Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Suppressive Effect of Acanthopanax sessiliflorus Extract on the DNA and Cell Damage by Dieldrin

Dieldrin에 의한 DNA와 세포 손상에 대한 오가피 추출물의 억제효과

  • Ryu, A-Reum (Department of Medical Biotechnology, Soonchunhyang University) ;
  • Kim, Ji-Hae (Department of Medical Biotechnology, Soonchunhyang University) ;
  • Lee, Mi-Young (Department of Medical Biotechnology, Soonchunhyang University)
  • 류아름 (순천향대학교 의료생명공학과) ;
  • 김지혜 (순천향대학교 의료생명공학과) ;
  • 이미영 (순천향대학교 의료생명공학과)
  • Received : 2012.07.26
  • Accepted : 2012.08.07
  • Published : 2012.08.30
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Abstract

Dieldrin, one of the organochlorine pesticides (OCPs), induced the damages in neuroblastoma cells and DNA damages in lymphocytes. The ethanol extracts of A. sessiliflorus leaves were examined for the suppressive effects on the dieldrin-induced cell damages. Moreover, the extract was used to test whether it might inhibit the oxidative DNA damage of lymphocytes using Comet assay. The cell and DNA damage by dieldrin were suppressed in vitro upon treating A. sessiliflorus extract. This result suggests that A. sessiliflorus extract might be useful to reduce dieldrin toxicity.

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References

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