YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effects of Herbal Complex, YJ-1, on Atopic Dermatitis in NC/Nga Mice Model

NC/Nga 마우스에서 생약 복합 조성물 YJ-1의 아토피성 피부염 치료 효능

  • Lee, Geum-Seon (College of Pharmacy & Institute of Chronic Disease, Sahmyook University) ;
  • Lee, Ki-Man (College of Pharmacy & Institute of Chronic Disease, Sahmyook University) ;
  • Shim, Hong (College of Pharmacy & Institute of Chronic Disease, Sahmyook University) ;
  • Kim, Jin-Hong (Yeun Jung Bio Co.) ;
  • Cheong, Jae-Hoon (College of Pharmacy & Uimyung Research Institute for Neuroscience, Sahmyook University) ;
  • Kang, Tae-Jin (College of Pharmacy & Institute of Chronic Disease, Sahmyook University)
  • 이금선 (삼육대학교 약학대학, 만성병 연구소) ;
  • 이기만 (삼육대학교 약학대학, 만성병 연구소) ;
  • 심홍 (삼육대학교 약학대학, 만성병 연구소) ;
  • 김진홍 ((주) YJbio) ;
  • 정재훈 (삼육대학교 약학대학, 의명신경과학연구소) ;
  • 강태진 (삼육대학교 약학대학, 만성병 연구소)
  • Received : 2012.01.20
  • Accepted : 2012.03.06
  • Published : 2012.04.30
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Abstract

This study was conducted to determine if YJ-1, a novel herbal complex from a mixture of six oriental herbs (Hydnocarpi Semen, Sesami Semen, Dictamni Radicis Cortex, Momordicae Semen, Xanthii Fructus, and Sophorae Radix), has therapeutic properties for the treatment of atopic dermatitis (AD). Using AD like symptom-induced NC/Nga mice by 1-chloro 2,4-dinitrobenzene (DNCB), the effectiveness of YJ-1 on AD was evaluated. Elidel cream$^{(R)}$ (1% pimecrolimus) was used as a control. Dermal application of YJ-1 reduced major clinical signs of AD such as erythema, pruritus, lichenification, edema/escoriations, and dryness. Interestingly, YJ-1 more improved AD-related symptoms including decrease of spleen weight, IL-4, and IgE level in the serum as well as reduction of scratching counts and clinical skin severity in the NC/Nga AD mouse model. Especially, treatment of YJ-1 at 20% in NC/Nga mice more effected than Elidel cream. These results suggest that the ointment of YJ-1 may enhance the process of AD healing by alleviating allergic reaction and has potential for therapeutic reagent for the treatment of AD.

Keywords

References

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