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Physiochemical analysis, toxicity test and anti-bacterial effect of practically detoxified sulfur

법제유황의 실용적 제조에 따른 물리 화학적 분석 및 독성, 항균 작용에 관한 연구

  • In, Dong-Chul (College of Veterinary Medicine, Chonbuk National University) ;
  • Yu, Do-Hyeon (College of Veterinary Medicine, Chonbuk National University) ;
  • Park, Chul (College of Veterinary Medicine, Chonbuk National University) ;
  • Park, Jin-Ho (College of Veterinary Medicine, Chonbuk National University)
  • 인동철 (전북대학교 수의과대학) ;
  • 유도현 (전북대학교 수의과대학) ;
  • 박철 (전북대학교 수의과대학) ;
  • 박진호 (전북대학교 수의과대학)
  • Received : 2012.05.11
  • Accepted : 2012.08.29
  • Published : 2012.09.30

Abstract

Despite of a long history of the sulfur on the disease healing effect, there were limited ways of applying sulfur to animal and human. We have developed the detoxified sulfur (non toxic sulfur) method to make it practical and mass production possible through laboring for many years. This study practiced scanning electron microscope (SEM), Energy dispersive X-ray spectrometer (EDS) and secondary ion mass spectrometry (SIMS) analysis to investigate the physicochemical aspect of detoxified sulfur. We also performed the oral toxicity experiment to mice, and anti-bacterial test of the detoxified sulfur. Based on the SEM, EDS and SIMS results, the united particles in the mass form with the similar component intensity with the raw sulfur were observed, and hydrogen sulfide ion (HS-) component which is regarded as a toxic matter, was decreased after detoxification. Indeed, toxicity test on the mice (10 males, 10 females) showed no clinical, histopathological changes with the 5 times amount (2,500 mg/kg) of the actual doses. However, the male-mice showed decreased in body weight by 23.6%, 24.3% in the 7th, 14th day, respectively, after detoxified sulfur. Moreover, the female-mice administered the detoxified sulfur showed decreased in body weight by 28.7% (P<0.05) than that in the control group on the 14th day. The result of antibacterial test on the detoxified sulfur showed antibacterial effect (27%) to inhibit the growth of Staphylococcus aureus. It is shown that detoxified sulfur can be used as feed additive and has an affect on the farm perfomance.

Keywords

References

  1. 허준. 1991. 동의보감. pp. 1219. 학력개발사, 서울.
  2. Blake JP, Hess JB. 2001. Sodium bisulfate (PLT) as a litter treatment. Alabama Cooperative Extension System (Alabama A&M University and Auburn University). ANR-1208. http://www.aces.edu/pubs/docs/A/ANR-1208/ANR-1208.pdf.
  3. Fortina R, Barbera S, Lussiana C, Mimosi A, Tassone S, Rossi A, Zanardi E. 2005. Performances and meat quality of two Italian pig breeds fed diets for commercial hybrids. Meat Sci 71: 713-718. https://doi.org/10.1016/j.meatsci.2005.05.016
  4. Grimble RF, Grimble GK. 1998. Immunonutrition: role of sulfur amino acids, related amino acids, and polyamines. Nutrition 14: 605-610. https://doi.org/10.1016/S0899-9007(98)80041-5
  5. Guadagnini G. 1953. Sulfur therapy in chronic articular diseases. Reumatismo 5: 233-235.
  6. Gupta AK, Nicol K. 2004. The use of sulfur in dermatology. J Drugs Dermatol 3: 427-431.
  7. Lee JI, Min HK, Lee JW, Jeong JD, Ha YJ, Kwack SC, Park JS. 2009. Changes in the quality of loin from pigs supplemented with dietary methyl sulfonyl methane during cold storage. Korean J Food Sci Ani Resour 29: 229-237. https://doi.org/10.5851/kosfa.2009.29.2.229
  8. Libenson L, Hadley FP, McIlroy AP, Wetzel VM, Mellon RR. 1953. Antibacterial effect of elemental sulfur. J Infect Dis 93: 28-35. https://doi.org/10.1093/infdis/93.1.28
  9. Park JH, Ryu MS, Lee YE, Song GS, Ryu KS. 2003. A comparison of fattening performance, physico-chemical properties of breast meat, vaccine titers in cross bred meat type hybrid chicks fed sulfur. Korean J Poult Sci 30: 211-217.
  10. Weld JT, Gunther A. 1947. The antibacterial properties of sulfur. J Exp Med 85: 531-542. https://doi.org/10.1084/jem.85.5.531

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