Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Modifying Effect of Diallyl Sulfide on Colon Carcinogenesis in C57BL/6J-ApcMin/+ Mice

  • Kang, Jin-Seok (Department of Biomedical Laboratory Science, Namseoul University) ;
  • Kim, Tae-Myoung (College of Veterinary Medicine & Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Shim, Tae-Jin (College of Veterinary Medicine & Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Salim, Elsayed I. (Department of Zoology, Tanta University) ;
  • Han, Beom-Seok (Division of Toxicopathology, Hoseo Toxicology Research Center, Hoseo University) ;
  • Kim, Dae-Joong (College of Veterinary Medicine & Research Institute of Veterinary Medicine, Chungbuk National University)
  • Published : 2012.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

Diallyl sulfide (DAS), a flavoring compound derived from garlic, is considered to have cancer chemopreventive potential in experimental animals and humans. This study was designated to examine possible chemopreventive effects of DAS on colon carcinogenesis using genetically engineered transgenic $Apc^{Min/+}$ mice, a well-established animal model for familial adenomatous polyposis (FAP) and sporadic colorectal cancer. Male C57BL/6J-$Apc^{Min/+}$ mice were divided into three groups. Animals of group 1 were placed on the basal diet (AIN-76A) as non-treated controls. Animals of groups 2 and 3 were given DAS-containing diets (in doses of 100 and 300 ppm, respectively). All mice were sacrificed at the end of week 10 of the experiment. Histopathological investigation revealed that the incidence of colonic polyps was decreased dose-dependently by 19% (13/16) in group 2 and by 32% (13/20) in group 3 compared to the 100% incidence (10/10) in group 1. The multiplicity of colonic polyps per mouse was also slightly decreased by DAS treatment ($1.88{\pm}0.35$ in group 2 and $1.63{\pm}0.36$ in group 3) compared to $2.00{\pm}0.39$ in group 1. On the other hand, there were no significant differences in the numbers of total polyps per mouse in the small intestine between the groups. Taken together, we suggest that DAS may exert promising inhibitory effects on colon carcinogenesis in the transgenic $Apc^{Min/+}$ mice.

Keywords

References

  1. Boolbol SK, Dannenberg AJ, Chadburn A, et al (1996). Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis. Cancer Res, 56, 2556-60.
  2. Groden J, Thliveris A, Samowitz W, et al (1991). Identification and characterization of the familial adenomatous polyposis coli gene. Cell, 66, 589-600. https://doi.org/10.1016/0092-8674(81)90021-0
  3. Herman-Antosiewicz A, Singh SV (2004). Signal transduction pathways leading to cell cycle arrest and apoptosis induction in cancer cells by allium vegetable-derived organosulfur compounds: a review. Mutat Res, 555, 121- 31. https://doi.org/10.1016/j.mrfmmm.2004.04.016
  4. Kang JS, Kim DJ, Jang DD (2000). The modifying effect of indole-3-carbinol (I3C) and its metabolites, phytochemicals from Cruciferae vegetables, in chemical carcinogenesis and cancer prevention. J Korean Assoc Cancer Prev, 5, 199-208.
  5. Kelloff GJ, Crowell JA, Steele VE, et al (2000). Progress in cancer chemoprevention: development of diet-derived chemopreventive agents. J Nutr, 130, 467-71S.
  6. Khanum F, Anilakumar KR, Viswanathan KR (2004). Anticarcinogenic properties of garlic: a review. Crit Rev Food Sci Nutr, 44, 479-88. https://doi.org/10.1080/10408690490886700
  7. Kim DJ, Shin DH, Ahn B, et al (2003). Chemoprevention of colon cancer by Korean food plant components. Mutat Res, 523-524, 99-107. https://doi.org/10.1016/S0027-5107(02)00325-1
  8. Kinzler KW, Vogelstein B (1996). Lessons from hereditary colorectal cancer. Cell, 87, 159-170. https://doi.org/10.1016/S0092-8674(00)81333-1
  9. Lai KC, Hsu SC, Kuo CL, et al (2011). Diallyl sulfide, diallyl disulfide, and diallyl trisulfide inhibit migration and invasion in human colon cancer colo 205 cells through the inhibition of matrix metalloproteinase-2, -7, and -9 expressions. Environ Toxicol (in ress).
  10. Leach FS, Elledge SJ, Sherr CJ, et al (1993). Amplification of cyclin genes in colorectal carcinomas. Cancer Res, 53, 1986-9.
  11. Moriarty RM, Naithani R, Surve B (2007). Organosulfur compounds in cancer chemoprevention. Mini Rev Med Chem, 7, 827-38. https://doi.org/10.2174/138955707781387939
  12. Moser AR, Pitot HC, Dove WF (1990). A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science, 247, 322-4. https://doi.org/10.1126/science.2296722
  13. Paulsen JE, Steffensen IL, Loberg EM, et al (2001). Qualitative and quantitative relationship between dysplastic aberrant crypt foci and tumorigenesis in the Min/+ mouse colon. Cancer Res, 61, 5010-5.
  14. Shoemaker AR, Moser AR, Dove WF (1995). N-ethyl-Nnitrosourea treatment of multiple intestinal neoplasia (Min) mice: age-related effects on the formation of intestinal adenomas, cystic crypts, and epidermoid cysts. Cancer Res, 55, 4479-85.
  15. Shukla Y, Kalra N (2007). Cancer chemoprevention with garlic and its constituents. Cancer Lett, 247, 167-81. https://doi.org/10.1016/j.canlet.2006.05.009
  16. Sriram N, Kalayarasan S, Ashokkumar P, et al (2008). Diallyl sulfide induces apoptosis in Colo 320 DM human colon cancer cells: involvement of caspase-3, NF-kappaB, and ERK-2. Mol Cell Biochem, 311, 157-65. https://doi.org/10.1007/s11010-008-9706-8
  17. Su LK, Kinzler KW, Vogelstein B, et al (1992). Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science, 256, 668-70. https://doi.org/10.1126/science.1350108
  18. Takahashi M, Fukuda K, Sugimura T, et al (1998). Betacatenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors. Cancer Res, 58, 42-6.
  19. Tetsu O, McCormick F (1999). Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature, 398, 422-6. https://doi.org/10.1038/18884
  20. Wang QS, Papanikolaou A, Sabourin CL, et al (1998). Altered expression of cyclin D1 and cyclin-dependent kinase 4 in azoxymethane-induced mouse colon tumorigenesis. Carcinogenesis, 19, 2001-6. https://doi.org/10.1093/carcin/19.11.2001
  21. Wargovich MJ, Chen CD, Jimenez A, et al (1996). Aberrant crypts as a biomarker for colon cancer: evaluation of potential chemopreventive agents in the rat. Cancer Epidemiol Biomarkers Prev, 5, 355-60.
  22. Zhang T, Nanney LB, Luongo C, et al (1997). Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients. Cancer Res, 57, 169-75.

Cited by

  1. Inhibitory Effects of Low-Dose Aloe-Emodin on the Development of Colorectal Tumors in Min Mice vol.15, pp.14, 2014, https://doi.org/10.7314/APJCP.2014.15.14.5587
  2. Chronic diseases, inflammation, and spices: how are they linked? vol.16, pp.1, 2018, https://doi.org/10.1186/s12967-018-1381-2