Journal of Environmental Health Sciences (한국환경보건학회지)

Korean Society of Environmental Health (한국환경보건학회)
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Pallidal Signal Intensities on T1-weighted MRI are Highly Observed in Advanced Liver Cirrhosis

  • Weon, Young-Cheol (Department of Radiology, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Park, Neung-Hwa (Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Kim, Yang-Ho (Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Lee, Heun (Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine)
  • Received : 2012.06.19
  • Accepted : 2012.09.10
  • Published : 2012.10.31
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Abstract

Background: Manganese (Mn) has been found to increase the signal intensity of the globus pallidus (GP) on T1-weighted magnetic resonance images (MRI). We performed this study in order to determine the features of liver disease that correlate with pallidal signal intensities. Methods: We assessed blood Mn levels and pallidal signals in T1-weighted MRI in 49 patients with liver cirrhosis and 23 healthy controls. Results: Increased signal intensity in the GP was observed in 30 of 49 (61.2%) patients with liver cirrhosis, with the pallidal index (PI) in patients with Child-Pugh classes B and C differing significantly from the PI in controls. Multiple linear regression analysis showed that blood Mn concentrations and Child-Pugh scores in cirrhotics were significantly associated with increased PI after controlling for other confounders (p<0.05 each). Conclusions: Pallidal signals on T1-weighted MRI are mainly observed in advanced liver cirrhosis. The present study suggests that advanced liver cirrhosis may be a human model for manganism.

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References

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