Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Association Analyses of ST8SIA2 Genetic Polymorphisms with Schizophrenia in the Korean Population

한국인 조현병 환자에서 ST8SIA2 유전자 다형성의 연합 연구

  • Yoo, Jae-Hyun (Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center) ;
  • Ryu, Seung-Hyong (Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center) ;
  • Cho, Eun-Young (Samsung Biomedical Research Institute, Center for Clinical Medicine) ;
  • Huh, Ik-Soo (Department of Statistics, College of Natural Science, Seoul National University) ;
  • Park, Tae-Sung (Department of Statistics, College of Natural Science, Seoul National University) ;
  • Lee, Yu-Sang (Yong-In Mental Hospital) ;
  • Kwon, Jun-Soo (Department of Psychiatry, Seoul National University College of Medicine, Seoul National University Hospital) ;
  • Hong, Kyung-Sue (Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center)
  • 유재현 (성균관대학교 의과대학 삼성서울병원 정신건강의학교실) ;
  • 류승형 (성균관대학교 의과대학 삼성서울병원 정신건강의학교실) ;
  • 조은영 (삼성생명과학연구소 임상의학연구센터) ;
  • 허익수 (서울대학교 자연과학대학 통계학과) ;
  • 박태성 (서울대학교 자연과학대학 통계학과) ;
  • 이유상 (용인정신병원) ;
  • 권준수 (서울대학교 의과대학 서울대학교병원 정신건강의학교실) ;
  • 홍경수 (성균관대학교 의과대학 삼성서울병원 정신건강의학교실)
  • Received : 2012.06.19
  • Accepted : 2012.07.17
  • Published : 2012.08.31
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Abstract

Objectives : ST8SIA2 (ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sialyltransferase 2 gene) is located at 15q26, a susceptibility locus for schizophrenia. Some previous research had indicated that single-nucleotide polymorphisms (SNPs) in the promoter region of ST8SIA2 were associated with schizophrenia in Japanese and Chinese populations. We investigated the association between SNPs in the promoter region of ST8SIA2 and schizophrenia in the Korean population. Methods : The study subjects were 190 Korean patients with schizophrenia and 190 healthy controls. We performed allelic, genotypic, and haplotypic association analyses for rs3759916, rs3759915 and rs3759914 of ST8SIA2. All genotypes were determined by direct sequencing. Results : In the genotype-based analysis, rs3759914 showed a nominally significant association with schizophrenia under recessive genotypic model (p = 0.047). However, this association did not remain statistically significant after correction for multiple testing. Both allelic and haplotype analyses did not show any significant association. Conclusions : These findings suggest that ST8SIA2 does not play a major role in the susceptibility to schizophrenia in the Korean population. Further studies with a larger number of subjects are required to definitively rule out minor effects of this gene on schizophrenia vulnerability.

Keywords

References

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