Environmental Analysis Health and Toxicology

  • 제27권
  • /
  • Pages.14.1-14.6
  • /
  • 2012
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  • 2671-9525(eISSN)
환경독성보건학회 (The Korean Society of Environmental Health and Toxicology)
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Lack of Mutagenicity Potential of Periploca sepium Bge. in Bacterial Reverse Mutation (Ames) Test, Chromosomal Aberration and Micronucleus Test in Mice

  • Zhang, Mei-Shu (Biotoxtech. Co. Ltd.) ;
  • Bang, In-Seok (Department of Biological Science and the Research Institute for Basic Sciences, Hoseo University) ;
  • Park, Cheol-Beom (Fusion Research Laboratory, Hoseo University)
  • 투고 : 2012.01.13
  • 심사 : 2012.06.08
  • 발행 : 2012.01.01
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초록

Objectives: The root barks of Periploca sepium Bge. (P. sepium) has been used in traditional Chinese medicine for healing wounds and treating rheumatoid arthritis. However, toxicity in high-doses was often diagnosed by the presence of many glycosides. The potential mutagenicity of P. sepium was investigated both in vitro and in vivo. Methods: This was examined by the bacterial reverse mutation (Ames) test using Escherichia coli WP2uvrA and Salmonella typhimurium strains, such as TA98, TA100, TA1535, and TA1537. Chromosomal aberrations were investigated using Chinese hamster lung cells, and the micronucleus test using mice. Results: P. sepium did not induce mutagenicity in the bacterial test or chromosomal aberrations in Chinese hamster lung cells, although metabolic activation and micronucleated polychromatic erythrocytes were seen in the mice bone marrow cells. Conclusions: Considering these results, it is suggested that P. sepium does not have mutagenic potential under the conditions examined in each study.

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참고문헌

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피인용 문헌

  1. Comparative Proteomic Analysis of the Effect of Periplocoside P from Periploca sepium on Brush Border Membrane Vesicles in Midgut Epithelium of Mythimna separata Larvae vol.10, pp.1, 2018, https://doi.org/10.3390/toxins10010007
  2. Antimicrobial agents of 4-methoxysalicylaldehyde isolated from Periploca sepium oil against foodborne bacteria: structure-activity relationship vol.61, pp.4, 2012, https://doi.org/10.1007/s13765-018-0373-5
  3. An LC-MS/MS Method for Simultaneous Determination of the Toxic and Active Components of Cortex Periplocae in Rat Plasma and Application to a Pharmacokinetic Study vol.2019, pp.None, 2012, https://doi.org/10.1155/2019/1639619
  4. Anti-nociceptive, anti-inflammatory and anti-arthritic activities of pregnane glycosides from the root bark of Periploca sepium Bunge vol.265, pp.None, 2021, https://doi.org/10.1016/j.jep.2020.113345