대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

재발성 아프타성 구내염 환자에 대한 가미육미지황탕의 효능

Efficacy of Gamiyukmijihwang-tang on Recurrent Aphthous Stomatitis

  • 김주연 (경희대학교 한의과대학 비계내과학교실) ;
  • 김진성 (경희대학교 한의과대학 비계내과학교실) ;
  • 손지희 (경희대학교 한의과대학 비계내과학교실) ;
  • 선종기 (경희대학교 한의과대학 비계내과학교실) ;
  • 강경 (경희대학교 한의과대학 비계내과학교실) ;
  • 장승원 (경희대학교 한의과대학 비계내과학교실) ;
  • 손지영 (경희대학교 한의과대학 비계내과학교실) ;
  • 류봉하 (경희대학교 한의과대학 비계내과학교실)
  • Kim, Ju-Yeon (Dept. of Gastroenterology, College of Oriental Medicine, Kyung-Hee University) ;
  • Kim, Jin-Sung (Dept. of Gastroenterology, College of Oriental Medicine, Kyung-Hee University) ;
  • Son, Ji-Hee (Dept. of Gastroenterology, College of Oriental Medicine, Kyung-Hee University) ;
  • Seon, Jong-Ki (Dept. of Gastroenterology, College of Oriental Medicine, Kyung-Hee University) ;
  • Kang, Kyung (Dept. of Gastroenterology, College of Oriental Medicine, Kyung-Hee University) ;
  • Jang, Seung-Won (Dept. of Gastroenterology, College of Oriental Medicine, Kyung-Hee University) ;
  • Son, Ji-Young (Dept. of Gastroenterology, College of Oriental Medicine, Kyung-Hee University) ;
  • Ryu, Bong-Ha (Dept. of Gastroenterology, College of Oriental Medicine, Kyung-Hee University)
  • 발행 : 2012.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives : This study was designed to investigate the Efficacy of Gamiyukmijihwang-tang on Recurrent Aphthous Stomatitis. Methods : We surveyed 10 recurrent aphthous stomatitis patients visited the oral diseases clinic in the Kyung Hee University Oriental Medicine Hospital from September, 2011 to March, 2012. Before and 2 weeks after taking Gamiyukmijihwang-tang, the subjects were evaluated on clinical characteristics of recurrent aphthous stomatitis, severity of pain using visual analogue scale (VAS), quality of life about oral health (based on the 14-item Oral Health Impact Profile-14) and yin-deficiency condition (based on the 10-item Yin-deficiency Questionnaire). Then, 5 patients who had already finished treatment were assessed about recurrence of recurrent aphthous stomatitis by telephone survey 6 weeks later. Results : After 2 weeks taking Gamiyukmijihwang-tang, clinical characteristics of 10 patients of recurrent aphthous stomatitis improved; their severity of pain, quality of life about oral health and yin-deficiency condition improved significantly. After 6 weeks, 3 of 5 patients who had already finished treatment didn't experience recurrence of recurrent aphthous stomatitis. The other 2 patients experienced a recurrence, but their clinical characteristics of recurrent aphthous stomatitis improved significantly. Conclusions : Gamiyukmijihwang-tang is effective on recurrent aphthous stomatitis. Studies with a larger number of cases and longer follow-up will be needed in the future.

키워드

참고문헌

  1. Jurge S, Kuffer R, Scully C, Porter SR. Mucosal disease series. Number VI. Recurrent aphthous stomatitis. Oral Dis 2006;12:1-21.
  2. Femiano F, Lanza A, Buonaiuto C, Gombos F, Nunziata M, Piccolo S, et al. Guidelines for diagnosis and management of aphthous stomatitis. Pediatr Infect Dis J. 2007;26(8):728-32. https://doi.org/10.1097/INF.0b013e31806215f9
  3. Pizarro A, Navarro A, Fonseca E, Vidaurrazaga C, Herranz P. Treatment of recuurent aphthous stomatitis with pentoxfylline. Br J Dermatol 1995;133:659-60. https://doi.org/10.1111/j.1365-2133.1995.tb02728.x
  4. 이형철, 이상욱, 배은주, 박성욱, 윤성우, 고창남. 중풍환자에서 금연 후 발생한 재발성 아프타성 구내염에 대한 증례보고. 대한한방내과학회지 2003;24(4):967-74.
  5. 김혜정. 구내염에 대한 임상적 고찰. 동의학회지 1999;3(1):100-5.
  6. 이명선, 김설희, 양정승, 오정숙, 김동기. 65세 이상 일부 노인의 Oral Health Impact Profile의 타당도 및 신뢰도. 대한구강보건학회지 2005;29(2) :210-21.
  7. Lee S. Park J. Lee H. Kim K. Development and validation of Yin-Deficiency Questionnaire. Am J Chin Med 2007;35(1):11-20. https://doi.org/10.1142/S0192415X07004576
  8. Vincent SD, Lily GE. Clinical, historic and therapeutic features of aphthous stomatitis. Literature review and open clinical trial employing steroids. Oral Surg Oral Med Oral Pathol 1992;74:79-86. https://doi.org/10.1016/0030-4220(92)90219-G
  9. 전국한의과대학 비계내과학교실. 비계내과학. 서울: 군자출판사; 2009, p. 310.
  10. Pedersen A, Hornsleth A. Recurrent aphthous ulceration: a possible clinical manifestation of reactivation of varicella zoster or cytomegalovirus infection. J Oral Pathol Med 1993;22:64-8. https://doi.org/10.1111/j.1600-0714.1993.tb00045.x
  11. Scully C, Porter SR. Recurrent aphthous stomatitis: current concepts of etiology, pathogenesis and management. J Oral Pathol Med 1989;18:21-7. https://doi.org/10.1111/j.1600-0714.1989.tb00727.x
  12. Porter SR, Scully C. Aphthous stomatitisan overveiw of aetiopathogenesis and management. Clin Exp Dermatol 1991;16:235-43. https://doi.org/10.1111/j.1365-2230.1991.tb00365.x
  13. Hunter L, Addy M. Chlorhexidine gluconate mouthwash in the management of minor aphthous stomatitis. Br Dent 1987;162:106-10. https://doi.org/10.1038/sj.bdj.4806042
  14. Mattews RW, Scully CM, Levers BGH, Hislop WS. Clinical evaluation of benzydamine, chlorhexidine and placebo mouthwashes in the management of recurrent aphthuos stomatitis. Oral Surg 1987;63:189-91. https://doi.org/10.1016/0030-4220(87)90310-0
  15. Scully C, Porter SR. Recurrent aphthous stomatitis: current concepts of etiology, pathogenesis and management. J Oral Pathol Med 1989;18:21-7. https://doi.org/10.1111/j.1600-0714.1989.tb00727.x
  16. 楊維傑. 黃帝內經 素問譯解. 臺北: 台聯國風出版社; 中華 65年, p. 51, 538, 562.
  17. 巢原方. 巢氏諸病原候論. 서울: 大成文化社; 1992, p. 216.
  18. 朱震亨. 丹溪治法心要. 山東: 山東科學技術出版社; 1985, p. 161.
  19. 龔廷賢. 萬病回春, 北京: 世一書局; 1985, p. 15-6.
  20. 許浚. 東醫寶鑑. 서울: 南山堂; 1994, p. 241-54.
  21. 李梴. 醫學入門(下). 서울: 南山堂; 1988, p. 1442-4.
  22. 張景岳. 景岳全書(上). 서울: 大成文化社; 1988, p. 549.
  23. 유진곤, 최관호, 김용국, 강성구, 정순영, 정재호, 등. 구창의 외용약으로 다용되는 황백, 청대, 백반 및 오배자의 항염작용에 관한 연구. 한방안이비인후피부과학회지 2005;18(1):183-98.
  24. 이준경, 이남헌, 하혜경, 이호영, 정다영, 최지윤, 등. EBM 구축을 위한 육미지황탕 문헌 분석 연구. 동의생리병리학회지 2009;23(1):15-26.
  25. Zheng LW, Hua H, Cheung LK. Traditional Chinese medicine and oral diseases: today and tomorrow. Oral Dis 2011;17(1):7-12. https://doi.org/10.1111/j.1601-0825.2010.01706.x
  26. 한선우, 홍삼표, 김진명, 최남식, 홍은기, 오현주. 한국 치과인의 재발성 아프타 구내염의 유병율과 임상소견에 관한 연구. 대한치과의사협회지 2001;39(1):62-70.