The Korean Journal of Mycology (한국균학회지)

The Korean Society of Mycology (한국균학회)
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Biological Activities of Water Extract and Solvent Fractions of an Edible Mushroom, Hericium erinaceus

노루궁뎅이버섯 물 추출물 및 유기용매 분획물의 생리활성 효과

  • Kim, Jun-Ho (Department of Fine Chemistry and New Materials, Sangji University)
  • 김준호 (상지대학교 이공과대학 정밀화학신소재학과)
  • Received : 2012.08.16
  • Accepted : 2012.09.08
  • Published : 2012.09.28
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Abstract

This study was performed to investigate the biological activities of Hericium erinaceus fruiting body, including antioxidative, fibrinolytic, thrombin inhibitory and ${\alpha}$-glucosidase inhibitory activities. The water extract of H. erinaceus was fractionated into hexane, chloroform, ethyl acetate, butanol and water fractions, and each of these fractions was individually assayed. The water extract showed high antioxidative activity at 87.78%. The water fraction showed the highest extraction yield at 35.68% (w/w). In the fraction activity tests, butanol and water fractions showed strong antioxidative activities at 87.91% and 92.27%, respectively. Assays for fibrinolytic activity indicated that only the ethyl acetate fraction has significant efficacy at 2.96 plasmin units/mL. The 10-fold dilution of hexane fraction showed high thrombin inhibitory activity, and ${\alpha}$-glucosidase inhibitory activity at 77.67% and 90.53%, respectively. In conclusion, solvent fractions of H. erinaceus can be used as materials for the development of biofunctional foods to prevent cardiovascular diseases.

노루궁뎅이버섯을 이용하여 성인병 치료와 예방을 위한 기능성식품 개발을 위한 기초자료를 얻기 위해 노루궁뎅이버섯 물 추출물과 유기용매 분획물을 이용하여 성인병관련 생리활성을 확인하였다. 노루궁뎅이버섯 물 추출물은 87.78%의 항산화활성을 나타냈으며, 부탄올 분획물과물 분획물은 87.91%와 92.27%의 높은 활성을 나타냈다. 에틸 아세테이트 분획물은 2.96 plasmin unit의 높은 혈전용해 활성을 보였다. 핵산 분획물로부터 77.67%와 90.53%의 높은 트롬빈 저해활성과 ${\alpha}$-glucosidase 저해활성을 확인하였다. 실험 결과로부터 노루궁뎅이버섯 에틸아세테이트 분획물의 높은 혈전용해 활성과 핵산 분획물의 높은 트롬빈 저해활성과 ${\alpha}$-glucosidase 저해활성은 혈관계질환 치료나 예방을 위한 기능성식품 개발에 이용 가능할 것으로 기대된다.

Keywords

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