Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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A Facile Synthesis of Discoidal Lipid Bilayer Nanostructure by Association of a Cationic Amphiphilic Polyelectrolyte

  • Cho, Eun-Chul (Department of Chemical Engineering, Division of Chemical and Bioengineering, Hanyang University)
  • Received : 2012.03.05
  • Accepted : 2012.03.28
  • Published : 2012.07.20
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Abstract

This study presents a facile way synthesizing disc-like lipid bilyaer nanostructures with a cationic amphiphilic polyelectrolyte. The cationic amphiphilic polyelectrolyte was in a form of partially quarternized copolymer and was synthesized with 2-(dimethylamino)ethyl methacrylate and stearyl methacrylate. At some concentration ranges of the polymer, the addition of the polymer to lipid components during the preparation of bilayer nanostructures resulted in discs with a fairly high yield (~99%). The mechanism for the formation of the nanostructures was discussed based on the physical properties of these nanostructures and by comparing the nanostructures obtained with an anionic amphiphilic polyelectrolyte.

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