Animal cells and systems

The Korean Society for Integrative Biology (한국통합생물학회)
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Calcium and bioenergetics: from endoplasmic reticulum to mitochondria

  • Lee, Duk-Gyu (Department of Biochemistry, University of Alberta) ;
  • Michalak, Marek (Department of Biochemistry, University of Alberta)
  • Received : 2012.02.15
  • Accepted : 2012.04.09
  • Published : 2012.08.31
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Abstract

Controlling metabolism throughout life is a necessity for living creatures, and perturbation of energy balance elicits disorders such as type-2 diabetes mellitus and cardiovascular disease. $Ca^{2+}$ plays a key role in regulating energy generation. $Ca^{2+}$ homeostasis of the endoplasmic reticulum (ER) lumen is maintained through the action of $Ca^{2+}$ channels and the $Ca^{2+}$ ATPase pump. Once released from the ER, $Ca^{2+}$ is taken up by mitochondria where it facilitates energy metabolism. Mitochondrial $Ca^{2+}$ serves as a key metabolic regulator and determinant of cell fate, necrosis, and/or apoptosis. Here, we focus on $Ca^{2+}$ transport from the ER to mitochondria, and $Ca^{2+}$-dependent regulation of mitochondrial energy metabolism.

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References

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