Journal of Sensor Science and Technology (센서학회지)

The Korean Sensors Society (한국센서학회)
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Easy Detection of Amyloid β-Protein Using Photo-Sensitive Field Effect

  • Kim, Kwan-Soo (IT Convergence Services Core Research Team, Electronics and Telecommunications Research Institute) ;
  • Ju, Jong-Il (Intelligent BioMEMS Lab., College of Health Science, Korea University) ;
  • Song, Ki-Bong (IT Convergence Services Core Research Team, Electronics and Telecommunications Research Institute)
  • Received : 2012.07.12
  • Accepted : 2012.09.17
  • Published : 2012.09.30
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Abstract

This article describes a novel method for the detection of amyloid-${\beta}$($A{\beta}$) peptide that utilizes a photo-sensitive field-effect transistor (p-FET). According to a recent study, $A{\beta}$ protein has been known to play a central role in the pathogenesis of Alzheimer's disease (AD). Accordingly, we investigated the variation of photo current generated from p-FET with and without intracellular magnetic beads conjugated with $A{\beta}$ peptides, which are placed on the p-FET sensing areas. The decrease of photo current was observed due to the presence of the magnetic beads on the channel region. Moreover, a similar characteristic was shown when the Raw 264 cells take in magnetic beads treated with $A{\beta}$ peptide. This means that it is possible to simply detect a certain protein using magnetic beads and a p-FET device. Therefore, in this paper, we suggest that our method could detect tiny amounts of $A{\beta}$ for early diagnosis of AD using the p-FET devices.

Keywords

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