Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Acute Toxicity Study on the Extract of Mori Fructus

상심자의 급성독성에 관한 연구

  • Chang, Bo-Yoon (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Kim, Seon-Beom (College of Pharmacy, Chungbuk National University) ;
  • Lee, Mi-Kyeong (College of Pharmacy, Chungbuk National University) ;
  • Kim, Sung-Yeon (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University)
  • Received : 2012.02.17
  • Accepted : 2012.05.02
  • Published : 2012.06.30
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Abstract

Acute toxicity on the water extract of Mori Fructus was examined in male and female mice. The water extract of Mori Fructus was orally administered at a dose of 5 mg/kg, 50 mg/kg, 300 mg/kg and 2,000 mg/kg and had been observed for two weeks. No mortality and abnormal clinical signs were shown for the observation period. At the terminal sacrifice, there were no difference in net body weight gain, organ weight and gross pathological findings among the groups treated with different doses of the water extract of Mori Fructus. The results suggested that under the condition employed in this study $LD_{50}$ would be more than 2,000 mg/kg. All the data obtained the experiments lead to the water extract of Mori Fructus should have very low acute toxicity.

Keywords

References

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