Journal of the Korean Society of Radiology (한국방사선학회논문지)

The Korean Society of Radiology (한국방사선학회)
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Usefulness of Gastric Emptying Time Test for Dog byUsing Radiopaque Marker KOLOMARK

비투과 표지자 KOLOMARK를 이용한 개의 위배출시간검사에 대한 유용성

  • Cho, Young-Kwon (Department of Radiological Technology, Daegu Health college) ;
  • Kim, Seon-Chil (Department of Radiological Technology, Daegu Health college)
  • 조영권 (대구보건대학교 방사선과) ;
  • 김선칠 (대구보건대학교 방사선과)
  • Received : 2012.04.25
  • Accepted : 2012.08.14
  • Published : 2012.08.30
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Abstract

Abnormal gastric emptying time of dog by alien substance, neoplasm, pyloric antrum hyperplasia, stomach surgery, electrolyte imbalance, stomach-dilated torsion is clinically important as a digestive disease. Therefore study aims to provide basic data on the clinical usefulness of gastric emptying time test which uses radiopaque Kolomark developed in Korea rather than using the existing BIPS for the dog. 9 beagles were used for this experiment and their average weight was about 10.3kg with 2.5 year-old average age. For the test, fast for 12 hours was made without chemical sedation, and just before the test, 1 capsule of Kolomark was fed with 25% of daily feed amount, and we took photographs at ventrodorsal and right lateral position after 2, 4, 8 and 12 hours. As for interested reading area, we observed entire stomach from cardia to stomach pyloric part, and as for analysis method, we counted Kolomarks remained in the stomach per time and judged only P value below 0.05 to be meaningful by using Friedman Test. After feeding Kolomark through oral cavity, it took average 7.55 hours for the Kolomark to have escaped from the stomach to small intestine. In this study of gastrointestinal tract passing time after feeding matured dog, we used Kolomark and expect that it could be a basic data for normal gastrokinetic time.

개에서 이물, 신생물, 유문동비후, 위수술, 전해질불균형, 위확장성 염전 등에 의한 비정상적인 위 배출시간은 임상에서 소화기 질환으로 중요하다. 그러므로 위장관 운동이상에 대한 정확한 진단을 위하여 정상적인 위장관 운동시간에 대한 자료가 필요하다. 이 연구의 목적은 개에서 기존의 BIPS를 이용하는 검사 방식이 아닌 국내에서 개발한 방사선 비투과성 Kolomark를 이용한 위배출시간 검사에 대한 임상적 유용성에 대한 기초자료를 제공하기 위한 것이다. Beagle 9마리가 이번 실험에 사용되었으며 평균 체중 평균 10.3kg이며 평균 2.5살이었다. 검사를 위해 12시간 금식을 시행하였으며 화학적 보정은 하지 않은 채 검사 직전 하루 사료급여량의 25%용량에 Kolomark 1개의 capsule과 함께 급여하였고 2, 4, 8, 12시간 때 Ventrodorsal, Right lateral자세로 촬영하였다. 관심판독부분은 분문에서 위유문부까지의 위장 전체를 관찰하였으며 분석방법으로는 각 시간대별로 위장 내에 남아있는 Kolomark를 카운트하여 비모수검정인 Friedman 검정방법을 이용하여 P값이 0.05 미만인 경우를 유의한 것으로 판정하였다. 구강으로 Kolomark를 섭식 후 위에서 소장으로 완전히 Kolomark가 빠져나가는데 걸리는 평균시간은 7.55시간이었다. 이번 연구에서 성숙한 개에서 음식물 투여 후에 나타나는 위장관 통과시간을 Kolomark를 이용하여 정상적인 위장관 운동시간에 대한 기초자료가 되리라 판단된다.

Keywords

References

  1. Strombeck DR, Guilford W, Small animal gastroenterology, 2nd, Davis, Stonegate, 1990.
  2. Chaudhuri TK, Fink S, Gastric emptying in human disease states,Am J Gastroenterol,Vol.86, pp.553-558, 1991.
  3. Proano M, Camilleri M, Phillips SF, Brown ML,Thomforde GM, Transit of solids through the human colon: regional quantification in the unprepared bowel, Am J Physiol, Vol. 258, pp.856-862, 1990.
  4. Stivland T, Camilleri M, Vassallo M, et al.Scintigraphic measurement of regional gut transit in idiopathic constipation, Gastroenterology, Vol. 101, pp.107-115, 1991. https://doi.org/10.1016/0016-5085(91)90466-X
  5. Notghi A, Hutchinson R, Kumar D, Smith NB, Harding LK, Simplified method for the measurement of segmental colonic transit time,Gut, Vol. 35, pp.976-981, 1994. https://doi.org/10.1136/gut.35.7.976
  6. Charles F, Camillei M, Phillips SF, Thomforde GM, Forstrom LA, Scintigraphy of the whole gut: clinical evaluation of transit disorders, Mayo Clin Proc, Vol. 70, pp.113-118, 1995. https://doi.org/10.4065/70.2.113
  7. suck chei Choi, je hyung Kim, ho geun Hwang et al.Scintigraphic measurement of regional colonic transit time in healthy controls, KjG, Vol. 29, pp.1-8, 1997.
  8. Burton DD, Camilleri M, Mullan BP, et al. Colonic transit scintigraphy labeled activated charcoal compared with ion exchange pellets, J Nucl Med, Vol. 38, pp.1807-1810, 1997.
  9. Choi MG, Choi H, Choi KY, et al. Delayed releasing radiopaque markers test for measurement of colonic transit: comparison with radioactivated charcoal scintigraphy, Gastroenterology, Vol. 116, A222, 1999.
  10. Bartholomeusz D, Chatterton BE, Bellen JC, et al. Segmental colonic transit after oral 67Ga-citrate in healthy subjects and those with chronic idiopathic constipation, J Nucl Med, Vol. 40 pp.277-282, 1999.
  11. Frazer J. Allan BVSc, MVSc, W. et al.GASTRIC EMPTYING OF SOLID RADIOPAQUE MARKERS IN HEALTHY DOGS, Vet Radiol Ultrasound, Vol. 37, No.5, pp.336-344, 1996. https://doi.org/10.1111/j.1740-8261.1996.tb01238.x
  12. Colmer MR, Owen GM, Shields R, Patterns of gastric emptying after vagotomy and pyloroplasty, Br Med J, ii, pp.448-450, 1973.
  13. Bruse SJ, Hedderley DI, Guiford WG, et al. Development of reference intervals for the large intestinal transit of radiopaque markers in dogs, Vet Radiol Ultrasound, Vol. 40, No. 5, pp.472-476, 1999. https://doi.org/10.1111/j.1740-8261.1999.tb00377.x
  14. Lester, Roberts, Newell, Assessment of barium impregnated polyethylene spheres (BIPS) as a measure of solid-phase gastric emptying in normal dogs-comparison to scintigraphy, Vet Radiol Ultrasound, Vol. 40, No. 5, pp.465-471. 1999. https://doi.org/10.1111/j.1740-8261.1999.tb00376.x
  15. Kim, J.E., Rhee, P.L., Kim, Y.H. et al. Clinical usefulness of Kolomark TM, a Korean radioopaque marker for measuring colon transit time, Korean J. Intern Med, Vol. 60, No. 4, pp.337-341, 2001.
  16. Kim, D.Y., H.K.,Lee, Y.H, Jung, The measurement of gastric emptying time with 3-D ultrasonography, Korean J.Gastroenterol, Vol. 44, pp.71-76, 2004.
  17. Won, H.H., Choi, M.C. and Lee H.J, Ultrasonographic observation of gastric motility in dogs, Korean J.Vet. Clin. Med, Vol. 17 No.2, pp.403-410, 2000.
  18. Urbain, J.L. and Charkes, N.D, Recent advances in gastric emptying scintigraphy, Semin. Nucl. Med, Vol. 25, No. 4, pp.318-325, 1995. https://doi.org/10.1016/S0001-2998(95)80005-0
  19. Williams CL, Peterson JM, Villar G, Burkds TF, Corticotrophinreleasing factor directly mediates colonic responses to stress, Am J Physiol, Vol. 253, pp.582-586, 1987.
  20. Madsen JL, Effects of gender, age, and body mass index on gastrointestinal transit times, Dig Dis Sci, Vol. 37, pp.1548-1553, 1992. https://doi.org/10.1007/BF01296501
  21. Goggin JM, Hoskinson JJ, Kirk CA, Jewell D, Butine MD, Comparison of gastric emptying times in healthy cats simultaneously evaluated with radiopaque markers and nuclear scintigraphy, Vet Radiol Ultrasound, Vol. 40, No. 1, pp.89-95, 1999. https://doi.org/10.1111/j.1740-8261.1999.tb01845.x
  22. Lewis LD, Morris ML, Hand MS. Small animal clinical nutrition 111, Kansas, Mark Morris Associates, 1987.