The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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Effects of Pueraria lobata on Body Weight and Gene Expression in Obese Rats Muscle with Estrogen Deficiency

갈근 추출물이 난소 적출로 비만이 유발된 Rat의 체중 변화와 유전자 발현에 미치는 영향

  • Shin, Hee-Jong (Dept. of Oriental Gynecology, College of Oriental Medicine, Dae-Jeon University) ;
  • Yoo, Jeong-Eun (Dept. of Oriental Gynecology, College of Oriental Medicine, Dae-Jeon University) ;
  • Jung, Eun-Hye (Dept. of Oriental Gynecology, College of Oriental Medicine, Dae-Jeon University) ;
  • Yoo, Dong-Youl (Dept. of Oriental Gynecology, College of Oriental Medicine, Dae-Jeon University)
  • 신희종 (대전대학교 한의과대학 한방부인과 교실) ;
  • 유정은 (대전대학교 한의과대학 한방부인과 교실) ;
  • 정은혜 (대전대학교 한의과대학 한방부인과 교실) ;
  • 유동열 (대전대학교 한의과대학 한방부인과 교실)
  • Received : 2012.07.26
  • Accepted : 2012.08.16
  • Published : 2012.08.31
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Abstract

Objectives: GG is the EtOH fraction of extract of Pueraria lobata. In this study, we aimed to elucidate a possibility that GG reduce obesity and obesity-derived complications such as cardiovascular and metabolic disease. Methods: The effects of GG on the estrogen-deficient obese rats and the level of gene expression in muscle of rats were investigated. Results: GG decreased body weight in obese rats with estrogen deficiency. GG increased leptin gene expression in obese rats with estrogen deficiency. GG decreased TNFa gene expression in obese rats with estrogen deficiency. And GG increased PPAR-gamma, PGC-1a, Prdx6, FDFT1, and ACC gene expression of those in obese rats. Conclusions: We conclude GG might reduce body weight and regulate gene expression of muscle in obese rats.

Keywords

References

  1. 대한비만학회. 임상비만학. 서울:고려의학. 2008:1, 12, 143.
  2. 한의부인과학 편찬위원회. 한의부인과학 上. 서울:도서출판 정담. 2001:383-4.
  3. Eckel RH. Obesity-mechanism and clinical management. USA:Lippincott Williams & Wilkins. 2003:3-102.
  4. Cooke PS, Naaz A. Role of Estrogens in Adipocyte Development and Function. Experimental biology and medicine. 2004;229(11):1127-35. https://doi.org/10.1177/153537020422901107
  5. 대한산부인과학회 교과서 편찬위원회. 부인과학 제4판. 서울:고려의학. 2007: 594-5.
  6. 한방약리학 교재편찬위원회. 한방약리학 제3판. 서울:신일북스. 2010:410-5.
  7. 부일권, 김연섭. 갈근이 뇌허혈 손상 흰쥐의 해마신경세포 손상에 미치는 영향. 대한본초학회지. 2004;19(1):77-82.
  8. 장승욱, 김연섭. 갈근(葛根)이 좌골신경 손상 흰쥐의 후지 근육위축에 미치는 영향. 동의생리병리학회지. 2009; 23(2):405-11.
  9. 홍재의 등. 갈근(葛根) 추출물이 cisplatin 에 의해 유도된 rat mesangial cell의 apoptosis에 미치는 영향. 동의생리병리학회지. 2010;24(2):220-7.
  10. 김홍배 등. 갈근추출액이 알레르기 염증반응에 미치는 영향. 대한한방소아과학회지. 2009;23(3):217-31.
  11. 구병삼. 임상 부인과 내분비학. 서울: 고려의학. 2001:228-31.
  12. Wellman GC et al. Gender differences in coronary artery diameter involve estrogen, nitric oxide, and Ca2+-dependent K+ channels. Circ. Res. 1996;79: 1024-30. https://doi.org/10.1161/01.RES.79.5.1024
  13. Kopelman PG. Effects of obesity on fat topography: metabolic and endocrine determinants. In: Clinical Obesity(1st ed.), edited by Kopelman PG and Stock MJ. Oxford, UK: Blackwell Science. 1998:158-75.
  14. Andreasen CH et al.. Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes, BMC Med Genet. 2009;10:17.
  15. Li MD. Leptin and beyond: an odyssey to the central control of body weight. Yale J Biol Med. 2011;84(1):1-7.
  16. Pedersen SB et al.. Estrogen controls lipolysis by up-regulating alpha2A adrenergic receptors directly in human adipose tissue through the estrogen receptor alpha. Implications for the female fat distribution. J. Clin. Endocrinol Metab. 2004;89:1869-78. https://doi.org/10.1210/jc.2003-031327
  17. Jensen MD. Lipolysis: contribution from regional fat. Annu Rev Nutr. 1997;17:127-39. https://doi.org/10.1146/annurev.nutr.17.1.127
  18. Yamamoto T et al. A novel coenzyme A : diacylglycerol acyltransferase 1 inhibitor stimulates lipid metabolism in muscle and lowers weight in animal models of obesity. Eur J Pharmacol. 2011;650(2-3):663-72. https://doi.org/10.1016/j.ejphar.2010.10.040
  19. Nakagami H, Morishita R. Obesity and gastrointestinal hormones-dual effect of angiotensin II receptor blockade and a partial agonist of PPAR-$\gamma$. Curr Vasc Pharmacol. 2011;9(2):162-6. https://doi.org/10.2174/157016111794519291
  20. 이상봉, 금동호, 이명종. 비만의 원인과 치료에 대한 동서의학적 고찰. 한의학연구소논문집. 1996;5(1):33-52.
  21. Matsuzawa Y et al. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol. 2004;24:29-33. https://doi.org/10.1161/01.ATV.0000099786.99623.EF
  22. Zhang W et al. Leptin modulated changes in adipose tissue protein expression in ob/ob mice. Obesity (Silver Spring). 2011;19(2):255-61. https://doi.org/10.1038/oby.2010.166

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