A Case of Primary Small Cell Carcinoma of the Supraglottis

성문상부에 발생한 원발성소세포암 1예

  • Lee, Su-Hyun (Department of Internal Medicine, College of Medicine, ST. Vincent's Hospital, The Catholic University of Korea) ;
  • You, Si-Young (Department of Internal Medicine, College of Medicine, ST. Vincent's Hospital, The Catholic University of Korea) ;
  • Choi, Hyun-Joo (Department of Pathology, College of Medicine, ST. Vincent's Hospital, The Catholic University of Korea) ;
  • Cho, Jung-Hae (Department of Otorhinolaryngology, College of Medicine, ST. Vincent's Hospital, The Catholic University of Korea) ;
  • Kim, Sung-Whan (Department of Radiation oncology, College of Medicine, ST. Vincent's Hospital, The Catholic University of Korea) ;
  • Lee, Jong-Hwan (Department of Internal Medicine, College of Medicine, ST. Vincent's Hospital, The Catholic University of Korea) ;
  • Kim, Young-Woon (Department of Internal Medicine, College of Medicine, ST. Vincent's Hospital, The Catholic University of Korea) ;
  • Kim, Hoon-Kyo (Department of Internal Medicine, College of Medicine, ST. Vincent's Hospital, The Catholic University of Korea)
  • 이수현 (가톨릭대학교 성빈센트병원 내과학교실) ;
  • 류시영 (가톨릭대학교 성빈센트병원 내과학교실) ;
  • 최현주 (가톨릭대학교 성빈센트병원 병리학교실) ;
  • 조정해 (가톨릭대학교 성빈센트병원 이비인후과학교실) ;
  • 김성환 (가톨릭대학교 성빈센트병원 방사선종양학교실) ;
  • 이종환 (가톨릭대학교 성빈센트병원 내과학교실) ;
  • 김영운 (가톨릭대학교 성빈센트병원 내과학교실) ;
  • 김훈교 (가톨릭대학교 성빈센트병원 내과학교실)
  • Received : 2012.04.24
  • Accepted : 2012.05.09
  • Published : 2012.05.25

Abstract

Small cell carcinoma mainly occurs in the lung. Approximately 2.5-5% of small cell carcinomas are primary extrapulmonary which are commonly found in the esophagus, GI tract, skin, uterus, and urinary tract. Small cell carcinoma of the head and neck is extremely rare and its prognosis is poor. We report a case of supraglottic small cell carcinoma with cervical lymph node and rib metastasis in a 75-year-old man. The patient was treated with sequential combination of chemotherapy and radiotherapy, but the cancer has progressed. We concluded that we have to find an effective therapy for laryngeal small cell carcinoma.

Keywords

References

  1. Levenson RM Jr, Ihde DC, Matthews MJ, Cohen MH, Gazdar AF, Bunn PA Jr, et al. Small cell carcinomapresenting as an extrapulmonaryneoplasm: Sites of origin and response to chemotherapy. J Natl Cancer Inst. 1981;67(3):607-612.
  2. Renner G. small cell carcinoma of the head and neck: A review. Semin Oncol. 2007;34(1):3-14.
  3. Galanis E, Frytak S, Lloyd RV. Extrapulmonarysmall cell carcinoma. Cancer. 1997;79(9):1729-1736.
  4. Choi YW, Jung JH, Jeong SH, Choi JH, Kim CH, Oh YT, et al. A case of primary small-cell carcinoma of the larynx. The Korean Journal of Medicine. 2009;76(Supp1):164-168.
  5. Barnard WG. The nature of the 'oat-celled sarcoma' of the mediastinum. J Pathol Baceriol. 1923;29:241-244.
  6. Morgan LC, Grayson D, Peters HE, Clarke CW, Peters MJ. Lung cancer in New south Wales: Current trends and the influence of age and sex. Med J Aust. 2000;192:578-582.
  7. Kim JH, Lee SH, Park J, Kim HY, Lee SI, Nam EM, et al. Extrapulmonary small-cell carcinoma: A single-institution experience. Jpn J Clin Oncol. 2004;34(5):250-254.
  8. Kaira K, Ishizuka T, Sohara N, Yanagitani N, Sunaga N, Tsuchiya T, et al. Small cell carcinoma of the larynx in a long-term survivor of small-cell lung cancer. J Clin Oncol. 2006;24(18):2961-2963.
  9. Kanazawa T, Nokubi M, Takizawa K, Matsuzawa S, Shinnabe A, Mineta H, et al. KIT and platelet-derivedgrowth factor receptor ${\alpha}$ gene expression in laryngeal small cell carcinoma. J Laryngol Otol. 2010;124(12):1340-1343.
  10. Lee JS, Lee KD, Lee CS, Yu TH, Lee GS, Hur B, et al. A case of small cell carcinoma of the larynx. Korea J Otolaryngol. 1994;37:167-173.
  11. Joo JB, Yoo SJ, Nam SY, Kim SY. The Non-Squamous Cell Cancers of the Larynx. Korea J Otolaryngol. 2001;44:1199-1205.
  12. Park CH, Roh JL, Park YH, Rha KS. A Case of Primary Small Cell Carcinoma of the Larynx. Korea J Otolaryngol. 2005;48:124-126.
  13. Hong JC, Rha SH, Lee HJ, Park HS. A Case of Small Cell Carcinoma of the Supraglottis. Korea J Otolaryngol-Head Neck Surg. 2010;53:784-786.
  14. Kim KO, Lee HY, Chun SH, Shin SJ, Kim MK, Lee KH, et al. Clinical Overview of Extrapulmonary Small Cell Carcinoma. J Korean Med Sci. 2006;21:833-837.
  15. Yuan ZY, Guan ZZ, Zhou ZM, Xia Y, Huang WZ, Yang XL. Extrapulmonary small cell carcinoma in 52 patients. Ai Zheng. 2006;25(9):1131-1133.
  16. Ferlito A, Silver CE, Bradford CR, Rinaldo A. Neuroendocrine neopal of the larynx: An overview. Head Neck. 2009;32(12):1634-1646.
  17. Weng CT, Chu PY, Liu MT, Chen MK. Small cell carcinoma of the head and neck: A single institution's experience and review of the literature. J Otolaryngol Head Neck Surg. 2008;37(6)788-793.