생약학회지 (Korean Journal of Pharmacognosy)

  • 제43권2호
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  • Pages.101-106
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  • 2012
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  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

Poloxamer-407로 유도한 고지혈증 동물모델에서 Quercetin-3-O-rhamnoside 및 어성초 분획물의 항고지혈증 효과

Anti-hyperlipidemic Effect of the Isolated Component, Quercetin-3-O-rhamnoside and the Fractions from the Extract of Houttuynia Cordata in Mice

  • 김도국 (원광대학교 약학대학 한약학과 및 원광한약연구소) ;
  • 김세건 (원광대학교 약학대학 한약학과 및 원광한약연구소) ;
  • 암릿파우델 (원광대학교 약학대학 한약학과 및 원광한약연구소) ;
  • 정태숙 (한국생명공학연구소 바이오시스템연구본부 산업바이오소재연구센터) ;
  • 정현주 (원광대학교 약학대학 한약학과 및 원광한약연구소)
  • Kim, Do-Kuk (Department of Oriental Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University) ;
  • Kim, Se-Gun (Department of Oriental Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University) ;
  • Poudel, Amrit (Department of Oriental Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University) ;
  • Jeong, Tae-Suk (Korea Research Institute of Bioscience & Biotechnology, Biosystem Research, Industrial Bio-materials Research Center) ;
  • Jung, Hyun-Ju (Department of Oriental Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University)
  • 투고 : 2012.05.02
  • 심사 : 2012.06.04
  • 발행 : 2012.06.30
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초록

The anti-hyperlipidemic effect of Houttuynia cordata was assessed in poloxamer-407 induced hyperlipidemic mice model. The butanol fraction and its isolated compound, quercetin-3-O-rhamnoside, significantly reduced the blood triglyceride and total-cholesterol level and increased the blood HDL-cholesterol level. They also showed the significant reductive effect on the blood AST and ALT level, rising in proportion to the liver damage, in hyperlipidemic mice.

키워드

참고문헌

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