The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지

Histological and Serological anti-Obesity Effect of Mori Folium in Obesity Induced SD Rat by High Fat Diet

상엽(桑葉)의 고지방식이 유도 비만 쥐에 대한 조직학적 및 혈청학적 항비만 효과 연구

  • Lee, Jee-Sook (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Noh, Hyun-In (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Yoon, Da-Rae (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Yi, Seo-Ra (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Lew, Jae-Hwan (East-west medicine department, Graduate school of east-west medical science, Kyung-Hee University)
  • 이지숙 (경희대학교 한의과대학 내과학교실) ;
  • 노현인 (경희대학교 한의과대학 내과학교실) ;
  • 윤다래 (경희대학교 한의과대학 내과학교실) ;
  • 이서라 (경희대학교 한의과대학 내과학교실) ;
  • 류재환 (동서의학대학원 동서의학과)
  • Published : 2012.09.30
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Abstract

Objectives : Mori Folium is used for hyperlipidemia or diabetes. The study was designed to test the anti-obesity effect of Mori Folium on body weight, hepatic fat accumulation and serum lipid level. Methods : The extract from Mori Folium was made by the pharmacy department of Kyung-hee oriental medical hospital. Normal diet, high-fat diet, 30% reduced diet and Mori Folium groups were set. The normal group was administered normal rat food, but the other three groups were administered high fat food. We measured body weight once a week. After 3 weeks experiment, hepatic lipid accumulations were measured. Also we compared serum lipid levels among the 4 groups after 3 weeks. Results : Mori Folium had no effect on body weight, but the 30% reduced diet had an inhibitory effect on body weight gain. Mori Folium had more inhibitory effect on hepatic fat accumulation than a 30% reduced diet. Mori Folium also has more inhibitory effect on serum triglyceride than 30% reduced diet. Conclusions : Mori Folium has anti-obesity effect on hepatic lipid accumulaion and serum triglyceride level in high fat diet induced rats.

Keywords

References

  1. The Korean Academy of Oriental Rehabilitation Medicine. Oriental Rehabilitation Medicine. Seoul: Koonja; 2005, p. 384-396.
  2. 박선민, 안일성, 김다솔, 강선아, 권대영, 양혜정. 고지방식이로 비만을 유도한 암컷 백서에서 태음조위탕과 도담탕의 항비만 효과 및 기전. J Appl Biol Chem 2010;53(1):44-50. https://doi.org/10.3839/jabc.2010.008
  3. 강금지, 임숙자, 정종길, 한혜경, 최성숙, 김명화, 등. 고지방식이를 섭취시킨 흰쥐에서 동과가 체중, 중성지방, Leptin과 지방세포의 크기에 미치는 영향. 한국영양학회지 2003;36(5):446-451.
  4. 김경오, 박상훈, 박철희, 한태호, 유교상, 김종혁, 등. 비알콜성 지방간에서 간조직 손상과 혈중 렙틴의 연관성. 대한간학회지 2005;11(1):51-58.
  5. Misra A, Pandey RM, Devi JR, Sharma R, Vikram NK, Khanna N. High prevalence of diabetes, obesity and dyslipidemia in urban slum population of northern India. Int J Obes Relat Metab Disord 2002;26(9):1281. https://doi.org/10.1038/sj.ijo.0802030
  6. 楊維傑. 黃帝內經靈樞解釋. 서울: 성보사; 1980, p. 304, 416.
  7. Yeo JJ, Hyng CL, Yang CS, Jeong SI, Seo ES, Jang IS. Effects of Mahuang for Weight Loss in Healthy Adults : A Double-Blind, Controlled, Randomized, Clinical Trial. Journal of Korean Oriental Medicine 2007;28(1):63-71.
  8. Youn DH. Effects of herbal acupuncture at Pungnyung and Umnumgchon in obese Rats induced by high fat diet. Journal of Korean Institute of Herbal Acupuncture 2004;7(1):87-100.
  9. Park JM, Kim HJ, Kim JA, Kim SJ, Ko BP. Effect of Ephedra sinica and Evodia Rutaecarpa on Resting Metabolic Rate in Obese Premenopausal Women during Low-calorie Diet : A Randomized Controlled Clinical Trial. Journal of Korean Oriental Association for Study of Obesity 2004; 4(1):45-54.
  10. Cho K, Seo B, Lee E, Park J. The effects of Artemisiae Iwayomogi Herba on rats fed high fat diet. Korean Journal of Herbology 2003; 18(3):57-67.
  11. Cho JH, Song BJ, Jang YJ. Effect of Taeyeumjowee-Tang and Electroacupuncture Combined-therapy on. Journal of Korean Oriental Association for Study of Obesity 2001;1(1): 1-11.
  12. Shin MS, Choi JB. The Effects of Choweseungchentang and Choweseungchengtanggamypang on the Change of Weight and Serum in Mice Fed High Fat Diet. J Oriental Rehab Med 2002;12(1):157-166.
  13. Kim KS, Kim SM. Effect of Chegamuiyiin-tang and Electro-lipolysis Acupuncture on the Reduction of Body Fat. Journal of Korean Oriental Association for Study of Obesity 2002;2(1):3-24.
  14. Bae JH, Jung SH, Lee JS, Kim SS, Shin HD. Clinical Study on the Efficacy of Yanghae in the Treatment of obesity. J Oriental Rehab Med 2003;13(1):37-46.
  15. Hwang MJ, Song MY, Shin HD. Literature Review of Herbal Medicines on Treatment of Obesity Since 2000;Mainly about Ephedra Herba. Journal of Korean Oriental Association for Study of Obesity 2007;7(1):39-54.
  16. 조미란, 조여원, 정성현, 류재환. 인슐린 비의존 형(Type II) 당뇨환자에서 누에분말 섭취가 혈당 및 혈중지질농도에 미치는 영향. 한국영양학회지 1998;31(7):1139-1150.
  17. 조영숙, 손미예, 이미경. 고지방식이를 급여한 C57BL/6 마우스에서 뽕잎분말과 열수추출물의 지질저하 작용. 한국식품영양과학회지 2007; 36(4):405-410.
  18. Medicine Education Training Institute. Family Practice. Seoul: Publishing department of Seoul University; 2003, p. 1011.
  19. Ministry of Health and Welfare. Medical Examination Research. 2005 Korean National Health Examination Nutrition Survey. 2006, p. 38-44.
  20. 정승희, 이경태, 안홍식, 이진용, 최종원, 김덕곤. 비만유도 흰쥐에 대한 방풍통성산가미방의 항고지혈 효과 및 항산화 효과. 생약학회지 2006;37(3):190-195.
  21. 신홍중, 윤일지. 비만1호방이 고지방식이로 비만 유도된 백서에 미치는 영향. 대한한의학회지 2008;29(2):116-132.
  22. 김종국, 오민석, 송태원. 비만의 약물치료에 관한 동서의학적 고찰. 대전대학교 한의학연구소 논문집 2002;11(1):193-199.
  23. 楊維傑. 黃帝內經素問解釋. 서울: 성보사; 1980, p. 253.
  24. 許浚. 東醫寶鑑. 서울: 남사당; 1992, p. 477.
  25. 이우열, 임병묵, 오민석. 麻黃複合方2號가 고지 방사료 식이로 유발된 비만 생쥐의 혈액 및 조직학적 변화에 미치는 영향. Korean Journal of Oriental Medicine 2006;12(1):77-88.
  26. Tak YJ, Lee YS, Kang JH. The Trend of Obesity-related Researches in Korea: from 1984 to 2002. Journal of Korean Oriental Association for Study of Obesity 2004;13(1): 1-13.
  27. 황재필, 윤일지. 減肥 4號方이 비만이 유도된 생쥐에 미치는 영향. 대한한의학회지 2010;31(1): 30-46.
  28. 김복순, 조여원, 신현대. 절식요법으로 인한 체중감소가 체조성과 혈청지질 및 뇨중 무기질 배설에 미치는 영향. 대한비만학회지 1996;5(1): 49-60.
  29. 양정화, 한지숙. 상엽추출물이 제2형 당뇨병 환자의 혈당, 당화혈색소 및 혈청지질에 미치는 영향. 한국식품영양과학회지 2006;35(5):549-556.
  30. Yshikumi Y. Inhibition of intestinal ${\alpha}$-glycosidase activity and postpranidal hyperglycemia by moranoline and its N-alkyl derivaties. Agric Biol Chem 1996;52:121-126.
  31. Andallu B, Varadacharyulu NCH. Antioxidant role of mulberry leaves in streptozotocin-diabetic rats. Clin Chim Acta 2003;338:3-10. https://doi.org/10.1016/S0009-8981(03)00322-X
  32. 이은, 김완재, 이영주, 이미경, 김판구, 박연정, 등. 지방간 환자를 위한 생식용 천연복합식품이 고지방식이를 급여한 흰쥐의 혈청, 간장의 효소 및 간조직 구조에 미치는 영향. 한국식품영양과학회지 2003;32(2):256-262.
  33. National statistical office, Republic of Korea. Annual report on the cause of the death statistics base on vital registration. 1997.