Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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hOGG1, p53 Genes, and Smoking Interactions are Associated with the Development of Lung Cancer

  • Cheng, Zhe (Department of Respiratory Medicine, the First Affiliated Hospital of Zhengzhou University, Institute of Clinical Medical Research of Henan Universities) ;
  • Wang, Wei (Department of Respiratory Medicine, the First Affiliated Hospital of Zhengzhou University, Institute of Clinical Medical Research of Henan Universities) ;
  • Song, Yong-Na (Department of Respiratory Medicine, the First Affiliated Hospital of Zhengzhou University, Institute of Clinical Medical Research of Henan Universities) ;
  • Kang, Yan (Department of Respiratory Medicine, the First Affiliated Hospital of Zhengzhou University, Institute of Clinical Medical Research of Henan Universities) ;
  • Xia, Jie (Department of Respiratory Medicine, the First Affiliated Hospital of Zhengzhou University, Institute of Clinical Medical Research of Henan Universities)
  • Published : 2012.05.30
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Abstract

This study aimed to investigate the effects of Ser/Cys polymorphism in hOGG1 gene, Arg/Pro polymorphism in p53 gene, smoking and their interactions on the development of lung cancer. Ser/Cys polymorphism in hOGG1 and Arg/Pro polymorphism in p53 among 124 patients with lung cancer and 128 normal people were detected using PCR-RFLP. At the same time, smoking status was investigated between the two groups. Logistic regression was used to estimate the effects of Ser/Cys polymorphism and Arg/Pro polymorphisms, smoking and their interactions on the development of lung cancer. ORs (95% CI) of smoking, hOGG1 Cys/Cys and p53 Pro/Pro genotypes were 2.34 (1.41-3.88), 2.12 (1.03-4.39), and 2.12 (1.15-3.94), respectively. The interaction model of smoking and Cys/Cys was super-multiplicative or multiplicative, and the OR (95% CI) for their interaction item was 1.67 (0.36 -7.78). The interaction model of smoking and Pro/Pro was super-multiplicative with an OR (95%CI) of their interaction item of 5.03 (1.26-20.1). The interaction model of Pro/Pro and Cys/Cys was multiplicative and the OR (95%CI) of their interaction item was 0.99 (0.19-5.28). Smoking, hOGG1 Cys/Cys, p53 Pro/Pro and their interactions may be the important factors leading to the development of lung cancer.

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References

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