생물정신의학 (Korean Journal of Biological Psychiatry)

  • 제19권2호
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  • Pages.77-83
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  • 2012
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  • 1225-8709(pISSN)
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  • 2005-7571(eISSN)
대한생물정신의학회 (The Korean Society of Biological Psychiatry)
권호 표지

정상 성인에서 남녀의 소뇌 구조 차이

Sex Differences in Cerebellar Structure of Healthy Adults

  • 김지현 (대구가톨릭대학병원 정신건강의학과) ;
  • 배수진 (서울대학교 자연과학대학 뇌과학협동과정) ;
  • 류근택 (이화여자대학교 의과대학 의학전문대학원 영상의학과학교실) ;
  • 강민성 (이화여자대학교 의과대학 의학전문대학원 영상의학과학교실) ;
  • 임수미 (이화여자대학교 의과대학 의학전문대학원 영상의학과학교실) ;
  • 이선호 (서울대학교 자연과학대학 뇌과학협동과정) ;
  • 이소진 (경상대학교 의학전문대학원 정신건강의학교실) ;
  • 고은 (서울대학교 인문대학 인지과학협동과정) ;
  • 정도언 (서울대학교 의과대학 정신건강의학교실)
  • Kim, Ji-Hyun H. (Department of Psychiatry, Daegu Catholic University Medical Center) ;
  • Bae, Su-Jin (Interdisciplinary Program in Neuroscience, Seoul National University College of Natural Sciences) ;
  • Ryu, Keun-Taik (Department of Radiology and Medical Research Institute, Ewha Womans University School of Medicine) ;
  • Kang, Min-Seong (Department of Radiology and Medical Research Institute, Ewha Womans University School of Medicine) ;
  • Lim, Soo-Mee (Department of Radiology and Medical Research Institute, Ewha Womans University School of Medicine) ;
  • Lee, Sun-Ho (Interdisciplinary Program in Neuroscience, Seoul National University College of Natural Sciences) ;
  • Lee, So-Jin (Department of Psychiatry, Gyeongsang National University School of Medicine) ;
  • Ko, Eun (Interdisciplinary Program in Cognitive Science, Seoul National University College of Humanities) ;
  • Jeong, Do-Un (Department of Psychiatry, Seoul National University College of Medicine)
  • 투고 : 2012.01.06
  • 심사 : 2012.01.20
  • 발행 : 2012.05.31
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초록

Objectives : Although there have been studies that examine sex differences of the brain structures using magnetic resonance imaging, studies that specifically investigate cerebellar structural differences between men and women are scarce. The purpose of current study was to examine sex differences in structures of the cerebellum using cerebellar template and cerebellum analysis methods. Methods : Sixteen men and twenty women were included in the study. A MATLAB based program (MathWorks, Natick, MA, USA), Statistical Parametric Mapping 5 (SPM5) using the spatially unbiased infra-tentorial atlas template (SUIT) as the cerebellum template, was used to analyze the brain imaging data. Results : There was no significant difference in age between men (mean age=28.1) and women (mean age=27.2). Men showed higher gray matter density than women in two left cerebellar areas including the clusters in the lobules IV and V (a cluster located across the lobules IV and V), and the lobule VIIIb (lobules IV and V, t=4.75, p<0.001 ; lobule VIIIb, t=3.08, p=0.004). Conclusions : The current study found differences in cerebellar gray matter density between men and women. The current study holds its significance for applying the template specifically developed for the analysis of cerebellum.

키워드

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