Journal of the Korean Academy of Child and Adolescent Psychiatry

대한소아청소년정신의학회 (Korean Academy of Child and Adolescent Psychiatry)
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주의력결핍 과잉행동장애와 뚜렛증후군 아동의 모발 중금속 분석

Analysis of Heavy Metals in the Hair of Children with Attention-Deficit Hyperactivity Disorder and Tourette's Syndrome

  • 조성연 (인하대학교 의과대학 정신건강의학교실) ;
  • 옥선명 (가톨릭대학교 의과대학 가정의학교실) ;
  • 이명훈 (인하대학교 의과대학 정신건강의학교실) ;
  • 강민희 (인하대학교 의과대학 정신건강의학교실) ;
  • 김철응 (인하대학교 의과대학 정신건강의학교실) ;
  • 배재남 (인하대학교 의과대학 정신건강의학교실) ;
  • 이정섭 (인하대학교 의과대학 정신건강의학교실)
  • Cho, Sung-Yun (Department of Psychiatry, Inha University College of Medicine) ;
  • Ock, Sun-Myeong (Department of Family Medicine, The Catholic University of Korea College of Medicine) ;
  • Lee, Myung-Hoon (Department of Psychiatry, Inha University College of Medicine) ;
  • Kang, Min-Hee (Department of Psychiatry, Inha University College of Medicine) ;
  • Kim, Chul-Eung (Department of Psychiatry, Inha University College of Medicine) ;
  • Bae, Jae-Nam (Department of Psychiatry, Inha University College of Medicine) ;
  • Lee, Jeong-Seop (Department of Psychiatry, Inha University College of Medicine)
  • 투고 : 2012.03.09
  • 심사 : 2012.05.09
  • 발행 : 2012.06.30
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초록

Objectives : The purpose of this study was to examine the association of exposures to heavy metals with positive diagnosis for attention-deficit hyperactivity disorder (ADHD) and Tourette's syndrome (TS). Methods : Study participants included 27 children diagnosed with ADHD ($9.9{\pm}2.9$ years of age), 21 diagnosed with Tourette's disorder ($10.7{\pm}2.2$ years of age), and 45 normal control children ($9.6{\pm}0.5$ years of age). A Perkin-Elmer mass spectrometer was used to measure the concentrations of 5 heavy metals (Pb, Cd, U, Be, Hg) in hair samples obtained from each participant. Each heavy metal concentration was compared among the groups by use of a Kruskal-Wallis test. Results : The levels of lead (p=.006) and cadmium (p=.037) observed in the hair of children diagnosed with ADHD were significantly higher than those found in the control subjects. There were no significant differences observed for heavy metal levels when comparing TS and control subjects. Conclusion : We confirmed that lead exposure is a risk factor for ADHD. We also identified that cadmium may be a new candidate risk factor for manifestation of ADHD. We did not find an association between heavy metals and manifestation of TS.

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참고문헌

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피인용 문헌

  1. Assessment of Essential Minerals in Human Hair by Age Groups and Sexes in the Southern Province of Gyeonggi-do, Korea vol.14, pp.1, 2012, https://doi.org/10.15810/jic.2018.14.1.006