Insti. of Agric. & Life Sci.), Gyeongsang National Univ.) ;
  • Heo, Ho Jin (Dept. of Food Science & Technology(Insti. of Agric. & Life Sci.), Gyeongsang National Univ., Division of Applied & Life Sci.(BK21), Gyeongsang National Univ.)
  • Received : 2012.02.10
  • Accepted : 2012.06.26
  • Published : 2012.06.30
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Abstract

Anti-neurodegenerative activities of aqueous extract from propolis were investigated. The aqueous extracts showed strong antioxidant activities in malondialdehyde (MDA) assay, and it effectively inhibited lipid peroxidation. In addition, the aqueous extract presented protective effects against $H_2O_2-induced$ neurotoxicity in a dose-dependent manner. Our study verified that the aqueous extract has strong antioxidant activity and neuronal cell protective effect which is correlated with its total phenolics (290.75 mg GAE/g) including p-coumaric acid, vanillic acid and gallic acid. These phenolics of propolis may reduce the risk of neurodegenerative disorders, and can be utilized as effective and safe resources of functional food.

Keywords

Acknowledgement

Supported by : National Research Foundation

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