한국약용작물학회지 (Korean Journal of Medicinal Crop Science)

  • 제20권4호
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  • Pages.245-250
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  • 2012
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  • 1225-9306(pISSN)
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  • 2288-0186(eISSN)
한국약용작물학회 (The Korean Society of Medicinal Crop Science)
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Dieldrin에 의한 DNA와 세포 손상에 대한 오가피 추출물의 억제효과

Suppressive Effect of Acanthopanax sessiliflorus Extract on the DNA and Cell Damage by Dieldrin

  • 류아름 (순천향대학교 의료생명공학과) ;
  • 김지혜 (순천향대학교 의료생명공학과) ;
  • 이미영 (순천향대학교 의료생명공학과)
  • Ryu, A-Reum (Department of Medical Biotechnology, Soonchunhyang University) ;
  • Kim, Ji-Hae (Department of Medical Biotechnology, Soonchunhyang University) ;
  • Lee, Mi-Young (Department of Medical Biotechnology, Soonchunhyang University)
  • 투고 : 2012.07.26
  • 심사 : 2012.08.07
  • 발행 : 2012.08.30
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초록

Dieldrin, one of the organochlorine pesticides (OCPs), induced the damages in neuroblastoma cells and DNA damages in lymphocytes. The ethanol extracts of A. sessiliflorus leaves were examined for the suppressive effects on the dieldrin-induced cell damages. Moreover, the extract was used to test whether it might inhibit the oxidative DNA damage of lymphocytes using Comet assay. The cell and DNA damage by dieldrin were suppressed in vitro upon treating A. sessiliflorus extract. This result suggests that A. sessiliflorus extract might be useful to reduce dieldrin toxicity.

키워드

참고문헌

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  2. Effect of Acanthopanax sessiliflorus Extracts on Stress Response and Aging in Caenorhabditis elegans vol.19, pp.3, 2013, https://doi.org/10.3136/fstr.19.439
  3. Effect of Shading and Pinching on Growth and Acanthoside-D content of Acanthopanax divaricatus var. albeofructus and Acanthopanax koreanum Nakai vol.21, pp.1, 2013, https://doi.org/10.7783/KJMCS.2013.21.1.39
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