Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
권호 표지
DOI QR코드

DOI QR Code

Recent incidence of congenital heart disease in neonatal care unit of secondary medical center: a single center study

  • Cho, Seon-Young (Department of Pediatrics, The Catholic University of Korea School of Medicine) ;
  • Oh, Jin-Hee (Department of Pediatrics, The Catholic University of Korea School of Medicine) ;
  • Lee, Jung-Hyun (Department of Pediatrics, The Catholic University of Korea School of Medicine) ;
  • Lee, Jae-Young (Department of Pediatrics, The Catholic University of Korea School of Medicine) ;
  • Lee, Soon-Ju (Department of Pediatrics, The Catholic University of Korea School of Medicine) ;
  • Han, Ji-Whan (Department of Pediatrics, The Catholic University of Korea School of Medicine) ;
  • Koh, Dae-Kyun (Department of Pediatrics, The Catholic University of Korea School of Medicine) ;
  • Oh, Chang-Kyu (Department of Pediatrics, The Catholic University of Korea School of Medicine)
  • Received : 2011.03.17
  • Accepted : 2012.01.31
  • Published : 2012.07.15
Download PDF
⟨ Previous Next ⟩

Abstract

Purpose: With feasibility in the diagnoses of congenital heart disease (CHD) in the antenatal period, we suspect changes have occurred in its incidence. No data have been reported about the current incidence of simple forms of CHD in Korea. We have attempted to assess the recent incidence and characteristics of CHD in the neonatal care unit of a secondary referral medical center. Methods: Medical records of 497 neonatal care unit patients who underwent echocardiography in the past 5 years were reviewed. Preterm infants with patent ductus arteriosus and other transient, minimal lesions were excluded from this study. Results: Although the number of inpatients remained stable, the incidence of simple forms of CHD showed a gradual decrease over the 5-year study period; a markedly low incidence of complex forms was seen as well. CHD was observed in 3.7% full-term and 6.8% pre-term infants. CHD was observed in 152 infants weighing >2,500 g (3.5% of corresponding birth weight infants); 65 weighing 1,000 to 2,500 g (9.3%); and 6 weighing <1,000 g (8.0%). The incidence of CHD was higher in the pre-term group and the low birth weight group than in each corresponding subgroup (P<0.001); however, the incidence of complex CHD in full-term neonates was high. The number of patients with extracardiac structural anomalies has also shown a gradual decrease every year for the past 5 years. Conclusion: Findings from our study suggest that the recent incidence and disease pattern of CHD might have changed for both complex and simple forms of CHD in Korea.

Keywords

References

  1. Mitchell SC, Korones SB, Berendes HW. Congenital heart disease in 56,109 births. Incidence and natural history. Circulation 1971;43:323-32. https://doi.org/10.1161/01.CIR.43.3.323
  2. Grech V, Gatt M. Syndromes and malformations associated with congenital heart disease in a population-based study. Int J Cardiol 1999; 68:151-6. https://doi.org/10.1016/S0167-5273(98)00354-4
  3. Jung SC, Kim SS, Yoon KS, Lee JS. Prevalence of congenital malformations and genetic diseases in Korea. J Hum Genet 1999;44:30-4. https://doi.org/10.1007/s100380050102
  4. Hoffman JI. Incidence of congenital heart disease: I. Postnatal incidence. Pediatr Cardiol 1995;16:103-13. https://doi.org/10.1007/BF00801907
  5. Kovalchin JP, Silverman NH. The impact of fetal echocardiography. Pediatr Cardiol 2004;25:299-306.
  6. Chung ML, Lee BS, Kim EA, Kim KS, Pi SY, Oh YM, et al. Impact of fetal echocardiography on trends in disease patterns and outcomes of congenital heart disease in a neonatal intensive care unit. Neonatology 2010;98:41-6. https://doi.org/10.1159/000264673
  7. Levey A, Glickstein JS, Kleinman CS, Levasseur SM, Chen J, Gersony WM, et al. The impact of prenatal diagnosis of complex congenital heart disease on neonatal outcomes. Pediatr Cardiol 2010;31:587-97. https://doi.org/10.1007/s00246-010-9648-2
  8. Geggel RL. Conditions leading to pediatric cardiology consultation in a tertiary academic hospital. Pediatrics 2004;114:e409-17. https://doi.org/10.1542/peds.2003-0898-L
  9. Jung JW, Kim NS, Lee SY, Park IS. Recent trends in the frequency of congenital heart diseases: nationwide survey in Korea [abstract]. In: The 3rd Congress of Asia-Pacific Pediatric Cardiac Society; 2010 Jul 6-8; Chiba, Japan. 2010. p. 225.
  10. Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol 2002;39:1890-900. https://doi.org/10.1016/S0735-1097(02)01886-7
  11. Lee JE, Jung KL, Kim SE, Nam SH, Choi SJ, Oh SY, et al. Prenatal diagnosis of congenital heart disease: trends in pregnancy termination rate, and perinatal and 1-year infant mortalities in Korea between 1994 and 2005. J Obstet Gynaecol Res 2010;36:474-8. https://doi.org/10.1111/j.1447-0756.2010.01222.x
  12. Wu MH, Chen HC, Lu CW, Wang JK, Huang SC, Huang SK. Prevalence of congenital heart disease at live birth in Taiwan. J Pediatr 2010; 156:782-5. https://doi.org/10.1016/j.jpeds.2009.11.062
  13. Yang XY, Li XF, Lu XD, Liu YL. Incidence of congenital heart disease in Beijing, China. Chin Med J (Engl) 2009;122:1128-32.
  14. Khoshnood B, De Vigan C, Vodovar V, Goujard J, Lhomme A, Bonnet D, et al. Trends in prenatal diagnosis, pregnancy termination, and perinatal mortality of newborns with congenital heart disease in France, 1983-2000: a population-based evaluation. Pediatrics 2005;115:95-101. https://doi.org/10.1542/peds.2004-0516
  15. Malik S, Cleves MA, Zhao W, Correa A, Hobbs CA; National Birth Defects Prevention Study. Association between congenital heart defects and small for gestational age. Pediatrics 2007;119:e976-82. https://doi.org/10.1542/peds.2006-2742
  16. Godfrey M, Schimmel MS, Hammerman C, Farber B, Glaser J, Nir A. The incidence of congenital heart defects in very low birth weight and extremely low birth weight infants. Isr Med Assoc J 2010;12:36-8.
  17. Tanner K, Sabrine N, Wren C. Cardiovascular malformations among preterm infants. Pediatrics 2005;116:e833-8. https://doi.org/10.1542/peds.2005-0397
  18. Dees E, Lin H, Cotton RB, Graham TP, Dodd DA. Outcome of preterm infants with congenital heart disease. J Pediatr 2000;137:653-9. https://doi.org/10.1067/mpd.2000.108568
  19. Kecskes Z, Cartwright DW. Poor outcome of very low birthweight babies with serious congenital heart disease. Arch Dis Child Fetal Neonatal Ed 2002;87:F31-3. https://doi.org/10.1136/fn.87.1.F31
  20. Kapoor R, Gupta S. Prevalence of congenital heart disease, Kanpur, India. Indian Pediatr 2008;45:309-11.
  21. Forrester MB, Merz RD. Descriptive epidemiology of selected congenital heart defects, Hawaii, 1986-1999. Paediatr Perinat Epidemiol 2004;18:415-24. https://doi.org/10.1111/j.1365-3016.2004.00594.x
  22. Stephensen SS, Sigfusson G, Eiriksson H, Sverrisson JT, Torfason B, Haraldsson A, et al. Congenital cardiac malformations in Iceland from 1990 through 1999. Cardiol Young 2004;14:396-401. https://doi.org/10.1017/S1047951104004081
  23. Samánek M, Vorískova M. Congenital heart disease among 815,569 children born between 1980 and 1990 and their 15-year survival: a prospective Bohemia survival study. Pediatr Cardiol 1999;20:411-7. https://doi.org/10.1007/s002469900502
  24. Robida A, Folger GM, Hajar HA. Incidence of congenital heart disease in Qatari children. Int J Cardiol 1997;60:19-22. https://doi.org/10.1016/S0167-5273(97)00067-3
  25. Begic H, Tahirovic H, Mesihovic-Dinarevic S, Ferkovic V, Atic N, Latifagic A. Epidemiological and clinical aspects of congenital heart disease in children in Tuzla Canton, Bosnia-Herzegovina. Eur J Pediatr 2003;162:191-3.

Cited by

  1. Clinical profile and pattern of congenital heart disease in infants of diabetic mother and infants of non-diabetic mother at a tertiary care hospital vol.10, pp.4, 2012, https://doi.org/10.3233/npm-170176
  2. Clinical Features of Critical Congenital Heart Disease in Term Infants with Hypoxemia: A Single-Center Study in Korea vol.25, pp.4, 2012, https://doi.org/10.5385/nm.2018.25.4.137
  3. Predictive Value of Vasoactive-inotropic Score for Mortality in Newborns Undergoing Cardiac Surgery vol.56, pp.9, 2012, https://doi.org/10.1007/s13312-019-1639-7