Journal of the Korean Academy of Child and Adolescent Psychiatry

대한소아청소년정신의학회 (Korean Academy of Child and Adolescent Psychiatry)
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약물 복용력이 없는 주의력결핍 과잉행동장애 아동에서의 뒤쪽 내정상태회로 이상 : 휴식상태 기능적 뇌자기공명영상 연구

The Abnormality of Posterior Default Mode Network in Medication-Naïve Attention-Deficit Hyperactivity Disorder Children : Resting State fMRI Study

  • 최지욱 (가톨릭대학교 의과대학 대전성모병원 정신건강의학교실) ;
  • 고효진 (가톨릭대학교 의과대학 대전성모병원 정신건강의학교실) ;
  • 우영섭 (가톨릭대학교 의과대학 대전성모병원 정신건강의학교실) ;
  • 송승훈 (가톨릭대학교 의과대학 대전성모병원 정신건강의학교실) ;
  • 양보성 (가톨릭대학교 의과대학 대전성모병원 영상의학교실) ;
  • 정범석 (한국과학기술원 의과학대학원)
  • Choi, Jee-Wook (Departments of Psychiatry, College of Medicine, The Catholic University of Korea, Daejeon St. Mary's Hospital) ;
  • Go, Hyo-Jin (Departments of Psychiatry, College of Medicine, The Catholic University of Korea, Daejeon St. Mary's Hospital) ;
  • Woo, Young-Sup (Departments of Psychiatry, College of Medicine, The Catholic University of Korea, Daejeon St. Mary's Hospital) ;
  • Song, Seung-Hoon (Departments of Psychiatry, College of Medicine, The Catholic University of Korea, Daejeon St. Mary's Hospital) ;
  • Yang, Po-Song (Department of Radiology, College of Medicine, The Catholic University of Korea, Daejeon St. Mary's Hospital) ;
  • Jeong, Bum-Seok (Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology)
  • 투고 : 2012.02.28
  • 심사 : 2012.04.25
  • 발행 : 2012.06.30
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초록

Objectives : Characteristic symptoms, including hyperactivity and easy distractibility, in children with attention-deficit hyperactivity disorder (ADHD) suggest that their brain status, even at rest, might differ from that of healthy children. This study was conducted in order to determine whether resting state brain activity is compromised in medication-naive children with ADHD. Methods : Twenty medication-naive children with ADHD (mean age $10.3{\pm}2.5$) and 28 age- and gender-matched healthy volunteers (mean age $10.3{\pm}2.0$) underwent measurements for resting state brain activity using functional magnetic resonance imaging (fMRI). Among resting state related-independent components (RSICs) extracted from fMRI data using independent component analysis, a significant difference in RSICs was observed between groups, using a mixed Gaussian/gamma model. Results : Except for IQ, which was higher in the healthy control group, no demographic difference was observed between the two groups (p<.001). Significantly less activation of one RSIC, which includes the bilateral precuneus/posterior cingulate cortex, occipito-temporal junction, and anterior cingulate cortex, was observed in the ADHD group, compared with the control group (p<.05). Conclusion : An abnormal RSIC, posterior default mode network (DMN), was observed in the medication-naive ADHD group. Results of our study suggest that abnormality of posterior DMN is one of the main pathophysiologies of ADHD.

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참고문헌

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