Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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Effect of quercetin on impaired immune function in mice exposed to irradiation

  • Jung, Ji-Hye (Division of Biological Science, College of Science, Sookmyung Women's University) ;
  • Kang, Ji-In (Division of Biological Science, College of Science, Sookmyung Women's University) ;
  • Kim, Hyun-Sook (Major in Food and Nutrition, College of Human Ecology, Sookmyung Women's University)
  • Received : 2012.01.18
  • Accepted : 2012.07.12
  • Published : 2012.08.31
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Abstract

Radiation used in cancer treatment may cause side effects such as inflammation. Quercetin is a polyphenol that reduces inflammation. This study evaluated the recovery efficacy of quercetin on impaired immune function in irradiation-induced inflammatory mice. Quercetin administered at two concentrations of 10 and 40 mg/kg body weight was initiated 2 weeks before irradiation and was continued 30 days after irradiation. The animals exposed/not exposed to radiation were sacrificed on radiation days 10 and 30. Splenocyte proliferation, which was diminished after irradiation, was enhanced significantly by quercetin supplementation after 30 days of irradiation. Cytokine secretion increased in the radiation group compared to that in the non-radiation control group. After 30 days of radiation, interleukin (IL)-$1{\beta}$ and IL-6 secretion decreased significantly in the radiation-quercetin groups. When quercetin was administered for 44 days, it showed a possible protective effect against irradiation-induced inflammation in mice. Quercetin could be beneficial in the recovery of irradiation-induced increases in cytokine secretion.

Keywords

References

  1. Kim SH, Jo SK, Kwon OD. The radioprotective effects of rhizomata herbs. J Radiat Prot 2001;26:13-18.
  2. Hertog MG, Hollman PC, Katan MB, Kromhout D. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands. Nutr Cancer 1993;20:21-29. https://doi.org/10.1080/01635589309514267
  3. Sharafetdinov KhKh, Plotnikova OA, Voznyi EK. Nutrition management of the cancer patients: modern view on problem. Vopr Pitan 2008;77:4-14.
  4. Mojzisova G, Kuchta M. Dietary flavonoids and risk of coronary heart disease. Physiol Res 2001;50:529-535.
  5. Giugliano D. Dietary antioxidants for cardiovascular prevention. Nutr Metab Cardiovasc Dis 2000;10:38-44.
  6. Halliwell B, Rafter J, Jenner A. Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not? Am J Clin Nutr 2005;81:268S-276S.
  7. Heo BG, Chon SU, Park YJ, Bae JH, Park SM, Park YS, Jang HG, Gorinstein S. Antiproliferative activity of Korean wild vegetables on different human tumor cell lines. Plant Foods Hum Nutr 2009;64:257-263. https://doi.org/10.1007/s11130-009-0138-8
  8. Bors W, Saran M. Radical scavenging by flavonoid antioxidants. Free Radic Res Commun 1987;2:289-294. https://doi.org/10.3109/10715768709065294
  9. Gavelová M, Hladíková J, Vildová L, Novotná R, Vondrácek J, Krcmár P, Machala M, Skálová L. Reduction of doxorubicin and oracin and induction of carbonyl reductase in human breast carcinoma MCF-7 cells. Chem Biol Interact 2008;176:9-18. https://doi.org/10.1016/j.cbi.2008.07.011
  10. Cai Q, Rahn RO, Zhang R. Dietary flavonoids, quercetin, luteolin and genistein, reduce oxidative DNA damage and lipid peroxidation and quench free radicals. Cancer Lett 1997;119:99-107. https://doi.org/10.1016/S0304-3835(97)00261-9
  11. Avila MA, Velasco JA, Cansado J, Notario V. Quercetin mediates the down-regulation of mutant p53 in the human breast cancer cell line MDA-MB468. Cancer Res 1994;54:2424-2428.
  12. Nagata H, Takekoshi S, Takeyama R, Homma T, Yoshiyuki Osamura R. Quercetin enhances melanogenesis by increasing the activity and synthesis of tyrosinase in human melanoma cells and in normal human melanocytes. Pigment Cell Res 2004;17:66-73. https://doi.org/10.1046/j.1600-0749.2003.00113.x
  13. Garabige V, Giraud P, De Rycke Y, Girod A, Jouffroy T, Jaulerry C, Brunin F, Rodriguez J. Impact of nutrition management in patients with head and neck cancers treated with irradiation: is the nutritional intervention useful? Cancer Radiother 2007;11: 111-116. https://doi.org/10.1016/j.canrad.2006.11.005
  14. Kamrava M, Bernstein MB, Camphausen K, Hodge JW. Combining radiation, immunotherapy, and antiangiogenesis agents in the management of cancer: the Three Musketeers or just another quixotic combination? Mol Biosyst 2009;5:1262-1270. https://doi.org/10.1039/b911313b
  15. Toda M, Wang L, Ogura S, Torii M, Kurachi M, Kakimi K, Nishikawa H, Matsushima K, Shiku H, Kuribayashi K, Kato T. UV irradiation of immunized mice induces type 1 regulatory T cells that suppress tumor antigen specific cytotoxic T lymphocyte responses. Int J Cancer 2011;129:1126-1136. https://doi.org/10.1002/ijc.25775
  16. Gaton DD, Lichter H, Avisar I, Slodovinic D, Solomon AS. Lymphocytic reaction to ultraviolet radiation on rabbit conjunctiva. Ann Ophthalmol (Skokie) 2007;39:128-133. https://doi.org/10.1007/s12009-007-0008-7
  17. Sgadari C, Angiolillo AL, Tosato G. Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10. Blood 1996;87:3877-3882.
  18. Gwak HS, Yoo HJ, Youn SM, Lee DH, Kim MS, Rhee CH. Radiosurgery for recurrent brain metastases after whole-brain radiotherapy : factors affecting radiation-induced neurological dysfunction. J Korean Neurosurg Soc 2009;45:275-283. https://doi.org/10.3340/jkns.2009.45.5.275
  19. Rao V, Chaukar D, D'Cruz AK. Hypercalcemia and treated breast cancers: the diagnostic dilemma. J Cancer Res Ther 2009;5:46-48. https://doi.org/10.4103/0973-1482.48770
  20. Barros GC, Labate RC. Psychological repercussions related to brachytherapy treatment in women with gynecological cancer: analysis of production from 1987 to 2007. Rev Lat Am Enfermagem 2008;16:1049-1053.
  21. Ghadjar P, Vock J, Vetterli D, Manser P, Bigler R, Tille J, Madlung A, Behrensmeier F, Mini R, Aebersold DM. Acute and late toxicity in prostate cancer patients treated by dose escalated intensity modulated radiation therapy and organ tracking. Radiat Oncol 2008;3:35. https://doi.org/10.1186/1748-717X-3-35
  22. Lee YR, Jung JH, Kim HS. Hesperidin partially restores impaired immune and nutritional function in irradiated mice. J Med Food 2011;14:475-482. https://doi.org/10.1089/jmf.2010.1269
  23. Kim KO, Chun M, Kang S, Kim HS. Effect of high protein diet and resveratrol supplementation on the nutritional status and immunoreactivity in the irradiation-induced inflammatory rats. Korean J Nutr 2009;42:605-614. https://doi.org/10.4163/kjn.2009.42.7.605
  24. Mishell BB, Shiigi SM. Selected Methods in Cellular Immunology. San Francisco: Freeman; 1980.
  25. Gosselin TK, Gilliard L, Tinnen R. Assessing the need for a dietitian in radiation oncology. Clin J Oncol Nurs 2008;12:781-787. https://doi.org/10.1188/08.CJON.781-787
  26. Bhanja P, Saha S, Kabarriti R, Liu L, Roy-Chowdhury N, Roy-Chowdhury J, Sellers RS, Alfieri AA, Guha C. Protective role of R-spondin1, an intestinal stem cell growth factor, against radiation-induced gastrointestinal syndrome in mice. PLoS One 2009;4:e8014. https://doi.org/10.1371/journal.pone.0008014
  27. Nagai H, Nishiyori T, Ochi T, Imai Y, Tanaka H, Inagaki N. The effect of methanolic extract from Corydalis Tuber on cytokine production and allergic reactions in experimental animals. J Tradit Med 1999;16:51-57.
  28. Peter W. Understanding Immunology. 2nd edition. Harlow, England: Pearson Prentice Hall; 2006. p. 98-110.
  29. Taylor CW, Nisbet A, McGale P, Darby SC. Cardiac exposures in breast cancer radiotherapy: 1950s-1990s. Int J Radiat Oncol Biol Phys 2007;69:1484-1495. https://doi.org/10.1016/j.ijrobp.2007.05.034
  30. Yokoyama Y, Sakamoto K, Arai M, Akagi M. Radiation and surgical stress induce a significant impairment in cellular immunity in patients with esophageal cancer. Jpn J Surg 1989;19:535-543. https://doi.org/10.1007/BF02471660
  31. Batista FD, Harwood NE. The who, how and where of antigen presentation to B cells. Nat Rev Immunol 2009;9:15-27. https://doi.org/10.1038/nri2454
  32. Osada J, Kamocki Z, Rusak M, Dabrowska M, Kedra B. The effect of surgical and nutritional treatment on activation parameters of peripheral blood T lymphocytes in stomach cancer patients in postoperative period. Pol Merkur Lekarski 2008;24:231-236.
  33. Jiang W, Kang L, Lu HZ, Pan X, Lin Q, Pan Q, Xue Y, Weng X, Tang YW. Normal values for CD4 and CD8 lymphocyte subsets in healthy Chinese adults from Shanghai. Clin Diagn Lab Immunol 2004;11:811-813.
  34. Nagel JE, Chopra RK, Chrest FJ, McCoy MT, Schneider EL, Holbrook NJ, Adler WH. Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors. J Clin Invest 1988;81:1096-1102. https://doi.org/10.1172/JCI113422
  35. Rechcinski T, Grebowska A, Kurpesa M, Sztybrych M, Peruga JZ, Trzos E, Rudnicka W, Krzeminska-Pakua M, Chmiela M. Interleukin-1b and interleukin-1 receptor inhibitor gene cluster polymorphisms in patients with coronary artery disease after percutaneous angioplasty or coronary artery bypass grafting. Kardiol Pol 2009;67:601-610.
  36. Meng Z, Liu Y, Wu D. Effect of sulfur dioxide inhalation on cytokine levels in lungs and serum of mice. Inhal Toxicol 2005; 17:303-307. https://doi.org/10.1080/08958370590922625
  37. Meydani SN. Dietary modulation of cytokine production and biologic functions. Nutr Rev 1990;48:361-369.
  38. Wu KS, Zhou X, Zheng F, Xu XQ, Lin YH, Yang J. Influence of interleukin-1 beta genetic polymorphism, smoking and alcohol drinking on the risk of non-small cell lung cancer. Clin Chim Acta 2010;411:1441-1446. https://doi.org/10.1016/j.cca.2010.05.035
  39. Hepgul G, Tanrikulu S, Unalp HR, Akguner T, Erbil Y, Olgac V, Ademoglu E. Preventive effect of pentoxifylline on acute radiation damage via antioxidant and anti-inflammatory pathways. Dig Dis Sci 2010;55:617-625. https://doi.org/10.1007/s10620-009-0780-x
  40. Calveley VL, Khan MA, Yeung IW, Vandyk J, Hill RP. Partial volume rat lung irradiation: temporal fluctuations of in-field and out-of-field DNA damage and inflammatory cytokines following irradiation. Int J Radiat Biol 2005;81:887-899. https://doi.org/10.1080/09553000600568002
  41. Van Cutsem E, Arends J. The causes and consequences of cancer-associated malnutrition. Eur J Oncol Nurs 2005;9 Suppl 2:S51-S63.
  42. Isenring EA, Bauer JD, Capra S. Nutrition support using the American Dietetic Association medical nutrition therapy protocol for radiation oncology patients improves dietary intake compared with standard practice. J Am Diet Assoc 2007;107:404-412. https://doi.org/10.1016/j.jada.2006.12.007
  43. Rockenbach G, Di Pietro PF, Ambrosi C, Boaventura BC, Vieira FG, Crippa CG, Da Silva EL, Fausto MA. Dietary intake and oxidative stress in breast cancer: before and after treatments. Nutr Hosp 2011;26:737-744.
  44. Kroner A, Stoll H, Spichiger E. Malnutrition and weight lossnurse assessment of nutritional status and counselling: experiences of patients with newly diagnosed or relapsed cancer. Pflege 2012;25:85-95. https://doi.org/10.1024/1012-5302/a000184
  45. Noroozi M, Burns J, Crozier A, Kelly IE, Lean ME. Prediction of dietary flavonol consumption from fasting plasma concentration or urinary excretion. Eur J Clin Nutr 2000;54:143-149. https://doi.org/10.1038/sj.ejcn.1600908
  46. Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited. FASEB J 2008;22:659-661.
  47. Ghosh A, Mandal AK, Sarkar S, Panda S, Das N. Nanoencapsulation of quercetin enhances its dietary efficacy in combating arsenic-induced oxidative damage in liver and brain of rats. Life Sci 2009;84:75-80. https://doi.org/10.1016/j.lfs.2008.11.001

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