Korean Journal of Plant Resources (한국자원식물학회지)

The Plant Resources Society of Korea (한국자원식물학회)
권호 표지
DOI QR코드

DOI QR Code

Simultaneous Quantitative Determination of Flavone Glycosides in Youngia japonica by High-performance Liquid Chromatography

HPLC에 의한 뽀리뱅이 플라본 배당체 화합물의 동시정량

  • Nugroho, Agung (Department of Applied Plant Sciences, Graduate School, Sangji University) ;
  • Park, Hee-Juhn (Department of Pharmaceutical Engineering, Sangji University)
  • Received : 2012.08.18
  • Accepted : 2012.10.29
  • Published : 2012.10.29
Download PDF
⟨ Previous Next ⟩

Abstract

This research was attempted to determine the composition of flavone glycosides (luteolin 7-O-glucoside, luteolin 7-O-glucuronide, linarin) in addition to luteolin simultaneously in aerial part of Youngia japonica (Compositae) by high-performance liquid chromatography. The MeOH extract was further fractionated into the three parts, $CHCl_3$ fraction, EtOAc fraction and BuOH fraction, to investigate the contents of the four flavones in the three fractions. The content of luteolin 7-O-glucuronide (10.07 mg/g) was highest in the MeOH extract among those of the flavones. These four compounds were observed to be less than 1.0 mg/g in $CHCl_3$- and EtOAc fractions but relatively high in BuOH fraction.

Keywords

References

  1. Bowles, D., J. Isayenkova, E.K. Lim and B. Proppenberger. 2005. Glycosyltransferases: managers of small molecules. Cur. Opin. Plant Biol. 8:254-263. https://doi.org/10.1016/j.pbi.2005.03.007
  2. Bredebach, M., U. Matern and S. Martens. 2011. Three 2-oxoglutarate-dependent dioxygenase activities of Equisetum arvense L. forming flavone and flavonol from (2S)-naringenin. Phytochemistry 72:557-563. https://doi.org/10.1016/j.phytochem.2011.01.036
  3. Chen, W., Q. Liu, J. Wang, J. Zou, D. Meng, J. Zuo, X. Zhu and W. Zhao. 2006. New guaiane, megastigmane and eudesmanetype sesquiterpenoids and anti-inflammatory constituents from Youngia japonica. Planta Med. 72:143-50. https://doi.org/10.1055/s-2005-916182
  4. Curir, P., V. Lanzotti, M. Dolci, P. Dolci, C. Pasini and G. Tollin. 2003. Purification and properties of a new S-adenosyl- L-methionine: flavonoid 4'-O-methyltransferase from carnation (Dianthus caryophyllus L.). Eur. J. Biochem. 270:3422-3431. https://doi.org/10.1046/j.1432-1033.2003.03729.x
  5. Gulluce, M., M. Karadayi, Z. Guvenalp, H. Ozbek, T. Arasoglu and O. Baris. 2010. Isolation of some active compounds from Origanum vulgare L. ssp. Vulgare and determination of their genotoxic potentials. Food Chem. 130:248-253 (2010).
  6. Jang, D.S., T.J. Ha, S.U. Choi, S.G. Nam, K.H. Park, and M.S. Yang. Isolation of isoamberboin and isolipidiol from whole plants of Youngia japonica (L.) DC. 2000. Kor. J. Pharmacogn. 31:306-309.
  7. Kim, H.M., J.M. Lee, K.H. Lee, Y.H. Ahn, and S. Lee. 2011. Aldose reductase inhibition by luteolin derivatives from Parasenecio pseudotaimingasa. Nat. Prod. Sci. 17:367-371.
  8. Kim, M.R., M.R. Cha, Y.H. Choi, C.W. Choi, S.U. Choi, Y.S. Kim, Y.K. Kim, Y.H. Kim and S.Y. Ryu. 2010. Sesquiterpene glycosides from the whole plant extract of Youngia japonica. Kor. J. Pharmacogn. 41:103-107.
  9. Kim, T.J. 1996. Korean Resources Plants, Publishing Department of Seoul National University, Seoul, Korea. pp. 321-323.
  10. Lee, W.B., H.C. Kwon, J.H. Yi, S.U. Choi and K.R. Lee. 2002. A new cytotoxic triterpene hydroperoxide from the aerial part of Youngia japonica. Yakhak Hoeji 46:1-5.
  11. Min, Y.S., K.L. Bai, S.H. Yim, Y.J. Lee, H.J. Song, J.H. Kim, I.H. Ham, W.K. Whang and U.D. Sohn. 2006. The effect of luteolin 7-O-$\beta$-D-glucuronopyranoside on gastritis and esophagitis in rats. Arch. Pharm. Res. 29:484-489. https://doi.org/10.1007/BF02969421
  12. Nagy, M., Z., Krizkova, F. Sersen and J. Krajcovic. 2009. Antimutagenic activity and radical scavenging activity of water infusions and phenolics from ligustrum plants leaves. Molecules 14:509-518. https://doi.org/10.3390/molecules14010509
  13. Nazaruk, J. and J. Gudej. 2003. Flavonoid compounds from the flowers of Cirsium rivulare. Acta Pol. Pharm. 60:87-89.
  14. Ooi, L.S., Wang, H., He, Z. and Ooi, V.E. 2006. Antiviral activities of purified compounds from Youngia japonica (L.) DC (Asteraceae, Compositae). J. Ethnopharmacol. 106:187-91. https://doi.org/10.1016/j.jep.2005.12.028
  15. Park, H.J. 2010. Chemistry and pharmacological action of caffeoylquinic acid derivatives and pharmaceutical utilization of chwinamul (Korean Mountainous vegetable). Arch. Pharm. Res. 33:1703-1720. https://doi.org/10.1007/s12272-010-1101-9
  16. Shin, K.H., S.S. Kang, E.A. Seo and S.W. Shin. 1995. Isolation of aldose reductase inhibitors from the flowers of Chrysanthemum boreale. Arch. Pharm. Res. 18:65-68. https://doi.org/10.1007/BF02979135
  17. Vilela, F.C., M. Padilha-Mde, G. Alves-da-Silva, R. Soncini and A. Giusti-Paiva. 2010. Antidepressant-like activity of Sonchus oleraceus in mouse models of immobility tests. J. Med. Food 13:219-222. https://doi.org/10.1089/jmf.2008.0303
  18. Yae, E., S. Yahara, M. El-Asasr, T. Ikeda, H. Yoshimitsu, C. Masuoka, M. Ono, I. Hide, Y. Nakata, T. Nohara. 2009. Studies on the constituents of whole plants of Youngia japonica. Chem. Pharm. Bull. 57:719-723. https://doi.org/10.1248/cpb.57.719